Search Results - "Rustenbeck, Ingo"

Short-Term Inhibition of Translation by Cycloheximide Concurrently Affects Mitochondrial Function and Insulin Secretion in Islets from Female Mice by Alshafei, Mohammed, Schulze, Torben, Morsi, Mai, Panten, Uwe, Rustenbeck, Ingo

“…Since glucose stimulates protein biosynthesis in beta cells concomitantly with the stimulation of insulin release, the possible interaction of both processes…”
Get full text

The Dynamics of Calcium Signaling in Beta Cells-A Discussion on the Comparison of Experimental and Modelling Data by Müller, Michael, Walkling, Jonas, Seemann, Nele, Rustenbeck, Ingo

“…The stimulus-secretion coupling of the pancreatic beta cell is particularly complex, as it integrates the availability of glucose and other nutrients with the…”
Get full text

Nonmechanical parfocal and autofocus features based on wave propagation distribution in lensfree holographic microscopy by Dharmawan, Agus Budi, Mariana, Shinta, Scholz, Gregor, Hörmann, Philipp, Schulze, Torben, Triyana, Kuwat, Garcés-Schröder, Mayra, Rustenbeck, Ingo, Hiller, Karsten, Wasisto, Hutomo Suryo, Waag, Andreas

“…Performing long-term cell observations is a non-trivial task for conventional optical microscopy, since it is usually not compatible with environments of an…”
Get full text

The Proton Leak of the Inner Mitochondrial Membrane Is Enlarged in Freshly Isolated Pancreatic Islets by Alshafei, Mohammed, Morsi, Mai, Reschke, Julia, Rustenbeck, Ingo

“…In a number of investigations on the mechanism of the metabolic amplification of insulin secretion, differences between the response of freshly isolated islets…”
Get full text

What Is the Metabolic Amplification of Insulin Secretion and Is It (Still) Relevant? by Rustenbeck, Ingo, Schulze, Torben, Morsi, Mai, Alshafei, Mohammed, Panten, Uwe

“…The pancreatic beta-cell transduces the availability of nutrients into the secretion of insulin. While this process is extensively modified by hormones and…”
Get full text

Differences in lipid metabolism in acquired versus preexisting glucose intolerance during gestation: role of free fatty acids and sphingosine-1-phosphate by Liebmann, Moritz, Grupe, Katharina, Asuaje Pfeifer, Melissa, Rustenbeck, Ingo, Scherneck, Stephan

“…Abstract Background The prevalence of gestational diabetes mellitus (GDM) is increasing worldwide. There is increasing evidence that GDM is a heterogeneous…”
Get full text

Pharmacological inhibition of thioredoxin reductase increases insulin secretion and diminishes beta cell viability by Brüning, Dennis, Hatlapatka, Kathrin, Lier-Glaubitz, Verena, Andermark, Vincent, Scherneck, Stephan, Ott, Ingo, Rustenbeck, Ingo

“…Apparently, both a decrease in beta cell function and in beta cell mass contribute to the progressive worsening of type 2 diabetes. So, it is of particular…”
Get full text

The changing view of insulin granule mobility: From conveyor belt to signaling hub by Gaus, Bastian, Brüning, Dennis, Groß, Sofie, Müller, Michael, Rustenbeck, Ingo

“…Before the advent of TIRF microscopy the fate of the insulin granule prior to secretion was deduced from biochemical investigations, electron microscopy and…”
Get full text

PyCreas: a tool for quantification of localization and distribution of endocrine cell types in the islets of Langerhans by Asuaje Pfeifer, Melissa, Langehein, Hans, Grupe, Katharina, Müller, Steffi, Seyda, Joana, Liebmann, Moritz, Rustenbeck, Ingo, Scherneck, Stephan

“…Manifest diabetes, but also conditions of increased insulin resistance such as pregnancy or obesity can lead to islet architecture remodeling. The contributing…”
Get full text

Fresh and cultured mouse islets differ in their response to nutrient stimulation by Morsi, Mai, Schulze, Torben, Früh, Eike, Brüning, Dennis, Panten, Uwe, Rustenbeck, Ingo

“…Observing different kinetics of nutrient-induced insulin secretion in fresh and cultured islets under the same condition we compared parameters of stimulus…”
Get full text

A Parallel Perifusion Slide From Glass for the Functional and Morphological Analysis of Pancreatic Islets by Schulze, Torben, Mattern, Kai, Erfle, Per, Brüning, Dennis, Scherneck, Stephan, Dietzel, Andreas, Rustenbeck, Ingo

“…An islet-on-chip system in the form of a completely transparent microscope slide optically accessible from both sides was developed. It is made from…”
Get full text

A Cellular Automaton Model as a First Model-Based Assessment of Interacting Mechanisms for Insulin Granule Transport in Beta Cells by Müller, Michael, Glombek, Mathias, Powitz, Jeldrick, Brüning, Dennis, Rustenbeck, Ingo

“…In this paper a first model is derived and applied which describes the transport of insulin granules through the cell interior and at the membrane of a beta…”
Get full text

Metabolic changes during pregnancy in glucose‐intolerant NZO mice: A polygenic model with prediabetic metabolism by Grupe, Katharina, Asuaje Pfeifer, Melissa, Dannehl, Franziska, Liebmann, Moritz, Rustenbeck, Ingo, Schürmann, Annette, Scherneck, Stephan

“…Gestational diabetes mellitus (GDM) is a complex metabolic disease involving genetic and environmental factors. Recent studies have underlined its…”
Get full text

An Immersible Microgripper for Pancreatic Islet and Organoid Research by Früh, Eike, Bütefisch, Sebastian, Gursky, Benjamin, Brüning, Dennis, Leester-Schädel, Monika, Dietzel, Andreas, Rustenbeck, Ingo

“…To improve the predictive value of in vitro experimentation, the use of 3D cell culture models, or organoids, is becoming increasingly popular. However, the…”
Get full text

Bidirectional Insulin Granule Turnover in the Submembrane Space During K+ Depolarization‐Induced Secretion by Hatlapatka, Kathrin, Matz, Magnus, Schumacher, Kirstin, Baumann, Knut, Rustenbeck, Ingo

“…Like primary mouse islets, MIN6 pseudoislets responded to the depolarization by 40 mm KCl and the resulting increase in the free cytosolic Ca2+ concentration…”
Get full text

The insulinotropic effect of fluoroquinolones by Ghaly, Hany, Kriete, Christine, Sahin, Seher, Pflöger, Anja, Holzgrabe, Ulrike, Zünkler, Bernd Joachim, Rustenbeck, Ingo

“…Antimicrobial fluoroquinolones induce, with strongly varying frequency, life-threatening hypoglycemias, which is explained by their ability to block K ATP…”
Get full text

A Toolbox for Translational Research on Beta Cell Function: Commentary on: "A Dual Reporter EndoC-[beta]H1 Human Beta Cell Line for Efficient Quantification of Calcium Flux and Insulin Secretion." by Schulze, Torben, Rustenbeck, Ingo

Get full text

A Toolbox for Translational Research on Beta Cell Function: Commentary on: “A Dual Reporter EndoC-βH1 Human Beta Cell Line for Efficient Quantification of Calcium Flux and Insulin Secretion.” by Schulze, Torben, Rustenbeck, Ingo

Get full text

A Toolbox for Translational Research on Beta Cell Function by Schulze, Torben, Rustenbeck, Ingo

Get full text

Selective enhancement of nutrient-induced insulin secretion by ATP-sensitive K+ channel-blocking imidazolines by Hatlapatka, Kathrin, Wienbergen, Antje, Kühne, Claudia, Jörns, Anne, Willenborg, Michael, Rustenbeck, Ingo

“…The contribution of ATP-sensitive K(+) channel (K(ATP) channel)-dependent and -independent signaling to the insulinotropic characteristics of imidazolines was…”
Get more information