Search Results - "Rust, G"

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma by Karreth, Florian A., Tay, Yvonne, Perna, Daniele, Ala, Ugo, Tan, Shen Mynn, Rust, Alistair G., DeNicola, Gina, Webster, Kaitlyn A., Weiss, Dror, Perez-Mancera, Pedro A., Krauthammer, Michael, Halaban, Ruth, Provero, Paolo, Adams, David J., Tuveson, David A., Pandolfi, Pier Paolo

“…We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs to regulate mRNA transcripts containing common microRNA recognition elements…”
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The mutational landscapes of genetic and chemical models of Kras-driven lung cancer by Westcott, Peter M. K., Halliwill, Kyle D., To, Minh D., Rashid, Mamunur, Rust, Alistair G., Keane, Thomas M., Delrosario, Reyno, Jen, Kuang-Yu, Gurley, Kay E., Kemp, Christopher J., Fredlund, Erik, Quigley, David A., Adams, David J., Balmain, Allan

“…Whole-exome sequencing is used to compare the mutational landscape of adenomas from three mouse models of non-small-cell lung cancer, induced either by…”
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Chromatin landscapes of retroviral and transposon integration profiles by de Jong, Johann, Akhtar, Waseem, Badhai, Jitendra, Rust, Alistair G, Rad, Roland, Hilkens, John, Berns, Anton, van Lohuizen, Maarten, Wessels, Lodewyk F A, de Ridder, Jeroen

“…The ability of retroviruses and transposons to insert their genetic material into host DNA makes them widely used tools in molecular biology, cancer research…”
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Capture Hi-C identifies putative target genes at 33 breast cancer risk loci by Baxter, Joseph S., Leavy, Olivia C., Dryden, Nicola H., Maguire, Sarah, Johnson, Nichola, Fedele, Vita, Simigdala, Nikiana, Martin, Lesley-Ann, Andrews, Simon, Wingett, Steven W., Assiotis, Ioannis, Fenwick, Kerry, Chauhan, Ritika, Rust, Alistair G., Orr, Nick, Dudbridge, Frank, Haider, Syed, Fletcher, Olivia

“…Genome-wide association studies (GWAS) have identified approximately 100 breast cancer risk loci. Translating these findings into a greater understanding of…”
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BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model by Perna, Daniele, Karreth, Florian A., Rust, Alistair G., Perez-Mancera, Pedro A., Rashid, Mamunur, Iorio, Francesco, Alifrangis, Constantine, Arends, Mark J., Bosenberg, Marcus W., Bollag, Gideon, Tuveson, David A., Adams, David J.

“…BRAF (v-raf murine sarcoma viral oncogene homolog B) inhibitors elicit a transient anti-tumor response in ∼80% of BRAF ⱽ⁶⁰⁰-mutant melanoma patients that…”
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Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma by Mann, Karen M., Ward, Jerrold M., Yew, Christopher Chin Kuan, Kovochich, Anne, Dawson, David W., Black, Michael A., Brett, Benjamin T., Sheetz, Todd E., Dupuy, Adam J., Chang, David K., Biankin, Andrew V., Waddell, Nicola, Kassahn, Karin S., Grimmond, Sean M., Rust, Alistair G., Adams, David J., Jenkins, Nancy A., Copeland, Neal G.

“…Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late…”
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Prevalence, treatment, and control of depressive symptoms in the United States: results from the National Health and Nutrition Examination Survey (NHANES), 2005-2008 by Shim, Ruth S, Baltrus, Peter, Ye, Jiali, Rust, George

“…depression remains a major public health problem that is most often evaluated and treated in primary care settings. The objective of this study was to examine…”
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Inactivating CUX1 mutations promote tumorigenesis by Wong, Chi C, Martincorena, Inigo, Rust, Alistair G, Rashid, Mamunur, Alifrangis, Constantine, Alexandrov, Ludmil B, Tiffen, Jessamy C, Kober, Christina, Green, Anthony R, Massie, Charles E, Nangalia, Jyoti, Lempidaki, Stella, Döhner, Hartmut, Döhner, Konstanze, Bray, Sarah J, McDermott, Ultan, Papaemmanuil, Elli, Campbell, Peter J, Adams, David J

“…David Adams and colleagues identify inactivating mutations in CUX1 in diverse human cancers. They validate CUX1 as a tumor suppressor using mouse and…”
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Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development by Takeda, Haruna, Rust, Alistair G., Ward, Jerrold M., Yew, Christopher Chin Kuan, Jenkins, Nancy A., Copeland, Neal G.

“…Mutations in SMAD4 predispose to the development of gastrointestinal cancer, which is the third leading cause of cancer-related deaths. To identify genes…”
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PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia by Dang, Jinjun, Wei, Lei, de Ridder, Jeroen, Su, Xiaoping, Rust, Alistair G., Roberts, Kathryn G., Payne-Turner, Debbie, Cheng, Jinjun, Ma, Jing, Qu, Chunxu, Wu, Gang, Song, Guangchun, Huether, Robert G., Schulman, Brenda, Janke, Laura, Zhang, Jinghui, Downing, James R., van der Weyden, Louise, Adams, David J., Mullighan, Charles G.

“…Alterations of genes encoding transcriptional regulators of lymphoid development are a hallmark of B-progenitor acute lymphoblastic leukemia (B-ALL) and most…”
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A Data Integration Methodology for Systems Biology by Daehee Hwang, Rust, Alistair G., Stephen Ramsey, Smith, Jennifer J., Deena M. Leslie, Weston, Andrea D., Pedro de Atauri, Aitchison, John D., Hood, Leroy, Siegel, Andrew F., Bolouri, Hamid

“…Different experimental technologies measure different aspects of a system and to differing depth and breadth. High-throughput assays have inherently high…”
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Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics by Ramsey, Stephen A, Klemm, Sandy L, Zak, Daniel E, Kennedy, Kathleen A, Thorsson, Vesteinn, Li, Bin, Gilchrist, Mark, Gold, Elizabeth S, Johnson, Carrie D, Litvak, Vladimir, Navarro, Garnet, Roach, Jared C, Rosenberger, Carrie M, Rust, Alistair G, Yudkovsky, Natalya, Aderem, Alan, Shmulevich, Ilya

“…Macrophages are versatile immune cells that can detect a variety of pathogen-associated molecular patterns through their Toll-like receptors (TLRs). In…”
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Adenoma development in familial adenomatous polyposis and MUTYH-associated polyposis: somatic landscape and driver genes by Rashid, Mamunur, Fischer, Andrej, Wilson, Cathy H, Tiffen, Jessamy, Rust, Alistair G, Stevens, Philip, Idziaszczyk, Shelley, Maynard, Julie, Williams, Geraint T, Mustonen, Ville, Sampson, Julian R, Adams, David J

“…Familial adenomatous polyposis (FAP) and MUTYH‐associated polyposis (MAP) are inherited disorders associated with multiple colorectal adenomas that lead to a…”
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Identification of FoxR2 as an Oncogene in Medulloblastoma by KOSO, Hideto, TSUHAKO, Asano, LYONS, Eli, WARD, Jerrold M, RUST, Alistair G, ADAMS, David J, JENKINS, Nancy A, COPELAND, Neal G, WATANABE, Sumiko

“…Medulloblastoma is the most common pediatric brain tumor, and in ∼25% of cases, it is driven by aberrant activation of the Sonic Hedgehog (SHH) pathway in…”
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Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups by Genovesi, Laura A, Ng, Ching Ging, Davis, Melissa J, Remke, Marc, Taylor, Michael D, Adams, David J, Rust, Alistair G, Ward, Jerrold M, Ban, Kenneth H, Jenkins, Nancy A, Copeland, Neal G, Wainwright, Brandon J

“…The Sleeping Beauty (SB) transposon mutagenesis screen is a powerful tool to facilitate the discovery of cancer genes that drive tumorigenesis in mouse models…”
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Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells by Koso, Hideto, Takeda, Haruna, Yew, Christopher Chin Kuan, Ward, Jerrold M, Nariai, Naoki, Ueno, Kazuko, Nagasaki, Masao, Watanabe, Sumiko, Rust, Alistair G, Adams, David J, Copeland, Neal G, Jenkins, Nancy A

“…Neural stem cells (NSCs) are considered to be the cell of origin of glioblastoma multiforme (GBM). However, the genetic alterations that transform NSCs into…”
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Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4 by Aderem, Alan, Gilchrist, Mark, Thorsson, Vesteinn, Li, Bin, Rust, Alistair G, Korb, Martin, Kennedy, Kathleen, Hai, Tsonwin, Bolouri, Hamid

“…The innate immune system is absolutely required for host defence, but, uncontrolled, it leads to inflammatory disease. This control is mediated, in part, by…”
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Modeling the evolution of ETV6-RUNX1–induced B-cell precursor acute lymphoblastic leukemia in mice by van der Weyden, Louise, Giotopoulos, George, Rust, Alistair G., Matheson, Louise S., van Delft, Frederik W., Kong, Jun, Corcoran, Anne E., Greaves, Mel F., Mullighan, Charles G., Huntly, Brian J., Adams, David J.

“…The t(12;21) translocation that generates the ETV6-RUNX1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is…”
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A Genomic Regulatory Network for Development by Davidson, Eric H., Rast, Jonathan P., Oliveri, Paola, Ransick, Andrew, Calestani, Cristina, Yuh, Chiou-Hwa, Minokawa, Takuya, Amore, Gabriele, Hinman, Veronica, Arenas-Mena, César, Otim, Ochan, Brown, C. Titus, Livi, Carolina B., Lee, Pei Yun, Revilla, Roger, Rust, Alistair G., Pan, Zheng jun, Schilstra, Maria J., Peter J. C. Clarke, Arnone, Maria I., Rowen, Lee, Cameron, R. Andrew, McClay, David R., Hood, Leroy, Bolouri, Hamid

“…Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and…”
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A Data Integration Methodology for Systems Biology: Experimental Verification by Daehee Hwang, Smith, Jennifer J., Deena M. Leslie, Weston, Andrea D., Rust, Alistair G., Stephen Ramsey, Pedro de Atauri, Siegel, Andrew F., Bolouri, Hamid, Aitchison, John D., Hood, Leroy

“…The integration of data from multiple global assays is essential to understanding dynamic spatiotemporal interactions within cells. In a companion paper, we…”
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