Search Results - "Russkamp, Norman F."

Extracellular histones are essential effectors of C5aR‐ and C5L2‐mediated tissue damage and inflammation in acute lung injury by Bosmann, Markus, Grailer, Jamison J., Ruemmler, Robert, Russkamp, Norman F., Zetoune, Firas S., Sarma, J. Vidya, Standiford, Theodore J., Ward, Peter A.

“…We investigated how complement activation promotes tissue injury and organ dysfunction during acute inflammation. Three models of acute lung injury (ALI)…”
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Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report by Koch, Christian, Fleischer, Juliane, Popov, Todor, Frontzek, Karl, Schreiner, Bettina, Roth, Patrick, Manz, Markus G., Unseld, Simone, Müller, Antonia M. S., Russkamp, Norman F.

“…BackgroundImmune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell…”
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Fingerprinting of the TLR4-induced acute inflammatory response by Bosmann, Markus, Russkamp, Norman F., Ward, Peter A.

“…Intensive scientific efforts in the past decades have helped shed light into the pathogenesis of endotoxin-induced inflammation. We have used multiplexing…”
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Intrasinusoidal bone marrow involvement in mantle cell lymphoma: a case series with review of the main differential diagnoses by Bonometti, Arturo, Tzankov, Alexander, Alborelli, Ilaria, Russkamp, Norman F, Dertinger, Susanne, Dirnhofer, Stefan

“…Intrasinusoidal bone marrow involvement is an infrequent histological pattern observed in a limited number of B and T cell lymphomas. Mantle cell lymphoma is a…”
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Anti-CD117 immunotherapy to eliminate hematopoietic and leukemia stem cells by Russkamp, Norman F., Myburgh, Renier, Kiefer, Jonathan D., Neri, Dario, Manz, Markus G.

“…•Immunologic conditioning with anti-CD117 antibodies has exhibited efficacy and safety in experimental models and clinical trials.•Immunologic conditioning…”
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Selective CD117+ HSC exchange therapy by Manz, Markus G., Russkamp, Norman F.

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CD11c+ Alveolar Macrophages are a Source of IL-23 During Lipopolysaccharide-Induced Acute Lung Injury by Bosmann, Markus, Grailer, Jamison J., Russkamp, Norman F., Ruemmler, Robert, Zetoune, Firas S., Sarma, J. Vidya, Ward, Peter A.

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Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells by Myburgh, Renier, Kiefer, Jonathan D., Russkamp, Norman F., Magnani, Chiara F., Nuñez, Nicolás, Simonis, Alexander, Pfister, Surema, Wilk, C. Matthias, McHugh, Donal, Friemel, Juliane, Müller, Antonia M., Becher, Burkhard, Münz, Christian, van den Broek, Maries, Neri, Dario, Manz, Markus G.

“…Acute myeloid leukemia (AML) initiating and sustaining cells maintain high cell-surface similarity with their cells-of-origin, i.e., hematopoietic stem and…”
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Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin by Russkamp, Norman F., Ruemmler, Robert, Roewe, Julian, Moore, Bethany B., Ward, Peter A., Bosmann, Markus

“…ABSTRACT Excessive activation of the complement system is detrimental in acute inflammatory disorders. In this study, we analyzed the role of…”
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Long-Term Follow-Up of Antibody Titers Against Measles, Mumps, and Rubella in Recipients of Allogenic Hematopoietic Cell Transplantation by Bögeholz, Jan, Russkamp, Norman F., Wilk, Christian M., Gourri, Elise, Haralambieva, Eugenia, Schanz, Urs, Mueller, Nicolas J., Manz, Markus G., Müller, Antonia M.S.

“…•Loss of protective antibody levels over time differed substantially between measles, mumps and rubella in patients following allogeneic hematopoietic cell…”
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Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3 by Bosmann, Markus, Russkamp, Norman F, Strobl, Birgit, Roewe, Julian, Balouzian, Liza, Pache, Florence, Radsak, Markus P, van Rooijen, Nico, Zetoune, Firas S, Sarma, J Vidya, Núñez, Gabriel, Müller, Mathias, Murray, Peter J, Ward, Peter A

“…Severe sepsis and septic shock are leading causes of morbidity and mortality worldwide. Infection-associated inflammation promotes the development and…”
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CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury by Bosmann, Markus, Grailer, Jamison J, Russkamp, Norman F, Ruemmler, Robert, Zetoune, Firas S, Sarma, J Vidya, Ward, Peter A

“…Acute lung injury (ALI) is a severe pulmonary disease causing high numbers of fatalities worldwide. Innate immune responses are an integral part of the…”
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MyD88‐dependent production of IL‐17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway by Bosmann, Markus, Patel, Vinay R., Russkamp, Norman F., Pache, Florence, Zetoune, Firas S., Sarma, J. Vidya, Ward, Peter A.

“…ABSTRACT The interleukin‐17 (IL‐17) family of cytokines plays important roles in innate immune defenses against bacterial and fungal pathogens. While much is…”
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Disruption of CSF-1R signaling inhibits growth of AML with inv(16) by Simonis, Alexander, Russkamp, Norman F., Mueller, Jan, Wilk, C. Matthias, Wildschut, Mattheus H.E., Myburgh, Renier, Wildner-Verhey van Wijk, Nicole, Mueller, Rouven, Balabanov, Stefan, Valk, Peter J.M., Theocharides, Alexandre P.A., Manz, Markus G.

“…•Human inv(16) AML cells express CSF-1R and are exposed to CSF-1 in vivo.•Inhibition of CSF-1R signaling reduces viability of inv(16) AML cells in vitro and in…”
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The outcome of polymicrobial sepsis is independent of T and B cells by Bosmann, Markus, Russkamp, Norman F, Patel, Vinay R, Zetoune, Firas S, Sarma, J Vidya, Ward, Peter A

“…The contribution of the adaptive and innate immune systems to the pathogenesis and outcome of sepsis remains a fundamental yet controversial question. Here, we…”
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Anti-CD117 CAR T Cells Incorporating a Safety Switch Eradicate Acute Myeloid Leukemia and Deplete Human Hematopoietic Stem Cells by Magnani, Chiara F, Myburgh, Renier, Russkamp, Norman F, Pascolo, Steve, Shizuru, Judith A, Neri, Dario, Manz, Markus G

“…Introduction Acute Myeloid Leukemia (AML) arises from the accumulation of mutations within the hematopoietic stem and progenitor cells (HSPC), leading to the…”
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A Bispecific Antibody Targeting CD117 and CD3 Enables T Cell Mediated Killing of CD117-Expressing Healthy and Malignant Hematopoietic Cells by Kiefer, Jonathan D, Myburgh, Renier, Russkamp, Norman F, Volta, Laura, Guggisberg, Adrian, Abdelmotaleb, Omar, Mock, Jacqueline, Neri, Dario, Manz, Markus G

“…Hematopoietic stem and progenitor cells (HSPCs) support life-long hematopoiesis. A single HSPC can also be at the origin of hematological malignancies, such as…”
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Anti-Human CD117 CAR T-Cells Efficiently Eliminate Hematopoietic Stem and CD117-Positive AML Cells by Myburgh, Renier, Kiefer, Jonathan, Russkamp, Norman F, Simonis, Alexander, Pfister, Surema, Wilk, C. Matthias, Magnani, Chiara, Mueller, Antonia MS, Becher, Burkhard, van den Broek, Maries, Neri, Dario, Manz, Markus G.

“…Introduction: Acute Myeloid Leukemia (AML) is a clonal disease of the hematopoietic system that originates from immature hematopoietic stem and progenitor…”
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A single‐chain variable fragment‐based bispecific T‐cell activating antibody against CD117 enables T‐cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells by Volta, Laura, Myburgh, Renier, Hofstetter, Mara, Koch, Christian, Kiefer, Jonathan D., Gobbi, Celeste, Manfredi, Francesco, Zimmermann, Kathrin, Kaufmann, Philipp, Fazio, Serena, Pellegrino, Christian, Russkamp, Norman F., Villars, Danielle, Matasci, Mattia, Maurer, Monique, Mueller, Jan, Schneiter, Florin, Büschl, Paul, Harrer, Niclas, Mock, Jacqueline, Balabanov, Stefan, Nombela‐Arrieta, César, Schroeder, Timm, Neri, Dario, Manz, Markus G.

“…Abstract Acute myeloid leukemia (AML) derives from hematopoietic stem and progenitor cells (HSPCs). To date, no AML‐exclusive, non‐HSPC‐expressed cell‐surface…”
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CD11c+ Alveolar Macrophages are a Source of IL-23 during LPS-induced Acute Lung Injury by Bosmann, Markus, Grailer, Jamison J., Russkamp, Norman F., Ruemmler, Robert, Zetoune, Firas S., Sarma, J. Vidya, Ward, Peter A.

“…Acute lung injury (ALI) is a severe pulmonary disease causing high numbers of fatalities worldwide. Innate immune responses are an integral part of the…”
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