Clinical use of a one-compartment model for determining netilmicin pharmacokinetic parameters and dosage recommendations

Clinical use of a one-compartment model for determining netilmicin pharmacokinetic parameters and dosage recommendations

To determine netilmicin pharmacokinetic parameters and to evaluate the use of a one-compartment pharmacokinetic model, 32 patients receiving netilmicin for suspected gram-negative sepsis were enrolled in our study protocol. Dose and dosage interval for each patient were determined by one-compartment...

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Bibliographic Details
Published in:Therapeutic drug monitoring Vol. 5; no. 3; p. 263
Main Authors: Rotschafer, J C, Crossley, K B, Zaske, D E, Russillo, N J, Strate, R G, Tofte, R W, Solem, L D
Format: Journal Article
Language:English
Published: United States 01-01-1983
Subjects:
Adolescent
Adult
Aged
Creatinine - blood
Double-Blind Method
Drug Administration Schedule
Female
Gentamicins - metabolism
Humans
Kinetics
Male
Middle Aged
Models, Biological
Netilmicin - administration & dosage
Netilmicin - adverse effects
Netilmicin - metabolism
Prospective Studies
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Summary:To determine netilmicin pharmacokinetic parameters and to evaluate the use of a one-compartment pharmacokinetic model, 32 patients receiving netilmicin for suspected gram-negative sepsis were enrolled in our study protocol. Dose and dosage interval for each patient were determined by one-compartment pharmacokinetic analysis of six postinfusion netilmicin serum samples (0.16, 0.33, 0.5, 1, 2, and 3 h) measured by radioimmunoassay. In patients with a normal serum creatinine, mean (+/- SD) half-life and distribution volume were 1.9 +/- 1.1 h and 0.2 +/- 0.8 L/kg, respectively. The average daily dose and mean days of therapy were 5.1 +/- 1.9 mg/kg/day for 7.3 +/- 2.8 days. Serum creatinine changes of greater than 0.5 mg% occurred in 2 of 28 (7%) patients. Substantial variability in half-life and distribution volume occurred in patients. Initial dosages of 5-7 mg/kg/day in divided dosages seem appropriate for adult patients with normal renal function. Monitoring of serum levels and adjustment of dose and dosage interval are necessary to maintain therapeutic antibiotic concentrations. As with other aminoglycosides, the one-compartment pharmacokinetic model proved to be an acceptable method for measuring netilmicin pharmacokinetic parameters and individualizing therapy.
ISSN:0163-4356
DOI:10.1097/00007691-198309000-00005