Search Results - "Russell, Ryan J"

Genetic and epigenetic fine mapping of causal autoimmune disease variants by Farh, Kyle Kai-How, Marson, Alexander, Zhu, Jiang, Kleinewietfeld, Markus, Housley, William J., Beik, Samantha, Shoresh, Noam, Whitton, Holly, Ryan, Russell J. H., Shishkin, Alexander A., Hatan, Meital, Carrasco-Alfonso, Marlene J., Mayer, Dita, Luckey, C. John, Patsopoulos, Nikolaos A., De Jager, Philip L., Kuchroo, Vijay K., Epstein, Charles B., Daly, Mark J., Hafler, David A., Bernstein, Bradley E.

“…Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here…”
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Origins of tumor-associated macrophages and neutrophils by Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita, Rauch, Philipp J, Chudnovskiy, Aleksey, Berger, Cedric, Ryan, Russell J. H, Iwamoto, Yoshiko, Marinelli, Brett, Gorbatov, Rostic, Forghani, Reza, Novobrantseva, Tatiana I, Koteliansky, Victor, Figueiredo, Jose-Luiz, Chen, John W, Anderson, Daniel G, Nahrendorf, Matthias, Swirski, Filip K, Weissleder, Ralph, Pittet, Mikael J

“…Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) can control cancer growth and exist in almost all solid neoplasms. The cells are…”
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Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain by Shukla, Shirish, Ying, Weijiang, Gray, Felicia, Yao, Yiwu, Simes, Miranda L., Zhao, Qingjie, Miao, Hongzhi, Cho, Hyo Je, González-Alonso, Paula, Winkler, Alyssa, Lund, George, Purohit, Trupta, Kim, EunGi, Zhang, Xiaotian, Ray, Joshua M., He, Shihan, Nikolaidis, Caroline, Ndoj, Juliano, Wang, Jingya, Jaremko, Łukasz, Jaremko, Mariusz, Ryan, Russell J. H., Guzman, Monica L., Grembecka, Jolanta, Cierpicki, Tomasz

“…Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the…”
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Prostate cancer grade downgrading at time of prostatectomy provides risk‐stratification insight into future tumor behavior after prostatectomy by Wang, Shu, Ryan Russell, J., Drescher, Max, Park, Ashley, Legesse, Teklu, Kundra, Vikas, Tran, Phuoc T., Phelan, Michael, Naslund, Michael, Minhaj Siddiqui, M.

“…Background Prostate biopsy (Bx) sampling‐based diagnosis of prostate cancer (PCa) has well‐described inaccuracy when compared against whole gland analysis upon…”
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EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas by Ryan, Russell J H, Nitta, Mai, Borger, Darrell, Zukerberg, Lawrence R, Ferry, Judith A, Harris, Nancy Lee, Iafrate, A John, Bernstein, Bradley E, Sohani, Aliyah R, Le, Long Phi

“…Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and…”
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An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma by Drier, Yotam, Cotton, Matthew J, Williamson, Kaylyn E, Gillespie, Shawn M, Ryan, Russell J H, Kluk, Michael J, Carey, Christopher D, Rodig, Scott J, Sholl, Lynette M, Afrogheh, Amir H, Faquin, William C, Queimado, Lurdes, Qi, Jun, Wick, Michael J, El-Naggar, Adel K, Bradner, James E, Moskaluk, Christopher A, Aster, Jon C, Knoechel, Birgit, Bernstein, Bradley E

“…Bradley Bernstein, Birgit Knoechel and colleagues identify super-enhancer translocations that drive overexpression of MYB in adenoid cystic carcinoma (ACC)…”
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Genetic Events That Shape the Cancer Epigenome by Ryan, Russell J. H., Bernstein, Bradley E.

“…Mutations in chromatin-related genes in human tumors support a role for epigenetic mechanisms in driving cancer. Since the discovery of the first recurrent…”
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Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue With Amyloid Deposition: A Clinicopathologic Case Series by RYAN, Russell J. H, MARK SLOAN, J, BERNARD COLLINS, A, MANSOURI, Jaleh, RAJE, Noopur S, ZUKERBERG, Lawrence R, FERRY, Judith A

“…Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma is a mature B-cell neoplasm that typically follows an indolent clinical…”
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Fabrication of Poly(ethylene glycol) Hydrogel Microstructures Using Photolithography by Revzin, Alexander, Russell, Ryan J, Yadavalli, Vamsi K, Koh, Won-Gun, Deister, Curt, Hile, David D, Mellott, Michael B, Pishko, Michael V

“…The fabrication of hydrogel microstructures based upon poly(ethylene glycol) diacrylates, dimethacrylates, and tetraacrylates patterned photolithographically…”
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Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization by Huang, Guochang, Kaufman, Andrew J, Ryan, Russell J H, Romin, Yevgeniy, Huryn, Laryssa, Bains, Sarina, Manova-Todorova, Katia, Morris, Patricia L, Hunnicutt, Gary R, Adelman, Carrie A, Petrini, John H J, Ramanathan, Y, Singh, Bhuvanesh

“…Squamous cell carcinoma-related oncogene (SCCRO, also known as DCUN1D1) is a component of the E3 for neddylation. As such, DCUN1D1 regulates the neddylation of…”
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A Fluorescence-Based Glucose Biosensor Using Concanavalin A and Dextran Encapsulated in a Poly(ethylene glycol) Hydrogel by Russell, Ryan J, Pishko, Michael V, Gefrides, Christopher C, McShane, Michael J, Coté, Gerard L

“…A fluorescence biosensor is described that is based on a photopolymerized poly(ethylene glycol) (PEG) hydrogel incorporating fluorescein isothiocyanate dextran…”
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A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression by Gupta, Rajat M., Hadaya, Joseph, Trehan, Aditi, Zekavat, Seyedeh M., Roselli, Carolina, Klarin, Derek, Emdin, Connor A., Hilvering, Catharina R.E., Bianchi, Valerio, Mueller, Christian, Khera, Amit V., Ryan, Russell J.H., Engreitz, Jesse M., Issner, Robbyn, Shoresh, Noam, Epstein, Charles B., de Laat, Wouter, Brown, Jonathan D., Schnabel, Renate B., Bernstein, Bradley E., Kathiresan, Sekar

“…Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine…”
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Active surveillance in favorable intermediate risk prostate cancer: outstanding questions and controversies by Russell, J. Ryan, Siddiqui, M. Minhaj

“…Active surveillance has become the preferred management strategy for patients with low risk prostate cancer, but it is unclear if active surveillance can be…”
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A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes by van Galen, Peter, Viny, Aaron D., Ram, Oren, Ryan, Russell J.H., Cotton, Matthew J., Donohue, Laura, Sievers, Cem, Drier, Yotam, Liau, Brian B., Gillespie, Shawn M., Carroll, Kaitlin M., Cross, Michael B., Levine, Ross L., Bernstein, Bradley E.

“…Genome-wide profiling of histone modifications can provide systematic insight into the regulatory elements and programs engaged in a given cell type. However,…”
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The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and Other Hematopoietic Cancers by Monovich, Alexander C, Gurumurthy, Aishwarya, Ryan, Russell J H

“…Genetic alterations of the repressive ETS family transcription factor gene ETV6 are recurrent in several categories of hematopoietic malignancy, including…”
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Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress by Melnick, Ashley F, Mullin, Carea, Lin, Karena, McCarter, Anna C, Liang, Shannon, Liu, Yiran E, Wang, Qing, Jerome, Nicole A, Choe, Elizabeth, Kunnath, Nicholas, Bodanapu, Geethika, Akter, Fatema, Magnuson, Brian, Kumar, Surinder, Lombard, David B, Muntean, Andrew G, Ljungman, Mats, Sekiguchi, JoAnn, Ryan, Russell J H, Chiang, Mark Y

“…Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL), but pan-Notch inhibitors showed excessive toxicity in clinical…”
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EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma by Apfelbaum, April A, Wu, Feinan, Hawkins, Allegra G, Magnuson, Brian, Jiménez, Jennifer A, Taylor, Sean D, Wrenn, Emma D, Waltner, Olivia, Pfaltzgraff, Elise R, Song, Jane Y, Hall, Cody, Wellik, Deneen M, Ljungman, Mats, Furlan, Scott N, Ryan, Russell J H, Sarthy, Jay F, Lawlor, Elizabeth R

“…Propagation of Ewing sarcoma requires precise regulation of EWS::FLI1 transcriptional activity. Determining the mechanisms of fusion regulation will advance…”
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Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma by Ryan, Russell J H, Drier, Yotam, Whitton, Holly, Cotton, M Joel, Kaur, Jasleen, Issner, Robbyn, Gillespie, Shawn, Epstein, Charles B, Nardi, Valentina, Sohani, Aliyah R, Hochberg, Ephraim P, Bernstein, Bradley E

“…B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel…”
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Poly(ethylene glycol) Hydrogel-Encapsulated Fluorophore−Enzyme Conjugates for Direct Detection of Organophosphorus Neurotoxins by Russell, Ryan J, Pishko, Michael V, Simonian, Aleksandr L, Wild, James R

“…A simple approach is described for preparing poly(ethylene glycol) hydrogel materials with encapsulated seminapthofluorescein (SNAFL)−organophosphorus…”
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IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes by Restivo, Gaetana, Nguyen, Bach-Cuc, Dziunycz, Piotr, Ristorcelli, Elodie, Ryan, Russell J H, Özuysal, Özden Yalçin, Di Piazza, Matteo, Radtke, Freddy, Dixon, Michael J, Hofbauer, Günther F L, Lefort, Karine, Dotto, G Paolo

“…While the pro‐differentiation and tumour suppressive functions of Notch signalling in keratinocytes are well established, the underlying mechanisms remain…”
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