Search Results - "Russell, Roslin"

Intestinal label-retaining cells are secretory precursors expressing Lgr5 by Buczacki, Simon J. A., Zecchini, Heather Ireland, Nicholson, Anna M., Russell, Roslin, Vermeulen, Louis, Kemp, Richard, Winton, Douglas J.

“…The rapid cell turnover of the intestinal epithelium is achieved from small numbers of stem cells located in the base of glandular crypts. These stem cells…”
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Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties by Donati, Giacomo, Rognoni, Emanuel, Hiratsuka, Toru, Liakath-Ali, Kifayathullah, Hoste, Esther, Kar, Gozde, Kayikci, Melis, Russell, Roslin, Kretzschmar, Kai, Mulder, Klaas W., Teichmann, Sarah A., Watt, Fiona M.

“…The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that…”
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Copynumber: Efficient algorithms for single- and multi-track copy number segmentation by Nilsen, Gro, Liestøl, Knut, Van Loo, Peter, Moen Vollan, Hans Kristian, Eide, Marianne B, Rueda, Oscar M, Chin, Suet-Feung, Russell, Roslin, Baumbusch, Lars O, Caldas, Carlos, Børresen-Dale, Anne-Lise, Lingjaerde, Ole Christian

“…Cancer progression is associated with genomic instability and an accumulation of gains and losses of DNA. The growing variety of tools for measuring genomic…”
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Identification of candidate causal variants and target genes at 41 breast cancer risk loci through differential allelic expression analysis by Xavier, Joana M., Magno, Ramiro, Russell, Roslin, de Almeida, Bernardo P., Jacinta-Fernandes, Ana, Besouro-Duarte, André, Dunning, Mark, Samarajiwa, Shamith, O’Reilly, Martin, Maia, António M., Rocha, Cátia L., Rosli, Nordiana, Ponder, Bruce A. J., Maia, Ana-Teresa

“…Understanding breast cancer genetic risk relies on identifying causal variants and candidate target genes in risk loci identified by genome-wide association…”
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Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17 by Hu, Dong G, Selth, Luke A, Tarulli, Gerard A, Meech, Robyn, Wijayakumara, Dhilushi, Chanawong, Apichaya, Russell, Roslin, Caldas, Carlos, Robinson, Jessica L L, Carroll, Jason S, Tilley, Wayne D, Mackenzie, Peter I, Hickey, Theresa E

“…Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby influencing carcinogenesis in…”
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Double-stranded microRNA mimics can induce length- and passenger strand-dependent effects in a cell type-specific manner by Goldgraben, Mae A, Russell, Roslin, Rueda, Oscar M, Caldas, Carlos, Git, Anna

“…MicroRNAs are short (17-26) noncoding RNAs driving or modulating physiological and pathological cellular events. Overexpression of miR-155 is pathogenic in…”
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APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer by Periyasamy, Manikandan, Patel, Hetal, Lai, Chun-Fui, Nguyen, Van T.M., Nevedomskaya, Ekaterina, Harrod, Alison, Russell, Roslin, Remenyi, Judit, Ochocka, Anna Maria, Thomas, Ross S., Fuller-Pace, Frances, Győrffy, Balázs, Caldas, Carlos, Navaratnam, Naveenan, Carroll, Jason S., Zwart, Wilbert, Coombes, R. Charles, Magnani, Luca, Buluwela, Laki, Ali, Simak

“…Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation…”
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Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer by Abdel-Fatah, Tarek M.A., Russell, Roslin, Albarakati, Nada, Maloney, David J., Dorjsuren, Dorjbal, Rueda, Oscar M., Moseley, Paul, Mohan, Vivek, Sun, Hongmao, Abbotts, Rachel, Mukherjee, Abhik, Agarwal, Devika, Illuzzi, Jennifer L., Jadhav, Ajit, Simeonov, Anton, Ball, Graham, Chan, Stephen, Caldas, Carlos, Ellis, Ian O., Wilson, David M., Madhusudan, Srinivasan

“…FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance of…”
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Expression of androgen receptor splice variants in clinical breast cancers by Hickey, Theresa E, Irvine, Connie M, Dvinge, Heidi, Tarulli, Gerard A, Hanson, Adrienne R, Ryan, Natalie K, Pickering, Marie A, Birrell, Stephen N, Hu, Dong Gui, Mackenzie, Peter I, Russell, Roslin, Caldas, Carlos, Raj, Ganesh V, Dehm, Scott M, Plymate, Stephen R, Bradley, Robert K, Tilley, Wayne D, Selth, Luke A

“…The importance of androgen receptor (AR) signaling is increasingly being recognized in breast cancer, which has elicited clinical trials aimed at assessing the…”
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Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes by Joseph, Chitra, Macnamara, Olivia, Craze, Madeleine, Russell, Roslin, Provenzano, Elena, Nolan, Christopher C., Diez-Rodriguez, Maria, Sonbul, Sultan N., Aleskandarany, Mohammed A., Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Mukherjee, Abhik

“…Background Mediator complex (MED) proteins have a key role in transcriptional regulation, some interacting with the oestrogen receptor (ER). Interrogation of…”
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Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy by Albarakati, Nada, Abdel-Fatah, Tarek M.A., Doherty, Rachel, Russell, Roslin, Agarwal, Devika, Moseley, Paul, Perry, Christina, Arora, Arvind, Alsubhi, Nouf, Seedhouse, Claire, Rakha, Emad A., Green, Andrew, Ball, Graham, Chan, Stephen, Caldas, Carlos, Ellis, Ian O., Madhusudan, Srinivasan

“…BRCA1, a key factor in homologous recombination (HR) repair may also regulate base excision repair (BER). Targeting BRCA1-BER deficient cells by blockade of…”
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Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer by Ben-Chetrit, Nir, Chetrit, David, Russell, Roslin, Körner, Cindy, Mancini, Maicol, Abdul-Hai, Ali, Itkin, Tomer, Carvalho, Silvia, Cohen-Dvashi, Hadas, Koestler, Wolfgang J, Shukla, Kirti, Lindzen, Moshit, Kedmi, Merav, Lauriola, Mattia, Shulman, Ziv, Barr, Haim, Seger, Dalia, Ferraro, Daniela A, Pareja, Fresia, Gil-Henn, Hava, Lapidot, Tsvee, Alon, Ronen, Milanezi, Fernanda, Symons, Marc, Ben-Hamo, Rotem, Efroni, Sol, Schmitt, Fernando, Wiemann, Stefan, Caldas, Carlos, Ehrlich, Marcelo, Yarden, Yosef

“…Amplified HER2, which encodes a member of the epidermal growth factor receptor (EGFR) family, is a target of effective therapies against breast cancer. In…”
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HES6 drives a critical AR transcriptional programme to induce castration‐resistant prostate cancer through activation of an E2F1‐mediated cell cycle network by Ramos‐Montoya, Antonio, Lamb, Alastair D, Russell, Roslin, Carroll, Thomas, Jurmeister, Sarah, Galeano‐Dalmau, Nuria, Massie, Charlie E, Boren, Joan, Bon, Helene, Theodorou, Vasiliki, Vias, Maria, Shaw, Greg L, Sharma, Naomi L, Ross‐Adams, Helen, Scott, Helen E, Vowler, Sarah L, Howat, William J, Warren, Anne Y, Wooster, Richard F, Mills, Ian G, Neal, David E

“…Castrate‐resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other…”
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Navigator‐3, a modulator of cell migration, may act as a suppressor of breast cancer progression by Cohen‐Dvashi, Hadas, Ben‐Chetrit, Nir, Russell, Roslin, Carvalho, Silvia, Lauriola, Mattia, Nisani, Sophia, Mancini, Maicol, Nataraj, Nishanth, Kedmi, Merav, Roth, Lee, Köstler, Wolfgang, Zeisel, Amit, Yitzhaky, Assif, Zylberg, Jacques, Tarcic, Gabi, Eilam, Raya, Wigelman, Yoav, Will, Rainer, Lavi, Sara, Porat, Ziv, Wiemann, Stefan, Ricardo, Sara, Schmitt, Fernando, Caldas, Carlos, Yarden, Yosef

“…Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we identify Navigator‐3 ( NAV3 ), a gene frequently mutated or deleted…”
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SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis by Abdel-Fatah, Tarek M A, PhD, Agarwal, Devika, MSc, Liu, Dong-Xu, PhD, Russell, Roslin, PhD, Rueda, Oscar M, PhD, Liu, Karen, MSc, Xu, Bing, PhD, Moseley, Paul M, BSc, Green, Andrew R, PhD, Pockley, Alan G, Prof, Rees, Robert C, Prof, Caldas, Carlos, Prof, Ellis, Ian O, Prof, Ball, Graham R, Prof, Chan, Stephen Y T, Prof

“…Summary Background Proliferation markers and profiles have been recommended for guiding the choice of systemic treatments for breast cancer. However, the best…”
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DNA polymerase β deficiency is linked to aggressive breast cancer: A comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts by Abdel-Fatah, Tarek M.A., Russell, Roslin, Agarwal, Devika, Moseley, Paul, Abayomi, Michael Ayotunde, Perry, Christina, Albarakati, Nada, Ball, Graham, Chan, Stephen, Caldas, Carlos, Ellis, Ian O., Madhusudan, Srinivasan

“…Short arm of chromosome 8 is a hot spot for chromosomal breaks, losses and amplifications in breast cancer. Although such genetic changes may have phenotypic…”
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Role of Hes6 in castration-resistant prostate cancer by Lamb, Alastair D, Dr, Ramos-Montoya, Antonio, PhD, Russell, Roslin, PhD, Carroll, Thomas, PhD, Massie, Charlie E, PhD, Shaw, Greg L, MD, Sharma, Naomi L, MD, Warren, Anne Y, MD, Mills, Ian G, PhD, Neal, David E, Prof

“…Abstract Background Castration-resistant prostate cancer is a heterogeneous conditon that is poorly characterised. Although the androgen receptor (AR) is of…”
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Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping by Abraham, Jean E, Maranian, Mel J, Spiteri, Inmaculada, Russell, Roslin, Ingle, Susan, Luccarini, Craig, Earl, Helena M, Pharoah, Paul P D, Dunning, Alison M, Caldas, Carlos

“…The increasing trend for incorporation of biological sample collection within clinical trials requires sample collection procedures which are convenient and…”
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Microarray oligonucleotide probes by Kreil, David P, Russell, Roslin R, Russell, Steven

“…Oligonucleotide probes are increasingly the method of choice for many modern DNA microarray applications. They provide higher target specificity, probe…”
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There is no silver bullet: a guide to low-level data transforms and normalisation methods for microarray data by KREIL, David P, RUSSELL, Roslin R

“…To overcome random experimental variation, even for simple screens, data from multiple microarrays have to be combined. There are, however, systematic…”
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