Search Results - "Russell, Robert B"

Next Generation Protein Structure Predictions and Genetic Variant Interpretation by Diwan, Gaurav D., Gonzalez-Sanchez, Juan Carlos, Apic, Gordana, Russell, Robert B.

“…[Display omitted] •Alphafold represents a major advance in computational biology in that it is now possible to predict protein topologies accurately from amino…”
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WeSA: a web server for improving analysis of affinity proteomics data by Shtetinska, Magdalena M, González-Sánchez, Juan-Carlos, Beyer, Tina, Boldt, Karsten, Ueffing, Marius, Russell, Robert B

“…Protein-protein interaction experiments still yield many false positive interactions. The socioaffinity metric can distinguish true protein-protein…”
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Biochemically validated structural model of the 15‐subunit intraflagellar transport complex IFT‐B by Petriman, Narcis A, Loureiro‐López, Marta, Taschner, Michael, Zacharia, Nevin K, Georgieva, Magdalena M, Boegholm, Niels, Wang, Jiaolong, Mourão, André, Russell, Robert B, Andersen, Jens S, Lorentzen, Esben

“…Cilia are ubiquitous eukaryotic organelles impotant for cellular motility, signaling, and sensory reception. Cilium formation requires intraflagellar transport…”
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PRECOGx: exploring GPCR signaling mechanisms with deep protein representations by Matic, Marin, Singh, Gurdeep, Carli, Francesco, De Oliveira Rosa, Natalia, Miglionico, Pasquale, Magni, Lorenzo, Gutkind, J Silvio, Russell, Robert B, Inoue, Asuka, Raimondi, Francesco

“…Abstract In this study we show that protein language models can encode structural and functional information of GPCR sequences that can be used to predict…”
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Landscape of nuclear transport receptor cargo specificity by Mackmull, Marie‐Therese, Klaus, Bernd, Heinze, Ivonne, Chokkalingam, Manopriya, Beyer, Andreas, Russell, Robert B, Ori, Alessandro, Beck, Martin

“…Nuclear transport receptors (NTRs) recognize localization signals of cargos to facilitate their passage across the central channel of nuclear pore complexes…”
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Principles of microRNA-target recognition by Brennecke, Julius, Stark, Alexander, Russell, Robert B, Cohen, Stephen M

“…MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression in plants and animals. Although their biological importance has become clear, how…”
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Systematic Discovery of In Vivo Phosphorylation Networks by Linding, Rune, Jensen, Lars Juhl, Ostheimer, Gerard J., van Vugt, Marcel A.T.M., Jørgensen, Claus, Miron, Ioana M., Diella, Francesca, Colwill, Karen, Taylor, Lorne, Elder, Kelly, Metalnikov, Pavel, Nguyen, Vivian, Pasculescu, Adrian, Jin, Jing, Park, Jin Gyoon, Samson, Leona D., Woodgett, James R., Russell, Robert B., Bork, Peer, Yaffe, Michael B., Pawson, Tony

“…Protein kinases control cellular decision processes by phosphorylating specific substrates. Thousands of in vivo phosphorylation sites have been identified,…”
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PRECOG: PREdicting COupling probabilities of G-protein coupled receptors by Singh, Gurdeep, Inoue, Asuka, Gutkind, J Silvio, Russell, Robert B, Raimondi, Francesco

“…G-protein coupled receptors (GPCRs) control multiple physiological states by transducing a multitude of extracellular stimuli into the cell via coupling to…”
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Accurate prediction of peptide binding sites on protein surfaces by Petsalaki, Evangelia, Stark, Alexander, García-Urdiales, Eduardo, Russell, Robert B

“…Many important protein-protein interactions are mediated by the binding of a short peptide stretch in one protein to a large globular segment in another…”
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Capturing protein communities by structural proteomics in a thermophilic eukaryote by Kastritis, Panagiotis L, O'Reilly, Francis J, Bock, Thomas, Li, Yuanyue, Rogon, Matt Z, Buczak, Katarzyna, Romanov, Natalie, Betts, Matthew J, Bui, Khanh Huy, Hagen, Wim J, Hennrich, Marco L, Mackmull, Marie‐Therese, Rappsilber, Juri, Russell, Robert B, Bork, Peer, Beck, Martin, Gavin, Anne‐Claude

“…The arrangement of proteins into complexes is a key organizational principle for many cellular functions. Although the topology of many complexes has been…”
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Cryptogenic cholestasis in young and adults: ATP8B1, ABCB11, ABCB4, and TJP2 gene variants analysis by high-throughput sequencing by Vitale, Giovanni, Gitto, Stefano, Raimondi, Francesco, Mattiaccio, Alessandro, Mantovani, Vilma, Vukotic, Ranka, D’Errico, Antonietta, Seri, Marco, Russell, Robert B., Andreone, Pietro

“…Background Mutations in ATP-transporters ATPB81 , ABCB11 , and ABCB4 are responsible for progressive familial intrahepatic cholestasis (PFIC) 1, 2 and 3, and…”
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Molecular dissection of human Argonaute proteins by DNA shuffling by Schürmann, Nina, Trabuco, Leonardo G, Bender, Christian, Russell, Robert B, Grimm, Dirk

“…What makes human Argonaute 2 (Ago2) slicing competent in contrast to AGO1, 3 and 4, which lack RNA cleavage activity, has remained unclear. Now, a molecular…”
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Interrogating Protein Interaction Networks through Structural Biology by Aloy, Patrick, Russell, Robert B.

“…Protein-protein interactions are central to most biological processes. Although much recent effort has been put into methods to identify interacting partners,…”
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Mechnetor: a web server for exploring protein mechanism and the functional context of genetic variants by González-Sánchez, Juan Carlos, Ibrahim, Mustafa F R, Leist, Ivo C, Weise, Kyle R, Russell, Robert B

“…Abstract Advances in DNA sequencing and proteomics mean that researchers must now regularly interrogate thousands of positional gene/protein changes in order…”
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Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions by Betts, Matthew J, Lu, Qianhao, Jiang, YingYing, Drusko, Armin, Wichmann, Oliver, Utz, Mathias, Valtierra-Gutiérrez, Ilse A, Schlesner, Matthias, Jaeger, Natalie, Jones, David T, Pfister, Stefan, Lichter, Peter, Eils, Roland, Siebert, Reiner, Bork, Peer, Apic, Gordana, Gavin, Anne-Claude, Russell, Robert B

“…Systematic interrogation of mutation or protein modification data is important to identify sites with functional consequences and to deduce global consequences…”
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Identification of Drosophila MicroRNA targets by Stark, Alexander, Brennecke, Julius, Russell, Robert B, Cohen, Stephen M

“…MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression by binding to target messenger RNAs and by controlling protein production or causing…”
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The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes by Porcellato, Elena, González-Sánchez, Juan Carlos, Ahlmann-Eltze, Constantin, Elsakka, Mahmoud Ali, Shapira, Itamar, Fritsch, Jürgen, Navarro, Juan Antonio, Anders, Simon, Russell, Robert B, Wieland, Felix T, Metzendorf, Christoph

“…Protein S-palmitoylation, the addition of a long-chain fatty acid to target proteins, is among the most frequent reversible protein modifications in Metazoa,…”
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Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm by Raimondi, Francesco, Inoue, Asuka, Kadji, Francois M. N., Shuai, Ni, Gonzalez, Juan-Carlos, Singh, Gurdeep, de la Vega, Alicia Alonso, Sotillo, Rocio, Fischer, Bernd, Aoki, Junken, Gutkind, J. Silvio, Russell, Robert B.

“…Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or repression of key…”
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Systematic identification of phosphorylation-mediated protein interaction switches by Betts, Matthew J, Wichmann, Oliver, Utz, Mathias, Andre, Timon, Petsalaki, Evangelia, Minguez, Pablo, Parca, Luca, Roth, Frederick P, Gavin, Anne-Claude, Bork, Peer, Russell, Robert B

“…Proteomics techniques can identify thousands of phosphorylation sites in a single experiment, the majority of which are new and lack precise information about…”
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Cross‐talk between phosphorylation and lysine acetylation in a genome‐reduced bacterium by van Noort, Vera, Seebacher, Jan, Bader, Samuel, Mohammed, Shabaz, Vonkova, Ivana, Betts, Matthew J, Kühner, Sebastian, Kumar, Runjun, Maier, Tobias, O'Flaherty, Martina, Rybin, Vladimir, Schmeisky, Arne, Yus, Eva, Stülke, Jörg, Serrano, Luis, Russell, Robert B, Heck, Albert JR, Bork, Peer, Gavin, Anne‐Claude

“…Protein post‐translational modifications (PTMs) represent important regulatory states that when combined have been hypothesized to act as molecular codes and…”
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