Search Results - "Russell, R.A."

Renaissance of α-Methylene-γ-butyrolactones: New Synthetic Approaches by Kitson, Russell R.A, Millemaggi, Alessia, Taylor, Richard J.K

“…The amount of research activity concerning α-methylene-γ-butyrolactones and α-alkylidene-γ-butyrolactones has increased dramatically in recent years. This…”
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Characterization of Kentucky dairy producer decision-making behavior by Russell, R A, Bewley, J M

“…To address dairy clientele needs, industry professionals need to understand how dairy producers make decisions. A survey was distributed to all licensed…”
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Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement by David, Nadège, Pasceri, Raffaele, Kitson, Russell R. A., Pradal, Alexandre, Moody, Christopher J.

“…A short formal total synthesis of the marine natural product diazonamide A is described. The route is based on indole oxidative rearrangement, and a number of…”
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Telescoped Intramolecular Michael/Olefination (TIMO) Approach to α-Alkylidene-γ-butyrolactones: Synthesis of (+)-Paeonilactone B by Edwards, Michael G, Kenworthy, Martin N, Kitson, Russell R.A, Scott, Mark S, Taylor, Richard J.K

“…Scoping out TIMO: A telescoped intramolecular Michael addition/proton transfer/Horner–Wadsworth–Emmons olefination sequence was developed to provide rapid…”
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Producer assessment of dairy extension programming in Kentucky by Russell, R A, Bewley, J M

“…To assess the dairy production issues extension programming should be addressing, a survey was distributed to all licensed milk producers in Kentucky…”
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The Akoya pearl oyster shell as an archival monitor of lead exposure by MacFarlane, G.R., Markich, S.J., Linz, K., Gifford, S., Dunstan, R.H., O'Connor, W., Russell, R.A.

“…The Akoya pearl oyster ( Pinctada imbricata) was experimentally exposed to (a) constant levels of lead (Pb) at 180 μg L −1 for nine weeks, or (b) two short…”
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Synthesis of novel geldanamycin derivatives by Kitson, Russell R.A., Moody, Christopher J.

“…The toxicity associated with the geldanamycin family of benzoquinone ansamycins when used as heat shock protein-90 inhibitor molecular therapeutics is…”
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Quinone Synthesis and a Visual Introduction to Column Chromatography: An Undergraduate Experiment by Pearson, Danielle L., Kitson, Russell R. A.

“…An introductory normal phase column chromatography experiment is described and evaluated for second year undergraduate chemistry laboratory class. The…”
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2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1 by Finger, Vladimir, Kucera, Tomas, Kafkova, Radka, Muckova, Lubica, Dolezal, Rafael, Kubes, Jan, Novak, Martin, Prchal, Lukas, Lakatos, Levente, Andrs, Martin, Hympanova, Michaela, Marek, Jan, Kufa, Martin, Spiwok, Vojtech, Soukup, Ondrej, Mezeiova, Eva, Janousek, Jiri, Nevosadova, Lenka, Benkova, Marketa, Kitson, Russell R.A., Kratky, Martin, Bősze, Szilvia, Mikusova, Katarina, Hartkoorn, Ruben, Roh, Jaroslav, Korabecny, Jan

“…Phenotypic screening of an in-house library of small molecule purine derivatives against Mycobacterium tuberculosis (Mtb) led to the identification of…”
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Learning from Nature: Advances in Geldanamycin- and Radicicol-Based Inhibitors of Hsp90 by Kitson, Russell R. A, Moody, Christopher J

“…Natural products have been fundamental in the development of new therapeutic agents predicated on the inhibition of heat shock protein 90 (Hsp90). This…”
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Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway by Karabanovich, Galina, Fabiánová, Viktória, Vocat, Anthony, Dušek, Jan, Valášková, Lenka, Stolaříková, Jiřina, Kitson, Russell R. A., Pávek, Petr, Vávrová, Kateřina, Djaout, Kamel, Mikušová, Katarína, Baulard, Alain R., Cole, Stewart T., Korduláková, Jana, Roh, Jaroslav

“…3,5-Dinitrobenzylsulfanyl tetrazoles and 1,3,4-oxadiazoles, previously identified as having high in vitro activities against both replicating and…”
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The Black Student Experience: Comparing STEM Undergraduate Student Experiences at Higher Education Institutions of Varying Student Demographic by Greaves, Racheal, Kelestyn, Bozhena, Blackburn, Richard A. R, Kitson, Russell R. A

“…Although having shown signs of closing in recent years, the Black attainment gap in UK Higher Education continues to be significant and, as such, has received…”
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‘They help us realise what we’re actually gaining’: The impact on undergraduates and teaching staff of displaying transferable skills badges by Hill, Michelle A, Overton, Tina, Kitson, Russell RA, Thompson, Christopher D, Brookes, Rowan H, Coppo, Paolo, Bayley, Lynne

“…Attaining transferable skills is increasingly important for undergraduates and, while such skill development may be embedded within the curriculum, it is often…”
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Back Cover: Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement (Chem. Eur. J. 31/2016) by David, Nadège, Pasceri, Raffaele, Kitson, Russell R. A., Pradal, Alexandre, Moody, Christopher J.

“…Pin ups! The cover picture shows pin ups of the structure of marine natural product diazonamide A, the pivotal oxindole intermediate, and a post‐it showing the…”
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A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity by Xiong, Rui, Zhou, Wenbo, Siegel, David, Kitson, Russell R A, Freed, Curt R, Moody, Christopher J, Ross, David

“…A potential cause of neurodegenerative diseases, including Parkinson's disease (PD), is protein misfolding and aggregation that in turn leads to neurotoxicity…”
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Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90 by Kitson, Russell R. A., Chang, Chuan-Hsin, Xiong, Rui, Williams, Huw E. L., Davis, Adrienne L., Lewis, William, Dehn, Donna L., Siegel, David, Roe, S. Mark, Prodromou, Chrisostomos, Ross, David, Moody, Christopher J.

“…The benzoquinone ansamycin geldanamycin and its derivatives are inhibitors of heat shock protein Hsp90, an emerging target for novel therapeutic agents both in…”
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Toward the Total Synthesis of Hygrocin B and Divergolide C: Construction of the Naphthoquinone–Azepinone Core by Nawrat, Christopher C, Kitson, Russell R. A, Moody, Christopher J

“…A highly regioselective Diels–Alder approach toward the bioactive natural products hygrocin B and divergolide C is presented. The route uses an unusual…”
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Synthesis of toxyloxanthone B by Giallombardo, Daniele, Nevin, Adam C., Lewis, William, Nawrat, Christopher C., Kitson, Russell R.A., Moody, Christopher J.

“…A synthesis of the naturally occurring xanthone toxyloxanthone B is described, in which the key step is the regioselective addition of a methyl salicylate to a…”
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Undergraduate Recognition of Curriculum-Related Skill Development and the Skills Employers Are Seeking by Hill, Michelle A, Overton, Tina L, Thompson, Christopher D, Kitson, Russell R. A, Coppo, Paolo

“…Employers of chemistry graduates are seeking a range of transferable skills from prospective employees, and academics are increasingly seeking to build…”
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An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration by Kitson, Russell R A, Moody, Christopher J

“…19-Substituted geldanamycin derivatives are efficient Hsp90 inhibitors, without the toxicity associated with the other benzoquinone ansamycins, thus giving…”
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