Search Results - "Russell, Patricia K."

A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis by Clarke, Michele V, Russell, Patricia K, Findlay, David M, Sastra, Stephen, Anderson, Paul H, Skinner, Jarrod P, Atkins, Gerald J, Zajac, Jeffrey D, Davey, Rachel A

“…During lactation, the large transfer of calcium from the mother to the milk is primarily sourced from the maternal skeleton. To determine whether the…”
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The androgen receptor in the hypothalamus positively regulates hind-limb muscle mass and voluntary physical activity in adult male mice by Clarke, Michele V., Russell, Patricia K., Zajac, Jeffrey D., Davey, Rachel A.

“…•Deletion of the androgen receptor in the hypothalamus decreases skeletal muscle mass.•Hypothalamic-androgen receptor knockout mice exhibit decreased voluntary…”
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Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice by Davey, Rachel A, Clarke, Michele V, Russell, Patricia K, Rana, Kesha, Seto, Jane, Roeszler, Kelly N, How, Jackie M.Y, Chia, Ling Yeong, North, Kathryn, Zajac, Jeffrey D

“…Although it is well established that exogenous androgens have anabolic effects on skeletal muscle mass in humans and mice, data from muscle-specific androgen…”
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Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice by Russell, Patricia K, Clarke, Michele V, Skinner, Jarrod P, Pang, Tammy P S, Zajac, Jeffrey D, Davey, Rachel A

“…Androgens play a key role in skeletal growth and maintenance in males and can mediate their actions, at least in part, via the androgen receptor (AR) in…”
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Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia by Moreira, Lucia M., Takawale, Abhijit, Hulsurkar, Mohit, Menassa, David A., Antanaviciute, Agne, Lahiri, Satadru K., Mehta, Neelam, Evans, Neil, Psarros, Constantinos, Robinson, Paul, Sparrow, Alexander J., Gillis, Marc-Antoine, Ashley, Neil, Naud, Patrice, Barallobre-Barreiro, Javier, Theofilatos, Konstantinos, Lee, Angela, Norris, Mary, Clarke, Michele V., Russell, Patricia K., Casadei, Barbara, Bhattacharya, Shoumo, Zajac, Jeffrey D., Davey, Rachel A., Sirois, Martin, Mead, Adam, Simmons, Alison, Mayr, Manuel, Sayeed, Rana, Krasopoulos, George, Redwood, Charles, Channon, Keith M., Tardif, Jean-Claude, Wehrens, Xander H. T., Nattel, Stanley, Reilly, Svetlana

“…Atrial fibrillation, the most common cardiac arrhythmia, is an important contributor to mortality and morbidity, and particularly to the risk of stroke in…”
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The calcitonin receptor regulates osteocyte lacunae acidity during lactation in mice by Davey, Rachel A, Clarke, Michele V, Golub, Suzanne B, Russell, Patricia K, Zajac, Jeffrey D

“…The physiological role of calcitonin, and its receptor, the CTR (or Calcr), has long been debated. We previously provided the first evidence for a…”
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Vitamin D receptor expression in mature osteoclasts reduces bone loss due to low dietary calcium intake in male mice by Starczak, Yolandi, Reinke, Daniel C., Barratt, Kate R., Russell, Patricia K., Clarke, Michelle V., Davey, Rachel A., Atkins, Gerald J., Anderson, Paul H.

“…Mature osteoclasts express the vitamin D receptor (VDR) and are able to respond to active vitamin D (1α, 25-dihydroxyvitamin D3; 1,25(OH)2D3) by regulating…”
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The AR in bone marrow progenitor cells protects against short-term high-caloric diet-induced weight gain in male mice by Venkatesh, Varun S, Russell, Patricia K, Fam White, Barbara, Clarke, Michele V, Golub, Suzanne, Mangiofico, Salvatore, Haralambous, Christian, Lokan, Julie, Andrikopoulos, Sof, Zajac, Jeffrey D, Davey, Rachel A

“…We previously identified a novel pathway of testosterone action via the androgen receptor (AR) in bone marrow mesenchymal precursor cells (BM-PCs) to…”
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Absence of vitamin D receptor in mature osteoclasts results in altered osteoclastic activity and bone loss by Starczak, Yolandi, Reinke, Daniel C., Barratt, Kate R., Ryan, Jackson W., Russell, Patricia K., Clarke, Michele V., St-Arnaud, René, Morris, Howard A., Davey, Rachel A., Atkins, Gerald J., Anderson, Paul H.

“…•The deletion of vitamin D receptor in osteoclasts results in femoral bone loss.•Osteoclast-specific VDRKO mice exhibit a marked reduction in thin trabeculae…”
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Muscle-specific androgen receptor deletion shows limited actions in myoblasts but not in myofibers in different muscles in vivo by Rana, Kesha, Chiu, Maria W S, Russell, Patricia K, Skinner, Jarrod P, Lee, Nicole K L, Fam, Barbara C, Zajac, Jeffrey D, MacLean, Helen E

“…The aim of this study was to investigate the direct muscle cell-mediated actions of androgens by comparing two different mouse lines. The cre-loxP system was…”
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The androgen receptor in bone marrow progenitor cells negatively regulates fat mass by Russell, Patricia K, Mangiafico, Salvatore, Fam, Barbara C, Clarke, Michele V, Marin, Evelyn S, Andrikopoulos, Sofianos, Wiren, Kristine M, Zajac, Jeffrey D, Davey, Rachel A

“…It is well established that testosterone negatively regulates fat mass in humans and mice; however, the mechanism by which testosterone exerts these effects is…”
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Androgen Receptor Action in Osteoblasts in Male Mice Is Dependent on Their Stage of Maturation by Russell, Patricia K, Clarke, Michele V, Cheong, Karey, Anderson, Paul H, Morris, Howard A, Wiren, Kristine M, Zajac, Jeffrey D, Davey, Rachel A

“…ABSTRACT Androgen action via the androgen receptor (AR) is essential for normal skeletal growth and bone maintenance post‐puberty in males; however, the…”
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The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1 by Bauskin, Asne R., Zhang, Hong-Ping, Fairlie, W.Douglas, He, Xiao Yan, Russell, Patricia K., Moore, Anthony G., Brown, David A., Stanley, Keith K., Breit, Samuel N.

“…Macrophage inhibitory cytokine (MIC‐1), a divergent member of the transforming growth factor‐β (TGF‐β) superfamily and activation associated cytokine, is…”
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Epitope Mapping of the Transforming Growth Factor-β Superfamily Protein, Macrophage Inhibitory Cytokine-1 (MIC-1):  Identification of at Least Five Distinct Epitope Specificities by Fairlie, W. Douglas, Russell, Patricia K, Wu, Wan M, Moore, Anthony G, Zhang, Hong-Ping, Brown, Peter K, Bauskin, Asne R, Breit, Samuel N

“…Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the transforming growth factor-β (TGF-β) superfamily whose increased expression is associated…”
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Calcitonin paracrine signaling controls heart fibrogenesis and arrhythmia by Moreira, Lucia, Takawale, Abhijit, Menassa, David A., Psarros, Constantinos, Mehta, Neelam, Evans, Neil, Gillis, Marc-Antoine, Lee, Angela, Naud, Patrice, Norris, Mary, Clarke, Michele V., Russell, Patricia K., Casadei, Barbara, Bhattacharya, Shoumo, Zajac, Jeffrey D., Davey, Rachel A., Sirois, Martin, Sayeed, Rana, Krasopoulos, George, Redwood, Charles, Channon, Keith, Tardif, Jean-Claud, Nattel, Stanley, Reilly, Svetlana

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Screening procedure for Pichia pastoris clones containing multiple copy gene inserts by Fairlie, W D, Russell, P K, Zhang, H P, Breit, S N

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The Androgen Receptor in the hypothalamus positively regulates hind-limb muscle mass and voluntary physical activity in male mice by Clarke, Michele V, Russell, Patricia K, Zajac, Jeffrey D, Davey, Rachel A

“…We have previously shown that expression of the androgen receptor (AR) in neurons within the brain positively regulates hind-limb muscle mass and physical…”
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The Propeptide of the Transforming Growth Factor-β Superfamily Member, Macrophage Inhibitory Cytokine-1 (MIC-1), Is a Multifunctional Domain That Can Facilitate Protein Folding and Secretion by Fairlie, W. Douglas, Zhang, Hong-Ping, Wu, Wan M., Pankhurst, Susan L., Bauskin, Asne R., Russell, Patricia K., Brown, Peter K., Breit, Samuel N.

“…Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the transforming growth factor-β (TGF-β) superfamily. While it is synthesized in a pre-pro…”
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Expression of a TGF-β superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris by Fairlie, W.Douglas, Zhang, Hong-Ping, Brown, Peter K., Russell, Patricia K., Bauskin, Asne R., Breit, Samuel N.

“…The methylotrophic yeast, Pichia pastoris, has been used to express both human and murine macrophage inhibitory cytokine-1 (MIC-1), a transforming growth…”
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The Propeptide of the Transforming Growth Factor-β Superfamily Member, Macrophage Inhibitory Cytokine-1 (MIC-1), Is a Multifunctional Domain That Can Facilitate Protein Folding and Secretion by W. Douglas Fairlie, Hong-Ping Zhang, Wan M. Wu, Susan L. Pankhurst, Asne R. Bauskin, Patricia K. Russell, Peter K. Brown, Samuel N. Breit

“…Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the transforming growth factor-β (TGF-β) superfamily. While it is synthesized in a pre-pro…”
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