Search Results - "Russell, Matthew R"

Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages by Greenwood, Daniel J, Dos Santos, Mariana Silva, Huang, Song, Russell, Matthew R G, Collinson, Lucy M, MacRae, James I, West, Andy, Jiang, Haibo, Gutierrez, Maximiliano G

“…Tuberculosis, caused by the intracellular pathogen , remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of…”
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Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics by Achour, Brahim, Russell, Matthew R, Barber, Jill, Rostami-Hodjegan, Amin

“…Cytochrome P450 (P450) and uridine 5'-diphospho-glucuronosyltransferase (UGT) enzymes mediate a major proportion of phase I and phase II metabolism of…”
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3D correlative light and electron microscopy of cultured cells using serial blockface scanning electron microscopy by Russell, Matthew R G, Lerner, Thomas R, Burden, Jemima J, Nkwe, David O, Pelchen-Matthews, Annegret, Domart, Marie-Charlotte, Durgan, Joanne, Weston, Anne, Jones, Martin L, Peddie, Christopher J, Carzaniga, Raffaella, Florey, Oliver, Marsh, Mark, Gutierrez, Maximiliano G, Collinson, Lucy M

“…The processes of life take place in multiple dimensions, but imaging these processes in even three dimensions is challenging. Here, we describe a workflow for…”
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The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion by Sherling, Emma S, Perrin, Abigail J, Knuepfer, Ellen, Russell, Matthew R G, Collinson, Lucy M, Miller, Louis H, Blackman, Michael J

“…The malaria parasite Plasmodium falciparum invades, replicates within and destroys red blood cells in an asexual blood stage life cycle that is responsible for…”
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Discordant congenital heart defects in monochorionic twins: Risk factors and proposed pathophysiology by Imany-Shakibai, Helia, Yin, Ophelia, Russell, Matthew R, Sklansky, Mark, Satou, Gary, Afshar, Yalda

“…A six-fold increase in congenital heart defects (CHD) exists among monochorionic (MC) twins compared to singleton or dichorionic twin pregnancies. Though MC…”
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Lost in centrifugation: accounting for transporter protein losses in quantitative targeted absolute proteomics by Harwood, Matthew D, Russell, Matthew R, Neuhoff, Sibylle, Warhurst, Geoffrey, Rostami-Hodjegan, Amin

“…In drug development, considerable efforts are made to extrapolate from in vitro and preclinical findings to predict human drug disposition by using in vitro-in…”
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Experimental and Statistical Considerations to Avoid False Conclusions in Proteomics Studies Using Differential In-gel Electrophoresis by Karp, Natasha A., McCormick, Paul S., Russell, Matthew R., Lilley, Kathryn S.

“…In quantitative proteomics, the false discovery rate (FDR) can be defined as the number of false positives within statistically significant changes in…”
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Alternative Fusion Protein Strategies to Express Recalcitrant QconCAT Proteins for Quantitative Proteomics of Human Drug Metabolizing Enzymes and Transporters by Russell, Matthew R, Achour, Brahim, Mckenzie, Edward A, Lopez, Ruth, Harwood, Matthew D, Rostami-Hodjegan, Amin, Barber, Jill

“…QconCAT is a tool for quantitative proteomics, consisting of an artificial protein, expressed from an artificial gene, made up of a concatenated string of…”
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Depletion of TSG101 forms a mammalian `Class E' compartment: a multicisternal early endosome with multiple sorting defects by Doyotte, Aurelie, Russell, Matthew R. G, Hopkins, Colin R, Woodman, Philip G

“…The early endosome comprises morphologically distinct regions specialised in sorting cargo receptors. A central question is whether receptors move through a…”
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The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress by Perrin, Abigail J, Collins, Christine R, Russell, Matthew R G, Collinson, Lucy M, Baker, David A, Blackman, Michael J

“…Apicomplexa are obligate intracellular parasites that actively invade, replicate within, and egress from host cells. The parasite actinomyosin-based molecular…”
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Tonoplast-localized Abc2 Transporter Mediates Phytochelatin Accumulation in Vacuoles and Confers Cadmium Tolerance by Mendoza-Cózatl, David G., Zhai, Zhiyang, Jobe, Timothy O., Akmakjian, Garo Z., Song, Won-Yong, Limbo, Oliver, Russell, Matthew R., Kozlovskyy, Volodymyr I., Martinoia, Enrico, Vatamaniuk, Olena K., Russell, Paul, Schroeder, Julian I.

“…Phytochelatins mediate tolerance to heavy metals in plants and some fungi by sequestering phytochelatin-metal complexes into vacuoles. To date, only…”
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Class E compartments form in response to ESCRT dysfunction in yeast due to hyperactivity of the Vps21 Rab GTPase by Russell, Matthew R G, Shideler, Tess, Nickerson, Daniel P, West, Matt, Odorizzi, Greg

“…The endosomal sorting complexes required for transport (ESCRTs) mediate the budding of intralumenal vesicles (ILVs) at late endosomes. ESCRT dysfunction causes…”
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Distinct Requirements of Adenovirus E1b55K Protein for Degradation of Cellular Substrates by Schwartz, Rachel A, Lakdawala, Seema S, Eshleman, Heather D, Russell, Matthew R, Carson, Christian T, Weitzman, Matthew D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A concentric circle model of multivesicular body cargo sorting by Nickerson, Daniel P, Russell, Matthew R G, Odorizzi, Greg

“…Targeting of ubiquitylated transmembrane proteins into luminal vesicles of endosomal multivesicular bodies (MVBs) depends on their recognition by endosomal…”
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Termination of Isoform‐Selective Vps21/Rab5 Signaling at Endolysosomal Organelles by Msb3/Gyp3 by Nickerson, Daniel P., Russell, Matthew R. G., Lo, Shing‐Yeng, Chapin, Hannah C., Milnes, Joshua M., Merz, Alexey J.

“…Traffic through endosomes and lysosomes is controlled by small G‐proteins of the Rab5 and Rab7 families. Like humans, Saccharomyces cerevisiae has three Rab5s…”
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Initial experience with transcatheter pacemaker implantation for adults with congenital heart disease by Russell, Matthew R, Galloti, Roberto, Moore, Jeremy P

“…Background Transvenous pacemaker systems have significant advantages over epicardial systems in patients with congenital heart disease (CHD). Frequently…”
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Mycobacterium tuberculosis replicates within necrotic human macrophages by Lerner, Thomas R, Borel, Sophie, Greenwood, Daniel J, Repnik, Urska, Russell, Matthew R G, Herbst, Susanne, Jones, Martin L, Collinson, Lucy M, Griffiths, Gareth, Gutierrez, Maximiliano G

“…modulation of macrophage cell death is a well-documented phenomenon, but its role during bacterial replication is less characterized. In this study, we…”
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COVID-19 in a pediatric heart transplant recipient: Emergence of donor-specific antibodies by Russell, Matthew R., Halnon, Nancy J., Alejos, Juan C., Salem, Morris M., Reardon, Leigh C.

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Characterization of CYP2B6 K262R allelic variants by quantitative allele-specific proteomics using a QconCAT standard by Barber, Jill, Russell, Matthew R., Rostami-Hodjegan, Amin, Achour, Brahim

“…[Display omitted] •Development of QconCAT proteomic assay to characterize CYP2B6 K262R polymorphism.•Simultaneous phenotype determination and quantification of…”
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Lymphatic endothelial cells are a replicative niche for Mycobacterium tuberculosis by Lerner, Thomas R, de Souza Carvalho-Wodarz, Cristiane, Repnik, Urska, Russell, Matthew R G, Borel, Sophie, Diedrich, Collin R, Rohde, Manfred, Wainwright, Helen, Collinson, Lucy M, Wilkinson, Robert J, Griffiths, Gareth, Gutierrez, Maximiliano G

“…In extrapulmonary tuberculosis, the most common site of infection is within the lymphatic system, and there is growing recognition that lymphatic endothelial…”
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