Search Results - "Russell, J H"

Genetic and epigenetic fine mapping of causal autoimmune disease variants by Farh, Kyle Kai-How, Marson, Alexander, Zhu, Jiang, Kleinewietfeld, Markus, Housley, William J., Beik, Samantha, Shoresh, Noam, Whitton, Holly, Ryan, Russell J. H., Shishkin, Alexander A., Hatan, Meital, Carrasco-Alfonso, Marlene J., Mayer, Dita, Luckey, C. John, Patsopoulos, Nikolaos A., De Jager, Philip L., Kuchroo, Vijay K., Epstein, Charles B., Daly, Mark J., Hafler, David A., Bernstein, Bradley E.

“…Genome-wide association studies have identified loci underlying human diseases, but the causal nucleotide changes and mechanisms remain largely unknown. Here…”
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Origins of tumor-associated macrophages and neutrophils by Cortez-Retamozo, Virna, Etzrodt, Martin, Newton, Andita, Rauch, Philipp J, Chudnovskiy, Aleksey, Berger, Cedric, Ryan, Russell J. H, Iwamoto, Yoshiko, Marinelli, Brett, Gorbatov, Rostic, Forghani, Reza, Novobrantseva, Tatiana I, Koteliansky, Victor, Figueiredo, Jose-Luiz, Chen, John W, Anderson, Daniel G, Nahrendorf, Matthias, Swirski, Filip K, Weissleder, Ralph, Pittet, Mikael J

“…Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) can control cancer growth and exist in almost all solid neoplasms. The cells are…”
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Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain by Shukla, Shirish, Ying, Weijiang, Gray, Felicia, Yao, Yiwu, Simes, Miranda L., Zhao, Qingjie, Miao, Hongzhi, Cho, Hyo Je, González-Alonso, Paula, Winkler, Alyssa, Lund, George, Purohit, Trupta, Kim, EunGi, Zhang, Xiaotian, Ray, Joshua M., He, Shihan, Nikolaidis, Caroline, Ndoj, Juliano, Wang, Jingya, Jaremko, Łukasz, Jaremko, Mariusz, Ryan, Russell J. H., Guzman, Monica L., Grembecka, Jolanta, Cierpicki, Tomasz

“…Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the…”
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An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma by Drier, Yotam, Cotton, Matthew J, Williamson, Kaylyn E, Gillespie, Shawn M, Ryan, Russell J H, Kluk, Michael J, Carey, Christopher D, Rodig, Scott J, Sholl, Lynette M, Afrogheh, Amir H, Faquin, William C, Queimado, Lurdes, Qi, Jun, Wick, Michael J, El-Naggar, Adel K, Bradner, James E, Moskaluk, Christopher A, Aster, Jon C, Knoechel, Birgit, Bernstein, Bradley E

“…Bradley Bernstein, Birgit Knoechel and colleagues identify super-enhancer translocations that drive overexpression of MYB in adenoid cystic carcinoma (ACC)…”
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EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas by Ryan, Russell J H, Nitta, Mai, Borger, Darrell, Zukerberg, Lawrence R, Ferry, Judith A, Harris, Nancy Lee, Iafrate, A John, Bernstein, Bradley E, Sohani, Aliyah R, Le, Long Phi

“…Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and…”
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A Global Plate Model Including Lithospheric Deformation Along Major Rifts and Orogens Since the Triassic by Müller, R. Dietmar, Zahirovic, Sabin, Williams, Simon E., Cannon, John, Seton, Maria, Bower, Dan J., Tetley, Michael G., Heine, Christian, Le Breton, Eline, Liu, Shaofeng, Russell, Samuel H. J., Yang, Ting, Leonard, Jonathon, Gurnis, Michael

“…Global deep‐time plate motion models have traditionally followed a classical rigid plate approach, even though plate deformation is known to be significant…”
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Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization by Huang, Guochang, Kaufman, Andrew J, Ryan, Russell J H, Romin, Yevgeniy, Huryn, Laryssa, Bains, Sarina, Manova-Todorova, Katia, Morris, Patricia L, Hunnicutt, Gary R, Adelman, Carrie A, Petrini, John H J, Ramanathan, Y, Singh, Bhuvanesh

“…Squamous cell carcinoma-related oncogene (SCCRO, also known as DCUN1D1) is a component of the E3 for neddylation. As such, DCUN1D1 regulates the neddylation of…”
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Genetic Events That Shape the Cancer Epigenome by Ryan, Russell J. H., Bernstein, Bradley E.

“…Mutations in chromatin-related genes in human tumors support a role for epigenetic mechanisms in driving cancer. Since the discovery of the first recurrent…”
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Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue With Amyloid Deposition: A Clinicopathologic Case Series by RYAN, Russell J. H, MARK SLOAN, J, BERNARD COLLINS, A, MANSOURI, Jaleh, RAJE, Noopur S, ZUKERBERG, Lawrence R, FERRY, Judith A

“…Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma is a mature B-cell neoplasm that typically follows an indolent clinical…”
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Use of Hyaluronic Acid Filler in Patients with Secondary Cleft Lip Deformity by Rivers, C. M., Skimming, C., Chong, D., Drake, D., Russell, C. J. H., Devlin, M. F.

“…When considering the management of asymmetry, volume deficiency, scarring and vermillion notching following cleft lip repair, surgical techniques are commonly…”
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A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression by Gupta, Rajat M., Hadaya, Joseph, Trehan, Aditi, Zekavat, Seyedeh M., Roselli, Carolina, Klarin, Derek, Emdin, Connor A., Hilvering, Catharina R.E., Bianchi, Valerio, Mueller, Christian, Khera, Amit V., Ryan, Russell J.H., Engreitz, Jesse M., Issner, Robbyn, Shoresh, Noam, Epstein, Charles B., de Laat, Wouter, Brown, Jonathan D., Schnabel, Renate B., Bernstein, Bradley E., Kathiresan, Sekar

“…Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine…”
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Investigating the Impact of Patient-Related Factors on Speech Outcomes at 5 Years of Age in Children With a Cleft Palate by Butterworth, Sophie, Fitzsimons, Kate J, Medina, Jibby, Britton, Lorraine, Van Eeden, Stephanie, Wahedally, Hussain, Park, Min Hae, van Der Muelen, Jan, Russell, Craig J H

“…Objective To investigate the relationship between patient-related factors (sex, cleft type, cleft extent, and Robin Sequence [RS]) and speech outcome at 5…”
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Mature T Cells of Autoimmune lpr/lpr Mice have a Defect in Antigen- Stimulated Suicide by Russell, John H., Rush, Brian, Weaver, Casey, Wang, Ruduan

“…Antigen receptor-stimulated cell death of developing, immature T cells plays an important role in shaping the repertoire of antigens to which mature T cells…”
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A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes by van Galen, Peter, Viny, Aaron D., Ram, Oren, Ryan, Russell J.H., Cotton, Matthew J., Donohue, Laura, Sievers, Cem, Drier, Yotam, Liau, Brian B., Gillespie, Shawn M., Carroll, Kaitlin M., Cross, Michael B., Levine, Ross L., Bernstein, Bradley E.

“…Genome-wide profiling of histone modifications can provide systematic insight into the regulatory elements and programs engaged in a given cell type. However,…”
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The Diverse Roles of ETV6 Alterations in B-Lymphoblastic Leukemia and Other Hematopoietic Cancers by Monovich, Alexander C, Gurumurthy, Aishwarya, Ryan, Russell J H

“…Genetic alterations of the repressive ETS family transcription factor gene ETV6 are recurrent in several categories of hematopoietic malignancy, including…”
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Cdc73 protects Notch-induced T-cell leukemia cells from DNA damage and mitochondrial stress by Melnick, Ashley F, Mullin, Carea, Lin, Karena, McCarter, Anna C, Liang, Shannon, Liu, Yiran E, Wang, Qing, Jerome, Nicole A, Choe, Elizabeth, Kunnath, Nicholas, Bodanapu, Geethika, Akter, Fatema, Magnuson, Brian, Kumar, Surinder, Lombard, David B, Muntean, Andrew G, Ljungman, Mats, Sekiguchi, JoAnn, Ryan, Russell J H, Chiang, Mark Y

“…Activated Notch signaling is highly prevalent in T-cell acute lymphoblastic leukemia (T-ALL), but pan-Notch inhibitors showed excessive toxicity in clinical…”
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EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma by Apfelbaum, April A, Wu, Feinan, Hawkins, Allegra G, Magnuson, Brian, Jiménez, Jennifer A, Taylor, Sean D, Wrenn, Emma D, Waltner, Olivia, Pfaltzgraff, Elise R, Song, Jane Y, Hall, Cody, Wellik, Deneen M, Ljungman, Mats, Furlan, Scott N, Ryan, Russell J H, Sarthy, Jay F, Lawlor, Elizabeth R

“…Propagation of Ewing sarcoma requires precise regulation of EWS::FLI1 transcriptional activity. Determining the mechanisms of fusion regulation will advance…”
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Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma by Ryan, Russell J H, Drier, Yotam, Whitton, Holly, Cotton, M Joel, Kaur, Jasleen, Issner, Robbyn, Gillespie, Shawn, Epstein, Charles B, Nardi, Valentina, Sohani, Aliyah R, Hochberg, Ephraim P, Bernstein, Bradley E

“…B-cell lymphomas frequently contain genomic rearrangements that lead to oncogene activation by heterologous distal regulatory elements. We used a novel…”
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Complications of ventilation tube insertion in children with and without cleft palate: a nested case-control comparison by Smillie, Ian, Robertson, Sophie, Yule, Anna, Wynne, David M, Russell, Craig J H

“…Optimizing hearing in patients with cleft lip and/or palate (CLP) by early recognition and management of otitis media with effusion is essential for speech…”
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Preliminary results from five generations of a western redcedar (Thuja plicata) selection study with self-mating by Russell, J. H, Ferguson, D. C

“…A western redcedar selection study with self-mating was initiated using an accelerated breeding cycle, such that five generations were completed in 10 years…”
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