Search Results - "Russell, Georgina M"

MECHANISMS IN ENDOCRINOLOGY: Does circadian and ultradian glucocorticoid exposure affect the brain? by Kalafatakis, Konstantinos, Russell, Georgina M, Lightman, Stafford L

“…Glucocorticoids are a class of systematically secreted hormones, vital for mammalian life, which are intensively investigated for more than 80 years. They…”
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Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy by Henley, David E., Russell, Georgina M., Douthwaite, Jennie A., Wood, Susan A., Buchanan, Fiona, Gibson, Rosemary, Woltersdorf, Wolfram W., Catterall, James R., Lightman, Stafford L.

“…Context: Obstructive sleep apnea (OSA) is a common condition with significant cardiovascular and metabolic comorbidity. We hypothesized that these may result…”
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The significance of glucocorticoid pulsatility by Lightman, Stafford L., Wiles, Crispin C., Atkinson, Helen C., Henley, David E., Russell, Georgina M., Leendertz, Jack A., McKenna, Mervyn A., Spiga, Francesca, Wood, Susan A., Conway-Campbell, Becky L.

“…Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately…”
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Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males by Russell, Georgina M, Henley, David E, Leendertz, Jack, Douthwaite, Jennie A, Wood, Susan A, Stevens, Adam, Woltersdorf, Wolfram W, Peeters, Bernard W M M, Ruigt, Ge S F, White, Anne, Veldhuis, Johannes D, Lightman, Stafford L

“…A complex dynamic ultradian rhythm underlies the hypothalamic-pituitary-adrenal (HPA) circadian rhythm. We have investigated in normal human male subjects the…”
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Remote Evaluation of Sleep and Circadian Rhythms in Older Adults With Mild Cognitive Impairment and Dementia: Protocol for a Feasibility and Acceptability Mixed Methods Study by Gabb, Victoria Grace, Blackman, Jonathan, Morrison, Hamish Duncan, Biswas, Bijetri, Li, Haoxuan, Turner, Nicholas, Russell, Georgina M, Greenwood, Rosemary, Jolly, Amy, Trender, William, Hampshire, Adam, Whone, Alan, Coulthard, Elizabeth

“…Sleep disturbances are a potentially modifiable risk factor for neurodegenerative dementia secondary to Alzheimer disease (AD) and Lewy body disease (LBD)…”
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Modelling Hydrocortisone Pharmacokinetics on a Subcutaneous Pulsatile Infusion Replacement Strategy in Patients with Adrenocortical Insufficiency by Violaris, Ioannis G., Kalafatakis, Konstantinos, Zavala, Eder, Tsoulos, Ioannis G., Lampros, Theodoros, Lightman, Stafford L., Tsipouras, Markos G., Giannakeas, Nikolaos, Tzallas, Alexandros, Russell, Georgina M.

“…In the context of glucocorticoid (GC) therapeutics, recent studies have utilised a subcutaneous hydrocortisone (HC) infusion pump programmed to deliver…”
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Transcriptional and cell type profiles of cortical brain regions showing ultradian cortisol rhythm dependent responses to emotional face stimulation by Habets, Philippe C., Kalafatakis, Konstantinos, Dzyubachyk, Oleh, van der Werff, Steven J.A., Keo, Arlin, Thakrar, Jamini, Mahfouz, Ahmed, Pereira, Alberto M., Russell, Georgina M., Lightman, Stafford L., Meijer, Onno C.

“…The characteristic endogenous circadian rhythm of plasma glucocorticoid concentrations is made up from an underlying ultradian pulsatile secretory pattern…”
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Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics by Kalafatakis, Konstantinos, Russell, Georgina M, Zarros, Apostolos, Lightman, Stafford L

“…Glucocorticoids mediate plethora of actions throughout the human body. Within the brain, they modulate aspects of immune system and neuroinflammatory…”
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Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery by Gibbison, Ben, Spiga, Francesca, Walker, Jamie J, Russell, Georgina M, Stevenson, Kirsty, Kershaw, Yvonne, Zhao, Zidong, Henley, David, Angelini, Gianni D, Lightman, Stafford L

“…OBJECTIVES:To characterize the dynamics of the pituitary-adrenal interaction during the course of coronary artery bypass grafting both on and off pump. Since…”
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Continuous Free Cortisol Profiles in Healthy Men - Validation of Microdialysis Method by Bhake, R, Russell, G M, Kershaw, Y, Stevens, K, Zaccardi, F, Warburton, V E C, Linthorst, AC E, Lightman, S L

“…CONTEXTIn humans, approximately 95% of circulating cortisol is bound to corticosteroid-binding globulin and albumin. It is only the free fraction that is…”
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Glucocorticoid ultradian rhythmicity differentially regulates mood and resting state networks in the human brain: A randomised controlled clinical trial by Kalafatakis, Konstantinos, Russell, Georgina M., Ferguson, Stuart G., Grabski, Meryem, Harmer, Catherine J., Munafò, Marcus R., Marchant, Nicola, Wilson, Aileen, Brooks, Jonathan C., Thakrar, Jamini, Murphy, Patrick, Thai, Ngoc J., Lightman, Stafford L.

“…Adrenal glucocorticoid secretion into the systematic circulation is characterised by a complex rhythm, composed of the diurnal variation, formed by changes in…”
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Utilization of the allen gene expression atlas to gain further insight into glucocorticoid physiology in the adult mouse brain by Kalafatakis, Konstantinos, Giannakeas, Nikolaos, Lightman, Stafford L., Charalampopoulos, Ioannis, Russell, Georgina M., Tsipouras, Markos, Tzallas, Alexandros

“…The neuroanatomic variation of the genomic expression of 25 genes involved in the regulation of glucocorticoid dynamics has been highlighted across 96 regions…”
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Subcutaneous pulsatile glucocorticoid replacement therapy by Russell, Georgina M., Durant, Claire, Ataya, Alia, Papastathi, Chrysoula, Bhake, Ragini, Woltersdorf, Wolfram, Lightman, Stafford

“…Summary The glucocorticoid hormone cortisol is released in pulses resulting in a complex and dynamic ultradian rhythm of plasma cortisol that underlies the…”
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Can side effects of steroid treatments be minimized by the temporal aspects of delivery method? by Russell, Georgina M, Lightman, Stafford L

“…Glucocorticoids are commonly prescribed medications associated with significant mortality and morbidity, even when used at physiological dosages. The…”
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Effects of the pattern of glucocorticoid replacement on neural processing, emotional reactivity and well-being in healthy male individuals: study protocol for a randomised controlled trial by Kalafatakis, Konstantinos, Russell, Georgina M, Harmer, Catherine J, Munafo, Marcus R, Marchant, Nicky, Wilson, Aileen, Brooks, Jonathan C W, Thai, Ngoc J, Ferguson, Stuart G, Stevenson, Kirsty, Durant, Claire, Schmidt, Kristin, Lightman, Stafford L

“…Deviation from the physiological glucocorticoid dynamics (circadian and underlying ultradian rhythmicity) is a common characteristic of various…”
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Continuous Free Cortisol Profiles in Healthy Men by Bhake, Ragini, Russell, Georgina M, Kershaw, Yvonne, Stevens, Kara, Zaccardi, Francesco, Warburton, Viktoria E C, Linthorst, Astrid C E, Lightman, Stafford L

“…In humans, approximately 95% of circulating cortisol is bound to corticosteroid-binding globulin and albumin. It is only the free fraction that is biologically…”
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SAT296 Ambulatory 24-hour Tissue Microdialysis Of Cortisol And Metabolites, A Tool For Precision Management In Addison’s Disease by Botusan, Ileana, Berinder, Katarina, Methlie, Paal, Upton, Thomas, Zavala, Eder, Simunkova, Katerina, Vassiliadi, Dimitra Argyro, Marinelli, Isabella, Russell, Georgina M, Grytaas, Marianne Aardal, Tsagarakis, Stylianos, Lightman, Stafford Louis, Husebye, Eystein Sverre, Kampe, Olle, Oksnes, Marianne, Bensing, Sophie

“…Abstract Disclosure: I. Botusan: None. K. Berinder: None. P. Methlie: None. T. Upton: None. E. Zavala: None. K. Simunkova: None. D.A. Vassiliadi: None. I…”
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OR30-03 High Resolution Daily Profiles Of Tissue Adrenal Steroids By Portable Automated Collection by Upton, Thomas, Zavala, Eder, Methlie, Paal, Oksnes, Marianne, Grytaas, Marianne Aardal, Simunkova, Katerina, Bensing, Sophie, Botusan, Ileana, Berinder, Katarina, Vassiliadi, Dimitra Argyro, Kampe, Olle, Tsagarakis, Stylianos, Husebye, Eystein Sverre, Russell, Georgina M, Lightman, Stafford Louis

“…Abstract Disclosure: T. Upton: None. E. Zavala: None. P. Methlie: None. M. Oksnes: None. M.A. Grytaas: None. K. Simunkova: None. S. Bensing: None. I. Botusan:…”
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OR02-03 Twenty-four-hour Tissue Microdialysis Of Aldosterone And Metabolites In Primary Aldosteronism by Aardal Grytaas, Marianne, Methlie, Paal, Marinelli, Isabella, Zavala, Eder, Øksnes, Marianne, Upton, Thomas, Simunkova, Katerina, Argyro Vassiliadi, Dimitra, Løvås, Kristian, Bensing, Sofie, Botusan, Ileana, Berinder, Katarina, Russell, Georgina M, Ueland, Grethe, Kampe, Olle, Tsagarakis, Stylianos, Louis Lightman, Stafford, Sverre Husebye, Eystein

“…Abstract Disclosure: M.A. Grytaas: None. P. Methlie: None. I. Marinelli: None. E. Zavala: None. M. Øksnes: None. T. Upton: None. K. Simunkova: None. D.A…”
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The significance of glucocorticoid pulsatility: Stress Hormone Actions in Brain, in Health and Disease. Possibilities for New Pharmacotherapies by LIGHTMAN, Stafford L, WILES, Crispin C, ATKINSON, Helen C, HENLEY, David E, RUSSELL, Georgina M, LEENDERTZ, Jack A, MCKENNA, Mervyn A, SPIGA, Francesca, WOOD, Susan A, CONWAY-CAMPBELL, Becky L

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