Search Results - "Russell, Darryl L"

Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time by Robker, Rebecca L, Hennebold, Jon D, Russell, Darryl L

“…Abstract Ovulation is the appropriately timed release of a mature, developmentally competent oocyte from the ovary into the oviduct, where fertilization…”
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Bidirectional communication between cumulus cells and the oocyte: Old hands and new players? by Russell, Darryl L., Gilchrist, Robert B., Brown, Hannah M., Thompson, Jeremy G.

“…Cumulus cell–oocyte communication is an essential feature of mammalian reproduction. Established mechanisms involve the bidirectional transfer of ions and…”
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Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors by Wu, Linda L, Russell, Darryl L, Wong, Siew L, Chen, Miaoxin, Tsai, Te-Sha, St John, Justin C, Norman, Robert J, Febbraio, Mark A, Carroll, John, Robker, Rebecca L

“…Over-nutrition in females causes altered fetal growth during pregnancy and permanently programs the metabolism of offspring; however, the temporal and…”
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Molecular mechanisms of ovulation: co-ordination through the cumulus complex by Russell, Darryl L., Robker, Rebecca L.

“…Successful ovulation requires that developmentally competent oocytes are released with appropriate timing from the ovarian follicle. Somatic cells of the…”
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Regulation of fatty acid oxidation in mouse cumulus-oocyte complexes during maturation and modulation by PPAR agonists by Dunning, Kylie R, Anastasi, Marie R, Zhang, Voueleng J, Russell, Darryl L, Robker, Rebecca L

“…Fatty acid oxidation is an important energy source for the oocyte; however, little is known about how this metabolic pathway is regulated in cumulus-oocyte…”
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High-Fat Diet Causes Lipotoxicity Responses in Cumulus–Oocyte Complexes and Decreased Fertilization Rates by Wu, Linda Lin-Yan, Dunning, Kylie R, Yang, Xing, Russell, Darryl L, Lane, Michelle, Norman, Robert J, Robker, Rebecca L

“…In obesity, accumulation of lipid in nonadipose tissues, or lipotoxicity, is associated with endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and…”
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The metalloproteinase ADAMTS1: A comprehensive review of its role in tumorigenic and metastatic pathways by Arao Tan, Izza, Ricciardelli, Carmela, Russell, Darryl L.

“…As it was first characterized in 1997, the ADAMTS (A Disintegrin and Metalloprotease with ThromboSpondin motifs) metalloprotease family has been associated…”
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Endoplasmic Reticulum (ER) Stress in Cumulus-Oocyte Complexes Impairs Pentraxin-3 Secretion, Mitochondrial Membrane Potential (ΔΨm), and Embryo Development by Wu, Linda L, Russell, Darryl L, Norman, Robert J, Robker, Rebecca L

“…Fatty acids such as palmitic acid at high levels are known to induce endoplasmic reticulum (ER) stress and lipotoxicity in numerous cell types and thereby…”
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Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary by Umehara, Takashi, Winstanley, Yasmyn E., Andreas, Eryk, Morimoto, Atsushi, Williams, Elisha J., Smith, Kirsten M., Carroll, John, Febbraio, Mark A., Shimada, Masayuki, Russell, Darryl L., Robker, Rebecca L.

“…The female ovary contains a finite number of oocytes, and their release at ovulation becomes sporadic and disordered with aging and with obesity, leading to…”
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Endocrine Disruptor Compounds-A Cause of Impaired Immune Tolerance Driving Inflammatory Disorders of Pregnancy? by Schjenken, John E, Green, Ella S, Overduin, Tenuis S, Mah, Chui Yan, Russell, Darryl L, Robertson, Sarah A

“…Endocrine disrupting compounds (EDCs) are prevalent and ubiquitous in our environment and have substantial potential to compromise human and animal health…”
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The biological role and regulation of versican levels in cancer by Ricciardelli, Carmela, Sakko, Andrew J., Ween, Miranda P., Russell, Darryl L., Horsfall, David J.

“…Increased expression of the proteoglycan, versican is strongly associated with poor outcome for many different cancers. Depending on the cancer type, versican…”
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Regulation of the ovarian inflammatory response at ovulation by nuclear progesterone receptor by Akison, Lisa K., Robertson, Sarah A., Gonzalez, Macarena B., Richards, JoAnne S., Smith, C. Wayne, Russell, Darryl L., Robker, Rebecca L.

“…Problem The nuclear progesterone receptor (PGR) transcription factor is essential for ovulation; however, the exact mechanisms by which PGR controls ovulation…”
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ADAMTS1 Promotes Adhesion to Extracellular Matrix Proteins and Predicts Prognosis in Early Stage Breast Cancer Patients by Tan, Izza A, Frewin, Kate, Ricciardelli, Carmela, Russell, Darryl L

“…Despite, several studies demonstrating pro-metastatic effects of the metalloproteinase ADAMTS1 in breast cancer, its role in facilitating the metastatic…”
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The ADAMTS1 Protease Gene Is Required for Mammary Tumor Growth and Metastasis by Ricciardelli, Carmela, Frewin, Kate M, Tan, Izza de Arao, Williams, Elizabeth D, Opeskin, Kenneth, Pritchard, Melanie A, Ingman, Wendy V, Russell, Darryl L

“…A disintegrin and metalloprotease with thrombospondin motifs protein 1 (ADAMTS1) is a protease commonly up-regulated in metastatic carcinoma. Its…”
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Development and Hormonal Regulation of the Ovarian Lymphatic Vasculature by Brown, Hannah M, Robker, Rebecca L, Russell, Darryl L

“…The lymphatic vasculature plays a number of essential physiological roles including maintaining fluid homeostasis, providing a network for the transport of…”
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Heparan Sulfate Proteoglycans Regulate Responses to Oocyte Paracrine Signals in Ovarian Follicle Morphogenesis by Watson, Laura N, Mottershead, David G, Dunning, Kylie R, Robker, Rebecca L, Gilchrist, Robert B, Russell, Darryl L

“…In the ovarian follicle, oocyte-secreted factors induce cumulus-specific genes and repress mural granulosa cell specific genes to establish these functionally…”
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Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion by Robker, Rebecca L, Watson, Laura N, Robertson, Sarah A, Dunning, Kylie R, McLaughlin, Eileen A, Russell, Darryl L

“…The STAT3 transcription factor is a pleiotropic transducer of signalling by hormones, growth factors and cytokines that has been identified in the female…”
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Formation of Hyaluronan- and Versican-rich Pericellular Matrix by Prostate Cancer Cells Promotes Cell Motility by Ricciardelli, Carmela, Russell, Darryl L., Ween, Miranda P., Mayne, Keiko, Suwiwat, Supaporn, Byers, Sharon, Marshall, Villis R., Tilley, Wayne D., Horsfall, David J.

“…Previous studies have demonstrated that high levels of hyaluronan (HA) and the chondroitin sulfate proteoglycan, versican in the peritumoral stroma are…”
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NanoFIRE: A NanoLuciferase and Fluorescent Integrated Reporter Element for Robust and Sensitive Investigation of HIF and Other Signalling Pathways by Roennfeldt, Alison E, Allen, Timothy P, Trowbridge, Brooke N, Beard, Michael R, Whitelaw, Murray L, Russell, Darryl L, Bersten, David C, Peet, Daniel J

“…The Hypoxia Inducible Factor (HIF) transcription factors are imperative for cell adaption to low oxygen conditions and development; however, they also…”
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Growth differentiation factor 9 signaling requires ERK1/2 activity in mouse granulosa and cumulus cells by Sasseville, Maxime, Ritter, Lesley J, Nguyen, Thao M, Liu, Fang, Mottershead, David G, Russell, Darryl L, Gilchrist, Robert B

“…Ovarian folliculogenesis is driven by the combined action of endocrine cues and paracrine factors. The oocyte secretes powerful mitogens, such as growth…”
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