Search Results - "Russell, Darryl"

Follicle Fitness: Key Factors for Ovarian Health and Better Contraceptive Strategies by Russell, Darryl

“…The ovarian follicle is an important endocrine organ that controls the female reproductive cycle through hypothalamic-pituitary-ovarian hormonal communication,…”
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Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time by Robker, Rebecca L, Hennebold, Jon D, Russell, Darryl L

“…Abstract Ovulation is the appropriately timed release of a mature, developmentally competent oocyte from the ovary into the oviduct, where fertilization…”
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Lipids and oocyte developmental competence: the role of fatty acids and β-oxidation by Dunning, Kylie R, Russell, Darryl L, Robker, Rebecca L

“…Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated with quality of oocyte and optimal development of a healthy embryo. Lipid…”
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Bidirectional communication between cumulus cells and the oocyte: Old hands and new players? by Russell, Darryl L., Gilchrist, Robert B., Brown, Hannah M., Thompson, Jeremy G.

“…Cumulus cell–oocyte communication is an essential feature of mammalian reproduction. Established mechanisms involve the bidirectional transfer of ions and…”
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Regulation of fatty acid oxidation in mouse cumulus-oocyte complexes during maturation and modulation by PPAR agonists by Dunning, Kylie R, Anastasi, Marie R, Zhang, Voueleng J, Russell, Darryl L, Robker, Rebecca L

“…Fatty acid oxidation is an important energy source for the oocyte; however, little is known about how this metabolic pathway is regulated in cumulus-oocyte…”
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Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors by Wu, Linda L, Russell, Darryl L, Wong, Siew L, Chen, Miaoxin, Tsai, Te-Sha, St John, Justin C, Norman, Robert J, Febbraio, Mark A, Carroll, John, Robker, Rebecca L

“…Over-nutrition in females causes altered fetal growth during pregnancy and permanently programs the metabolism of offspring; however, the temporal and…”
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Molecular mechanisms of ovulation: co-ordination through the cumulus complex by Russell, Darryl L., Robker, Rebecca L.

“…Successful ovulation requires that developmentally competent oocytes are released with appropriate timing from the ovarian follicle. Somatic cells of the…”
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High-Fat Diet Causes Lipotoxicity Responses in Cumulus–Oocyte Complexes and Decreased Fertilization Rates by Wu, Linda Lin-Yan, Dunning, Kylie R, Yang, Xing, Russell, Darryl L, Lane, Michelle, Norman, Robert J, Robker, Rebecca L

“…In obesity, accumulation of lipid in nonadipose tissues, or lipotoxicity, is associated with endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and…”
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Beta-Oxidation Is Essential for Mouse Oocyte Developmental Competence and Early Embryo Development by Dunning, Kylie R, Cashman, Kara, Russell, Darryl L, Thompson, Jeremy G, Norman, Robert J, Robker, Rebecca L

“…Oocyte and embryo metabolism are closely linked with their subsequent developmental capacity. Lipids are a potent source of cellular energy, yet little is…”
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Extracellular matrix of the cumulus-oocyte complex by Russell, Darryl L, Salustri, Antonietta

“…The mammalian oocyte is surrounded by several layers of cumulus granulosa cells that nurture the oocyte during its development and actively participate in the…”
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The metalloproteinase ADAMTS1: A comprehensive review of its role in tumorigenic and metastatic pathways by Arao Tan, Izza, Ricciardelli, Carmela, Russell, Darryl L.

“…As it was first characterized in 1997, the ADAMTS (A Disintegrin and Metalloprotease with ThromboSpondin motifs) metalloprotease family has been associated…”
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Endoplasmic Reticulum (ER) Stress in Cumulus-Oocyte Complexes Impairs Pentraxin-3 Secretion, Mitochondrial Membrane Potential (ΔΨm), and Embryo Development by Wu, Linda L, Russell, Darryl L, Norman, Robert J, Robker, Rebecca L

“…Fatty acids such as palmitic acid at high levels are known to induce endoplasmic reticulum (ER) stress and lipotoxicity in numerous cell types and thereby…”
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Female reproductive life span is extended by targeted removal of fibrotic collagen from the mouse ovary by Umehara, Takashi, Winstanley, Yasmyn E., Andreas, Eryk, Morimoto, Atsushi, Williams, Elisha J., Smith, Kirsten M., Carroll, John, Febbraio, Mark A., Shimada, Masayuki, Russell, Darryl L., Robker, Rebecca L.

“…The female ovary contains a finite number of oocytes, and their release at ovulation becomes sporadic and disordered with aging and with obesity, leading to…”
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Stem Cells, Progenitor Cells, and Lineage Decisions in the Ovary by Hummitzsch, Katja, Anderson, Richard A, Wilhelm, Dagmar, Wu, Ji, Telfer, Evelyn E, Russell, Darryl L, Robertson, Sarah A, Rodgers, Raymond J

“…Exploring stem cells in the mammalian ovary has unleashed a Pandora's box of new insights and questions. Recent evidence supports the existence of stem cells…”
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ADAMTS proteases in fertility by Russell, Darryl L., Brown, Hannah M., Dunning, Kylie R.

“…The reproductive organs are unique among adult organs in that they must undergo continual tissue remodelling as a key aspect of their normal function. The…”
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Endocrine Disruptor Compounds-A Cause of Impaired Immune Tolerance Driving Inflammatory Disorders of Pregnancy? by Schjenken, John E, Green, Ella S, Overduin, Tenuis S, Mah, Chui Yan, Russell, Darryl L, Robertson, Sarah A

“…Endocrine disrupting compounds (EDCs) are prevalent and ubiquitous in our environment and have substantial potential to compromise human and animal health…”
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The biological role and regulation of versican levels in cancer by Ricciardelli, Carmela, Sakko, Andrew J., Ween, Miranda P., Russell, Darryl L., Horsfall, David J.

“…Increased expression of the proteoglycan, versican is strongly associated with poor outcome for many different cancers. Depending on the cancer type, versican…”
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Human cumulus cell gene expression as a biomarker of pregnancy outcome after single embryo transfer by Gebhardt, Kathryn Michelle, Ph.D, Feil, Deanne Kate, Ph.D, Dunning, Kylie Renee, Ph.D, Lane, Michelle, Ph.D, Russell, Darryl Lyndon, Ph.D

“…Objective To identify the cumulus cell gene expression associated with oocyte developmental competence, specifically live birth, after single ET (SET) assisted…”
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Granulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging by Morimoto, Atsushi, Rose, Ryan D, Smith, Kirsten M, Dinh, Doan T, Umehara, Takashi, Winstanley, Yasmyn E, Shibahara, Hiroaki, Russell, Darryl L, Robker, Rebecca L

“…Abstract STUDY QUESTION Is oocyte developmental competence associated with changes in granulosa cell (GC) metabolism? SUMMARY ANSWER GC metabolism is regulated…”
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The Ovarian Antral Follicle: Living on the Edge of Hypoxia or Not? by Thompson, Jeremy G, Brown, Hannah M, Kind, Karen L, Russell, Darryl L

“…Oocytes within antral follicles are thought to have restricted access to O2, as follicle vascularity is not adjacent and both granulosa and cumulus cells are…”
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