Search Results - "Russ, Brendan E."

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation by Russ, Brendan E., Olshanksy, Moshe, Smallwood, Heather S., Li, Jasmine, Denton, Alice E., Prier, Julia E., Stock, Angus T., Croom, Hayley A., Cullen, Jolie G., Nguyen, Michelle L.T., Rowe, Stephanie, Olson, Matthew R., Finkelstein, David B., Kelso, Anne, Thomas, Paul G., Speed, Terry P., Rao, Sudha, Turner, Stephen J.

“…The molecular mechanisms that regulate the rapid transcriptional changes that occur during cytotoxic T lymphocyte (CTL) proliferation and differentiation in…”
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Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8+ T cells by Denton, Alice E, Russ, Brendan E, Doherty, Peter C, Rao, Sudha, Turner, Stephen J

“…Although the simultaneous engagement of multiple effector mechanisms is thought to characterize optimal CD8+ T-cell immunity and facilitate pathogen clearance,…”
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UL34 Deletion Restricts Human Cytomegalovirus Capsid Formation and Maturation by Turner, Declan L, Templin, Rachel M, Barugahare, Adele A, Russ, Brendan E, Turner, Stephen J, Ramm, Georg, Mathias, Rommel A

“…Over 50% of the world’s population is infected with Human Cytomegalovirus (HCMV). HCMV is responsible for serious complications in the immuno-compromised and…”
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Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function by Russ, Brendan E., Olshansky, Moshe, Li, Jasmine, Nguyen, Michelle L.T., Gearing, Linden J., Nguyen, Thi H.O., Olson, Matthew R., McQuilton, Hayley A., Nüssing, Simone, Khoury, Georges, Purcell, Damian F.J., Hertzog, Paul J., Rao, Sudha, Turner, Stephen J.

“…Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the gene regulatory mechanisms that…”
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Active maintenance of CD8+ T cell naivety through regulation of global genome architecture by Russ, Brendan E., Barugahare, Adele, Dakle, Pushkar, Tsyganov, Kirril, Quon, Sara, Yu, Bingfei, Li, Jasmine, Lee, Jason K.C., Olshansky, Moshe, He, Zhaohren, Harrison, Paul F., See, Michael, Nussing, Simone, Morey, Alison E., Udupa, Vibha A., Bennett, Taylah J., Kallies, Axel, Murre, Cornelis, Collas, Phillipe, Powell, David, Goldrath, Ananda W., Turner, Stephen J.

“…The differentiation of naive CD8+ T lymphocytes into cytotoxic effector and memory CTL results in large-scale changes in transcriptional and phenotypic…”
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Glucocorticoid-induced leucine zipper (GILZ) inhibits B cell activation in systemic lupus erythematosus by Jones, Sarah A, Toh, Andrew E J, Odobasic, Dragana, Oudin, Marie-Anne Virginie, Cheng, Qiang, Lee, Jacinta P W, White, Stefan J, Russ, Brendan E, Infantino, Simona, Light, Amanda, Tarlinton, David M, Harris, James, Morand, Eric F

“…Systemic lupus erythematosus (SLE) is a serious multisystem autoimmune disease, mediated by disrupted B cell quiescence and typically treated with…”
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UL49 is an essential subunit of the viral pre-initiation complex that regulates human cytomegalovirus gene transcription by Turner, Declan L., Fritzlar, Svenja, Sadeghipour, Sara, Barugahare, Adele A., Russ, Brendan E., Turner, Stephen J., Mathias, Rommel A.

“…More than half the world’s population is infected with human cytomegalovirus (HCMV), causing congenital birth defects and impacting the immuno-compromised…”
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Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation by Russ, Brendan E., Olshanksy, Moshe, Smallwood, Heather S., Li, Jasmine, Denton, Alice E., Prier, Julia E., Stock, Angus T., Croom, Hayley A., Cullen, Jolie G., Nguyen, Michelle L.T., Rowe, Stephanie, Olson, Matthew R., Finkelstein, David B., Kelso, Anne, Thomas, Paul G., Speed, Terry P., Rao, Sudha, Turner, Stephen J.

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Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells by Bachem, Annabell, Makhlouf, Christina, Binger, Katrina J., de Souza, David P., Tull, Deidra, Hochheiser, Katharina, Whitney, Paul G., Fernandez-Ruiz, Daniel, Dähling, Sabrina, Kastenmüller, Wolfgang, Jönsson, Johanna, Gressier, Elise, Lew, Andrew M., Perdomo, Carolina, Kupz, Andreas, Figgett, William, Mackay, Fabienne, Oleshansky, Moshe, Russ, Brendan E., Parish, Ian A., Kallies, Axel, McConville, Malcolm J., Turner, Stephen J., Gebhardt, Thomas, Bedoui, Sammy

“…Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and function. Here, we examined the…”
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A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage by Koay, Hui-Fern, Gherardin, Nicholas A, Enders, Anselm, Loh, Liyen, Mackay, Laura K, Almeida, Catarina F, Russ, Brendan E, Nold-Petry, Claudia A, Nold, Marcel F, Bedoui, Sammy, Chen, Zhenjun, Corbett, Alexandra J, Eckle, Sidonia B G, Meehan, Bronwyn, d'Udekem, Yves, Konstantinov, Igor E, Lappas, Martha, Liu, Ligong, Goodnow, Chris C, Fairlie, David P, Rossjohn, Jamie, Chong, Mark M, Kedzierska, Katherine, Berzins, Stuart P, Belz, Gabrielle T, McCluskey, James, Uldrich, Adam P, Godfrey, Dale I, Pellicci, Daniel G

“…Godfrey, Pellicci and colleagues define the developmental stages and checkpoints for the development of mucosal-associated invariant T cells in humans and…”
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Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells by Quinn, Kylie M., Fox, Annette, Harland, Kim L., Russ, Brendan E., Li, Jasmine, Nguyen, Thi H.O., Loh, Liyen, Olshanksy, Moshe, Naeem, Haroon, Tsyganov, Kirill, Wiede, Florian, Webster, Rosela, Blyth, Chantelle, Sng, Xavier Y.X., Tiganis, Tony, Powell, David, Doherty, Peter C., Turner, Stephen J., Kedzierska, Katherine, La Gruta, Nicole L.

“…Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct effects on naive CD8+ T cells to reduce intrinsic functionality, but…”
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Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection by Russ, Brendan E, Denton, Alice E, Hatton, Lauren, Croom, Hayley, Olson, Matthew R, Turner, Stephen J

“…A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and…”
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CD4⁺ T help promotes influenza virus-specific CD8⁺ T cell memory by limiting metabolic dysfunction by Cullen, Jolie G., McQuilten, Hayley A., Quinn, Kylie M., Olshansky, Moshe, Russ, Brendan E., Morey, Alison, Wei, Sanna, Prier, Julia E., La Gruta, Nicole L., Doherty, Peter C., Turner, Stephen J.

“…There is continued interest in developing novel vaccine strategies that induce establish optimal CD8⁺ cytotoxic T lymphocyte (CTL) memory for pathogens like…”
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Can T cells be too exhausted to fight back? by Turner, Stephen J., Russ, Brendan E.

“…The transcriptional network becomes less malleable in persistently activated T cells When T cells are persistently activated by antigen, such as during chronic…”
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DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells by Quon, Sara, Yu, Bingfei, Russ, Brendan E., Tsyganov, Kirill, Nguyen, Hongtuyet, Toma, Clara, Heeg, Maximilian, Hocker, James D., Milner, J. Justin, Crotty, Shane, Pipkin, Matthew E., Turner, Stephen J., Goldrath, Ananda W.

“…Although the importance of genome organization for transcriptional regulation of cell-fate decisions and function is clear, the changes in chromatin…”
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GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation by Jones, Sarah A, Perera, Diluptha N, Fan, Huapeng, Russ, Brendan E, Harris, James, Morand, Eric F

“…Abstract Patients with inflammatory autoimmune diseases are routinely treated with synthetic glucocorticoids to suppress immunopathology. A crucial outcome of…”
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GILZ regulates type I interferon release and sequesters STAT1 by Nataraja, Champa, Flynn, Jacqueline, Dankers, Wendy, Northcott, Melissa, Zhu, Wendy, Sherlock, Rochelle, Bennett, Taylah J., Russ, Brendan E., Miceli, Iolanda, Pervin, Mehnaz, D'Cruz, Akshay, Harris, James, Morand, Eric F., Jones, Sarah A.

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KDM6B-dependent chromatin remodeling underpins effective virus-specific CD8+ T cell differentiation by Li, Jasmine, Hardy, Kristine, Olshansky, Moshe, Barugahare, Adele, Gearing, Linden J., Prier, Julia E., Sng, Xavier Y.X., Nguyen, Michelle Ly Thai, Piovesan, Dana, Russ, Brendan E., La Gruta, Nicole L., Hertzog, Paul J., Rao, Sudha, Turner, Stephen J.

“…Naive CD8+ T cell activation results in an autonomous program of cellular proliferation and differentiation. However, the mechanisms that underpin this process…”
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SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells by Nüssing, Simone, Miosge, Lisa A, Lee, Kah, Olshansky, Moshe, Barugahare, Adele, Roots, Carla M, Sontani, Yovina, Day, E Bridie, Koutsakos, Marios, Kedzierska, Katherine, Goodnow, Christopher C, Russ, Brendan E, Daley, Stephen R, Turner, Stephen J

“…Special AT‐binding protein 1 (SATB1) is a chromatin‐binding protein that has been shown to be a key regulator of T‐cell development and CD4+ T‐cell fate…”
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Rare variants in non-coding regulatory regions of the genome that affect gene expression in systemic lupus erythematosus by Jones, Sarah A., Cantsilieris, Stuart, Fan, Huapeng, Cheng, Qiang, Russ, Brendan E., Tucker, Elena J., Harris, James, Rudloff, Ina, Nold, Marcel, Northcott, Melissa, Dankers, Wendy, Toh, Andrew E. J., White, Stefan J., Morand, Eric F.

“…Personalized medicine approaches are increasingly sought for diseases with a heritable component. Systemic lupus erythematosus (SLE) is the prototypic…”
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