Search Results - "Rusin, Marek"

The Wheel of p53 Helps to Drive the Immune System by Łasut-Szyszka, Barbara, Rusin, Marek

“…The p53 tumor suppressor protein is best known as an inhibitor of the cell cycle and an inducer of apoptosis. Unexpectedly, these functions of p53 are not…”
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Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells by Janus, Patryk, Toma-Jonik, Agnieszka, Vydra, Natalia, Mrowiec, Katarzyna, Korfanty, Joanna, Chadalski, Marek, Widłak, Piotr, Dudek, Karolina, Paszek, Anna, Rusin, Marek, Polańska, Joanna, Widłak, Wiesława

“…Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat…”
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Mesenchymal stromal cells as carriers of IL-12 reduce primary and metastatic tumors of murine melanoma by Kułach, Natalia, Pilny, Ewelina, Cichoń, Tomasz, Czapla, Justyna, Jarosz-Biej, Magdalena, Rusin, Marek, Drzyzga, Alina, Matuszczak, Sybilla, Szala, Stanisław, Smolarczyk, Ryszard

“…Due to immunosuppressive properties and confirmed tropism towards cancer cells mesenchymal stromal cells (MSC) have been used in many trials. In our study we…”
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Antitumor effect of anti-vascular therapy with STING agonist depends on the tumor microenvironment context by Czapla, Justyna, Drzyzga, Alina, Matuszczak, Sybilla, Cichoń, Tomasz, Rusin, Marek, Jarosz-Biej, Magdalena, Pilny, Ewelina, Smolarczyk, Ryszard

“…IntroductionTargeting tumor vasculature is an efficient weapon to fight against cancer; however, activation of alternative pathways to rebuild the disrupted…”
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Transcriptome Analysis of Cells Exposed to Actinomycin D and Nutlin-3a Reveals New Candidate p53-Target Genes and Indicates That CHIR-98014 Is an Important Inhibitor of p53 Activity by Łasut-Szyszka, Barbara, Małachowska, Beata, Gdowicz-Kłosok, Agnieszka, Krześniak, Małgorzata, Głowala-Kosińska, Magdalena, Zajkowicz, Artur, Rusin, Marek

“…Co-treatment with actinomycin D and nutlin-3a (A + N) strongly activates p53. Previously we reported that CHIR-98014 (GSK-3 kinase inhibitor), acting in cells…”
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Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D by Krześniak, Małgorzata, Zajkowicz, Artur, Matuszczyk, Iwona, Rusin, Marek

“…•Actinomycin D strongly activates the p53 pathway in the A549 lung cancer cell line.•Actinomycin D promotes phosphorylation of p53 on Ser46.•Rapamycin inhibits…”
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Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin by Zajkowicz, Artur, Gdowicz-Kłosok, Agnieszka, Krześniak, Małgorzata, Ścieglińska, Dorota, Rusin, Marek

“…The p53 tumor suppressor protein is a transcription factor activated by phosphorylation of its N-terminus. MDM2, encoded by a p53-activated gene, acts as a…”
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The Strong Activation of p53 Tumor Suppressor Drives the Synthesis of the Enigmatic Isoform of DUSP13 Protein by Krześniak, Małgorzata, Łasut-Szyszka, Barbara, Będzińska, Agnieszka, Gdowicz-Kłosok, Agnieszka, Rusin, Marek

“…The p53 tumor suppressor protein activates various sets of genes depending on its covalent modifications, which are controlled by the nature and intensity of…”
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Genome of Bacteriophage P1 by ŁOBOCKA, Malgorzata B, ROSE, Debra J, PLUNKETT, Guy III, RUSIN, Marek, SAMOJEDNY, Arkadiusz, LEHNHERR, Hansjörg, YARMOLINSKY, Michael B, BLATTNER, Frederick R

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genetic polymorphisms in DNA repair genes and risk of lung cancer by Butkiewicz, Dorota, Rusin, Marek, Enewold, Lindsey, Shields, Peter G., Chorazy, Mieczyslaw, Harris, Curtis C.

“…Polymorphisms in DNA repair genes may be associated with differences in the repair efficiency of DNA damage and may influence an individual's risk of lung…”
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The p53 protein - not only the guardian of the genome by Rusin, Marek

“…The p53 tumor suppressor protein is best known as an activator of cell cycle arrest and apoptosis. Only a fraction of p53-activated genes encode proteins…”
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Transformation of the domain pattern in the development of Fagus silvatica L. cambium by Włoch, Wiesław, Popiel, Piotr, Rusin, Marek, Słowioczek, Anna

“…The domain pattern of cambium during the first year of its function in Fagus silvatica L. resembles a checkerboard. The longitudinal line along the leaf trace,…”
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Tumor suppressor p53 represses transcription of RECQ4 helicase by SENGUPTA, Sagar, SHIMAMOTO, Akira, HARRIS, Curtis C, KOSHIJI, Minori, PEDEUX, Remy, RUSIN, Marek, SPILLARE, Elisa A, JIANG CHENG SHEN, HUANG, L. Eric, LINDOR, Noralane M, FURUICHI, Yasuhiro

“…RECQ4 is a member of the RecQ helicase family, which has been implicated in the regulation of DNA replication, recombination and repair. p53 modulates the…”
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The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases by Zajkowicz, Artur, Rusin, Marek

“…► AICAR – the AMP mimetic substance activates p53 pathway. ► AICAR-induced p53 activation is blocked by different inhibitors of ATM kinase. ► AICAR-induced p53…”
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Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligand by Łasut-Szyszka, Barbara, Gdowicz-Kłosok, Agnieszka, Krześniak, Małgorzata, Głowala-Kosińska, Magdalena, Będzińska, Agnieszka, Rusin, Marek

“…The FAS ligand (FASLG) is expressed on lymphocytes, which employ it to activate death receptors on target cells. Cancer cells are generally resistant to…”
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Synergistic activation of p53 by actinomycin D and nutlin-3a is associated with the upregulation of crucial regulators and effectors of innate immunity by Krześniak, Małgorzata, Zajkowicz, Artur, Gdowicz-Kłosok, Agnieszka, Głowala-Kosińska, Magdalena, Łasut-Szyszka, Barbara, Rusin, Marek

“…Actinomycin D and nutlin-3a (A + N) activate p53, partly through induction of phosphorylation on Ser392. The death of A549 cells induced by A + N…”
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The Alzheimer's disease-associated TREM2 gene is regulated by p53 tumor suppressor protein by Zajkowicz, Artur, Gdowicz-Kłosok, Agnieszka, Krześniak, Małgorzata, Janus, Patryk, Łasut, Barbara, Rusin, Marek

“…•Strong activation of p53 is associated with upregulation of TREM2 pathway elements.•TREM2, TYROBP, SYK and BLNK can be upregulated in p53-dependent…”
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Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes by Łasut-Szyszka, Barbara, Gdowicz-Kłosok, Agnieszka, Małachowska, Beata, Krześniak, Małgorzata, Będzińska, Agnieszka, Gawin, Marta, Pietrowska, Monika, Rusin, Marek

“…Transcriptomic analyses have revealed hundreds of p53-regulated genes; however, these studies used a limited number of cell lines and p53-activating agents…”
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Activation of the atypical NF-κB pathway induced by ionizing radiation is not affected by the p53 status by Zając, Gracjana, Rusin, Marek, Łasut-Szyszka, Barbara, Puszyński, Krzysztof, Widłak, Piotr

“…DNA double-strand breaks induced by ionizing radiation can activate the atypical NF-κB pathway via ATM-mediated phosphorylation of NEMO/IKKγ. We aimed to…”
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Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1 by Rusin, Marek, Zajkowicz, Artur, Butkiewicz, Dorota

“…Resveratrol decreases cancer risk and improves health of laboratory animals. However, it can also promote genomic instability. Part of the beneficial activity…”
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