Search Results - "Rusin, Aleksandra"

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass by Phillips, Ellen, Ahmad, Naseer, Sun, Li, Iben, James, Walkey, Christopher J, Rusin, Aleksandra, Yuen, Tony, Rosen, Clifford J, Willis, Ian M, Zaidi, Mone, Johnson, Deborah L

“…MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays…”
Get full text

Synthetic genistein glycosides inhibiting EGFR phosphorylation enhance the effect of radiation in HCT 116 colon cancer cells by Gruca, Aleksandra, Krawczyk, Zdzisław, Szeja, Wiesław, Grynkiewicz, Grzegorz, Rusin, Aleksandra

“…The need to find new EGFR inhibitors for use in combination with radiotherapy in the treatment of solid tumors has drawn our attention to compounds derived…”
Get full text

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma by Jazowiecka-Rakus, Joanna, Sochanik, Aleksander, Rusin, Aleksandra, Hadryś, Agata, Fidyk, Wojciech, Villa, Nancy, Rahman, Masmudur M., Chmielik, Ewa, Franco, Lina S., McFadden, Grant

“…Oncolytic viruses can target neoplasms, triggering oncolytic and immune effects. Their delivery to melanoma lesions remains challenging. Bone-marrow-derived…”
Get full text

Synthesis and cytotoxicity of 2,3-enopyranosyl C-linked conjugates of genistein by Szeja, Wieslaw, Grynkiewicz, Grzegorz, Bieg, Tadeusz, Swierk, Piotr, Byczek, Anna, Papaj, Katarzyna, Kitel, Radosław, Rusin, Aleksandra

“…A series of glycoconjugates, derivatives of genistein containing a C-glycosylated carbohydrate moiety, were synthesized and their anticancer activity was…”
Get full text

Comparison of photodynamic efficacy of tetraarylporphyrin pegylated or encapsulated in liposomes: In vitro studies by Nawalany, Kinga, Rusin, Aleksandra, Kępczyński, Mariusz, Mikhailov, Alexei, Kramer-Marek, Gabriela, Śnietura, Mirosław, Połtowicz, Jan, Krawczyk, Zdzisław, Nowakowska, Maria

“…Two photosensitizing systems: (1) tetrakis(4-hydroxyphenyl)porphyrin ( p-THPP) encapsulated in sterically stabilized liposomes (SSL) and (2) p-THPP…”
Get full text

Tensile Tissue Stress Affects the Orientation of Cortical Microtubules in the Epidermis of Sunflower Hypocotyl by Hejnowicz, Zygmunt, Rusin, Aleksandra, Rusin, Tomasz

“…In turgid multicellular organs, it is convenient to differentiate between the two kinds of tensile forces acting in cell walls as a result of turgor pressure…”
Get full text

C-Glycosidic Genistein Conjugates and Their Antiproliferative Activity by Rusin, Aleksandra, Chrubasik, Maciej, Papaj, Katarzyna, Grynkiewicz, Grzegorz, Szeja, Wiesław

“…This paper presents our attempt to investigate scopes and the limitations of olefin cross-metathesis (CM) reaction in the synthesis of complex C-glycosides of…”
Get full text

The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis by Wang, Xianlong, Rusin, Aleksandra, Walkey, Christopher J., Lin, Justin J., Johnson, Deborah L.

“…MAF1 homolog, negative regulator of RNA polymerase III (MAF1) is a key repressor of RNA polymerase (pol) III–dependent transcription and functions as a tumor…”
Get full text

Abstract 50: 2-Deoxy-2-halo-D-glucose derivatives inhibition of glycolysis in pancreatic cancer by Zielinski, Rafal, Fokt, Izabela, Rusin, Aleksandra, Skora, Stanislaw, Priebe, Waldemar

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most hypoxic and subsequently glycolytic tumors. Thus the inhibition of glycolysis appears to be…”
Get full text

Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell by Papaj, Katarzyna, Kasprzycka, Anna, Góra, Artur, Grajoszek, Aniela, Rzepecka, Grażyna, Stojko, Jerzy, Barski, Jarosław-Jerzy, Szeja, Wiesław, Rusin, Aleksandra

“…•Genistein derivatives with a carbonyl linker show higher bioavailability than the natural isoflavone.•Changing the structure of genistein can modulate its…”
Get full text

Abstract A008: Elucidating the effects of the Alzheimer's disease associated gene BIN1 on cancer tumorigenesis by McColl, Collin, Skapura, Darlene, Echartea, Elisa, Deng, Jenny, Coarfa, Cristian, Kaochar, Salma, Simons, Brian, Rusin, Aleksandra

“…Abstract Purpose- BIN1 is in deleted in ~5% of all prostate cancer (PC) patients and interestingly is highly enriched in the Speckle-type POZ protein (SPOP)…”
Get full text

Inhibition of GATA2 in prostate cancer by a clinically available small molecule by Kaochar, Salma, Rusin, Aleksandra, Foley, Christopher, Rajapakshe, Kimal, Robertson, Matthew, Skapura, Darlene, Mason, Cammy, Berman De Ruiz, Karen, Tyryshkin, Alexey Mikhailovich, Deng, Jenny, Shin, Jin Na, Fiskus, Warren, Dong, Jianrong, Huang, Shixia, Navone, Nora M, Davis, Christel M, Ehli, Erik A, Coarfa, Cristian, Mitsiades, Nicholas

“…Castration-resistant prostate cancer (CRPC) remains highly lethal and in need of novel, actionable therapeutic targets. The pioneer factor GATA2 is a…”
Get full text

Abstract 2077: Exploring the multifaceted efficacy of de novo lipogenesis inhibitor in cancer therapy by Lowder, Dallin, Shin, Jin Na, Ruiz-Echartea, Maria E., Deng, Jenny, Rusin, Aleksandra, Skapura, Darlene, Ittmann, Michael, Kaochar, Salma

“…Abstract Cancer cells frequently exhibit altered lipid metabolism to sustain their rapid growth and proliferation.Sterol Regulatory Element-Binding Proteins…”
Get full text

Determination of flavonoids and their metabolites by chromatographic techniques by Szultka, Małgorzata, Buszewski, Bogusław, Papaj, Katarzyna, Szeja, Wiesław, Rusin, Aleksandra

“…•Biological properties and biotransformation of flavonoids and their metabolites.•Different methods for sample preparation of flavonoids and their…”
Get full text

Abstract 1927: Targeting IL-13RA2 in melanoma and pancreatic cancer by Zielinski, Rafal, Tworowska, Izabela, Skora, Stanislaw, Rusin, Aleksandra, Venugopal, Radjendirane, Jayakumar, Arumugam, Fokt, Izabela, Kang, Yaan, Fleming, Jason, Huang, Yue, Herpai, Denise, Debinski, Waldemar, Priebe, Waldemar

“…Abstract Background. Interleukin receptor alpha 1 (IL-13RA1) is a component of a heterodimeric IL-13 receptor that is shared with IL-4 and it is ubiquitously…”
Get full text

Abstract 1704: Interplay of MITF and NCOA3 in orchestrating oncogenic transcriptional network in uveal melanoma by Rusin, Aleksandra, Echartea, Maria E., Manikonda, Sai P., Skapura, Darlene G., Davis, Christel M., Ehli, Erik A., Grimm, Sandra L., Coarfa, Cristian, Kaochar, Salma

“…Abstract Uveal melanoma (UM) originates from melanocytes residing in the uveal tract of an eye. Despite effective local control, 50% of patients develop…”
Get full text

Abstract 3013: Alzheimer’s-linked gene BIN1: Unraveling its unexpected role as a tumor suppressor in prostate cancer and influence on androgen receptor signaling by McColl, Collin, Skapura, Darlene, Echartea, Elisa Ruiz, Deng, Jenny, Rusin, Aleksandra, Shin, Jinna, Tyryshkin, Alexey, Davis, Christel, Ehil, Erik, Kaochar, Salma

“…Abstract Androgen-receptor signaling inhibitors (ARSI) have been shown to significantly alter the natural history of castration-resistant PCa (CRPC)…”
Get full text

Synthetic derivatives of genistein, their properties and possible applications by Rusin, Aleksandra, Krawczyk, Zdzisław, Grynkiewicz, Grzegorz, Gogler, Agnieszka, Zawisza-Puchałka, Jadwiga, Szeja, Wiesław

“…Genistein, the principal isoflavone constituent of soybean, attracts much attention as a natural molecule with significant affinity towards targets of…”
Get full text

Abstract 4473: WP760, A new highly potent and selective agent against melanoma including BRAFi resistant melanoma by Rusin, Aleksandra, Zielinski, Rafal, Fokt, Izabela, Nguyen, Van, Skora, Stanislaw, Jayakumar, Arumugam, Priebe, Waldemar

“…Abstract Melanoma is expected to be diagnosed in 76,100 patients in the United States, and 9,710 patients are estimated to die of the disease in 2014…”
Get full text

Novel nanostructural photosensitizers for photodynamic therapy: In vitro studies by Nawalany, Kinga, Rusin, Aleksandra, Kepczynski, Mariusz, Filipczak, Piotr, Kumorek, Marta, Kozik, Bartłomiej, Weitman, Hana, Ehrenberg, Benjamin, Krawczyk, Zdzisław, Nowakowska, Maria

“…Photosensitizing properties of 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (p-THPP) functionalized by covalent attachment of one chain of poly(ethylene…”
Get full text