Search Results - "Rushmore, Thomas H."

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver by Yang, Xia, Zhang, Bin, Molony, Cliona, Chudin, Eugene, Hao, Ke, Zhu, Jun, Gaedigk, Andrea, Suver, Christine, Zhong, Hua, Leeder, J Steven, Guengerich, F Peter, Strom, Stephen C, Schuetz, Erin, Rushmore, Thomas H, Ulrich, Roger G, Slatter, J Greg, Schadt, Eric E, Kasarskis, Andrew, Lum, Pek Yee

“…Liver cytochrome P450s (P450s) play critical roles in drug metabolism, toxicology, and metabolic processes. Despite rapid progress in the understanding of…”
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Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes by Rushmore, Thomas H, Kong, A-N Tony

“…Drug or xenobiotics metabolizing enzymes (DMEs or XMEs) play central roles in the biotransformation, metabolism and/or detoxification of xenobiotics or foreign…”
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Substrate Inhibition Kinetics for Cytochrome P450-Catalyzed Reactions by Lin, Y, Lu, P, Tang, C, Mei, Q, Sandig, G, Rodrigues, A D, Rushmore, T H, Shou, M

“…Most cytochrome P450 (P450 or CYP)-catalyzed reactions are adequately described by classical Michaelis-Menten kinetic parameters (e.g., K m and V max ), which…”
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Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression by Hartley, Dylan P, Dai, Xudong, He, Yudong D, Carlini, Edward J, Wang, Bonnie, Huskey, Su-Er W, Ulrich, Roger G, Rushmore, Thomas H, Evers, Raymond, Evans, David C

“…Ligand-mediated activation of the pregnane X receptor (PXR, NR1I2) is postulated to affect both hepatic and intestinal gene expression, because of the presence…”
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STEREO- AND REGIOSELECTIVITY ACCOUNT FOR THE DIVERSITY OF DEHYDROEPIANDROSTERONE (DHEA) METABOLITES PRODUCED BY LIVER MICROSOMAL CYTOCHROMES P450 by MILLER, Kristy K, JIAN CAI, RIPP, Sharon L, PIERCE, William M, RUSHMORE, Thomas H, PROUGH, Russell A

“…The purpose of this study was to quantify the oxidative metabolism of dehydroepiandrosterone (3β-hydroxy-androst-5-ene-17-one; DHEA) by liver microsomal…”
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Mapping the genetic architecture of gene expression in human liver by Schadt, Eric E, Molony, Cliona, Chudin, Eugene, Hao, Ke, Yang, Xia, Lum, Pek Y, Kasarskis, Andrew, Zhang, Bin, Wang, Susanna, Suver, Christine, Zhu, Jun, Millstein, Joshua, Sieberts, Solveig, Lamb, John, GuhaThakurta, Debraj, Derry, Jonathan, Storey, John D, Avila-Campillo, Iliana, Kruger, Mark J, Johnson, Jason M, Rohl, Carol A, van Nas, Atila, Mehrabian, Margarete, Drake, Thomas A, Lusis, Aldons J, Smith, Ryan C, Guengerich, F Peter, Strom, Stephen C, Schuetz, Erin, Rushmore, Thomas H, Ulrich, Roger

“…Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in…”
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Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences by Davydov, Dmitri R, Davydova, Nadezhda Y, Rodgers, John T, Rushmore, Thomas H, Jones, Jeffrey P

“…Functional cross-talk among human drug-metabolizing cytochrome P450 through their association is a topic of emerging importance. Here, we studied the…”
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Selective inhibition of dog hepatic CYP2B11 and CYP3A12 by Lu, Ping, Singh, Suresh B, Carr, Brian A, Fang, Yulin, Xiang, Cathie Dong, Rushmore, Thomas H, Rodrigues, A David, Shou, Magang

“…In the present study, N-(alpha-methylbenzyl-)-1-aminobenzotriazole (MBA) and ketoconazole (KET) were identified as the inhibitors with selectivity toward dog…”
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Testosterone, 7-Benzyloxyquinoline, and 7-Benzyloxy-4-trifluoromethyl-coumarin Bind to Different Domains within the Active Site of Cytochrome P450 3A4 by Lu, P, Lin, Y, Rodrigues, A D, Rushmore, T H, Baillie, T A, Shou, M

“…Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin, marker substrates for cytochrome P450 3A4 are commonly used within the…”
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Electrospray Ionization Mass Spectrometric Analysis of Intact Cytochrome P450:  Identification of Tienilic Acid Adducts to P450 2C9 by Koenigs, Luke L, Peter, Raimund M, Hunter, Ann P, Haining, Robert L, Rettie, Allan E, Friedberg, Thomas, Pritchard, Michael P, Shou, Magang, Rushmore, Thomas H, Trager, William F

“…A general scheme for the purification of baculovirus-expressed cytochrome P450s (P450s) from the crude insect cell pastes has been designed which renders the…”
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Halothane-Induced Liver Injury in Outbred Guinea Pigs:  Role of Trifluoroacetylated Protein Adducts in Animal Susceptibility by Bourdi, Mohammed, Amouzadeh, Hamid R, Rushmore, Thomas H, Martin, Jackie L, Pohl, Lance R

“…Halothane causes a mild form of liver injury in guinea pigs that appears to model the hepatotoxicity seen in approximately 20% of patients treated with this…”
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SUBSTRATE SPECIFICITY AND KINETIC PROPERTIES OF SEVEN HETEROLOGOUSLY EXPRESSED DOG CYTOCHROMES P450 by Shou, Magang, Norcross, Ryan, Sandig, Grit, Lu, Ping, Li, Yinghe, Lin, Yuh, Mei, Qin, Rodrigues, A David, Rushmore, Thomas H

“…Seven dog cytochromes P450 (P450s) were heterologously expressed in baculovirus-Sf21 insect cells. Of all enzymes examined, CYP1A1 exhibited high…”
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Inhibition Kinetics of Monoclonal Antibodies against Cytochromes P450 by Mei, Qin, Tang, Cuyue, Lin, Yuh, Rushmore, Thomas H, Shou, Magang

“…Monoclonal antibodies (MAbs) inhibitory to individual cytochromes P450 (P450s) are of tremendous utility in identification of P450s responsible for the…”
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Effect of quinidine on the 10-hydroxylation of R-warfarin: species differences and clearance projection by Chen, Qing, Tan, Eugene, Strauss, John R, Zhang, Zhoupeng, Fenyk-Melody, Judith E, Booth-Genthe, Catherine, Rushmore, Thomas H, Stearns, Ralph A, Evans, David C, Baillie, Thomas A, Tang, Wei

“…Stimulation by quinidine of warfarin metabolism in vitro was first demonstrated with liver microsomal preparations. We report herein that this drug interaction…”
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INDUCTION OF CYP1A IN THE BEAGLE DOG BY AN INHIBITOR OF KINASE INSERT DOMAIN-CONTAINING RECEPTOR: DIFFERENTIAL EFFECTS IN VITRO AND IN VIVO ON MRNA AND FUNCTIONAL ACTIVITY by GIBSON, Christopher R, LIN, Charles, RAAB, Conrad, LUU, Minh, MICHAEL, Aimee, PARIKH, Mona, CIECKO, Patrice, SUBRAMANIAN, Raju, KROLIKOWSKI, Paul, RODRIGUES, A. David, BAILLIE, Thomas A, RUSHMORE, Thomas H, SINGH, Rominder, BROWN, Cheri M, RICHARDS, Karen, BRUNNER, Janice, MICHEL, Kimberly, ADELSBERGER, Jennifer, CARLINI, Edward, BOOTHE-GENTHE, Catherine

“…Compound I [3-[5-(4-methanesulfonyl-piperazin-1-ylmethyl)-1 H -indol-2-yl]-1 H -quinolin-2-one] is a potent inhibitor of human kinase insert domain-containing…”
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Cytotoxicity of 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT) and analogues in wild type and CYP3A4 stably transfected HepG2 cells by Frederick, Douglas M., Jacinto, Erina Y., Patel, Niti N., Rushmore, Thomas H., Tchao, Ruy, Harvison, Peter J.

“…[Display omitted] ► 3-(3,5-Dichlorophenyl)-2,4-thiazolidinedione (DCPT) was cytotoxic in HepG2 cells. ► Cytotoxicity was enhanced in HepG2 cells transfected…”
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Cytochrome P450 pharmacogenetics in drug development: in vitro studies and clinical consequences by Rodrigues, A David, Rushmore, Thomas H

“…Members of the human cytochrome P450 (CYP) superfamily play a role in the metabolism of many drugs and several of them, CYP2D6, CYP2C9 and CYP2C19, have been…”
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Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor by Tang, C, Shou, M, Mei, Q, Rushmore, T H, Rodrigues, A D

“…In vitro studies were conducted to identify the cytochromes P450 (CYP) involved in the oxidative metabolism of celecoxib. The hydroxylation of celecoxib…”
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A Kinetic Model for the Metabolic Interaction of Two Substrates at the Active Site of Cytochrome P450 3A4 by Shou, Magang, Dai, Renke, Cui, Dan, Korzekwa, Kenneth R., Baillie, Thomas A., Rushmore, Thomas H.

“…In many cases, CYP3A4 exhibits unusual kinetic characteristics that result from the metabolism of multiple substrates that coexist at the active site. In the…”
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Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives by Shou, M, Mei, Q, Ettore, Jr, M W, Dai, R, Baillie, T A, Rushmore, T H

“…Cytochrome P450 3A4 (CYP3A4) plays a prominent role in the metabolism of a vast array of drugs and xenobiotics and exhibits broad substrate specificities. Most…”
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