Search Results - "Rushlow, Walter"

Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation by Hudson, Roger, Renard, Justine, Norris, Christopher, Rushlow, Walter J, Laviolette, Steven R

“…Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) differentially regulate salience attribution and psychiatric…”
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Adolescent Cannabinoid Exposure Induces a Persistent Sub-Cortical Hyper-Dopaminergic State and Associated Molecular Adaptations in the Prefrontal Cortex by Renard, Justine, Rosen, Laura G, Loureiro, Michael, De Oliveira, Cleusa, Schmid, Susanne, Rushlow, Walter J, Laviolette, Steven R

“…Considerable evidence suggests that adolescent exposure to delta-9-tetrahydrocanabinol (THC), the psychoactive component in marijuana, increases the risk of…”
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What Can Rats Tell Us about Adolescent Cannabis Exposure? Insights from Preclinical Research by Renard, Justine, Rushlow, Walter J., Laviolette, Steven R.

“…Marijuana is the most widely used drug of abuse among adolescents. Adolescence is a vulnerable period for brain development, during which time various…”
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Cannabidiol Counteracts Amphetamine-Induced Neuronal and Behavioral Sensitization of the Mesolimbic Dopamine Pathway through a Novel mTOR/p70S6 Kinase Signaling Pathway by Renard, Justine, Loureiro, Michael, Rosen, Laura G, Zunder, Jordan, de Oliveira, Cleusa, Schmid, Susanne, Rushlow, Walter J, Laviolette, Steven R

“…Schizophrenia-related psychosis is associated with disturbances in mesolimbic dopamine (DA) transmission, characterized by hyperdopaminergic activity in the…”
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Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disruption of GABAergic Inhibition and Dysregulation of Sub-Cortical Dopamine Function by Renard, Justine, Szkudlarek, Hanna J., Kramar, Cecilia P., Jobson, Christina E. L., Moura, Kyra, Rushlow, Walter J., Laviolette, Steven R.

“…Chronic adolescent marijuana use has been linked to the later development of psychiatric diseases such as schizophrenia. GABAergic hypofunction in the…”
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Effects of Adolescent THC Exposure on the Prefrontal GABAergic System: Implications for Schizophrenia-Related Psychopathology by Renard, Justine, Rushlow, Walter J, Laviolette, Steven R

“…Marijuana is the most commonly used drug of abuse among adolescents. Considerable clinical evidence supports the hypothesis that adolescent neurodevelopmental…”
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Inhibition of fatty acid binding protein-5 in the basolateral amygdala induces anxiolytic effects and accelerates fear memory extinction by Jones, Matthew J., Uzuneser, Taygun C., Clement, Timothy, Wang, Hehe, Ojima, Iwao, Rushlow, Walter J., Laviolette, Steven R.

“…Rationale The endocannabinoid (eCB) system critically controls anxiety and fear-related behaviours. Anandamide (AEA), a prominent eCB ligand, is a hydrophobic…”
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Prenatal tetrahydrocannabinol and cannabidiol exposure produce sex-specific pathophysiological phenotypes in the adolescent prefrontal cortex and hippocampus by DeVuono, Marieka V., Nashed, Mina G., Sarikahya, Mohammed H., Kocsis, Andrea, Lee, Kendrick, Vanin, Sebastian R., Hudson, Roger, Lonnee, Eryn P., Rushlow, Walter J., Hardy, Daniel B., Laviolette, Steven R.

“…Clinical and preclinical evidence has demonstrated an increased risk for neuropsychiatric disorders following prenatal cannabinoid exposure. However, given the…”
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l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry by De Felice, Marta, Renard, Justine, Hudson, Roger, Szkudlarek, Hanna J, Pereira, Brian J, Schmid, Susanne, Rushlow, Walter J, Laviolette, Steven R

“…Chronic adolescent exposure to Δ-9-tetrahydrocannabinol (THC) is linked to elevated neuropsychiatric risk and induces neuronal, molecular and behavioral…”
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Anxiety and cognitive-related effects of Δ 9-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats by Hudson, Roger, Norris, Christopher, Szkudlarek, Hanna J., Khan, Dinat, Schmid, Susanne, Rushlow, Walter J., Laviolette, Steven R.

“…Rationale Δ 9 -tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis and is responsible for cannabis-related neuropsychiatric side…”
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Identification of a novel fatty acid binding protein-5-CB2 receptor-dependent mechanism regulating anxiety behaviors in the prefrontal cortex by Uzuneser, Taygun C, Szkudlarek, Hanna J, Jones, Matthew J, Nashed, Mina G, Clement, Timothy, Wang, Hehe, Ojima, Iwao, Rushlow, Walter J, Laviolette, Steven R

“…Abstract The endocannabinoid (eCB) system represents a promising neurobiological target for novel anxiolytic pharmacotherapies. Previous clinical and…”
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THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways by Szkudlarek, Hanna J., Rodríguez-Ruiz, Mar, Hudson, Roger, De Felice, Marta, Jung, Tony, Rushlow, Walter J., Laviolette, Steven R.

“…•Intra-PFC infusion of THC and CBD lead to divergent behavioural and molecular profiles.•THC facilitates panic-like behaviour that can be prevented by…”
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Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system by Ng, Tsun Hay Jason, Sarikahya, Mohammed H, Hudson, Roger, Szkudlarek, Hanna J, Pérez-Valenzuela, Enzo, Uzuneser, Taygun C, Proud, Emma, Gummerson, Dana, Youssef, Miray, Machado, Madeline, Zhaksylyk, Kuralay, DeVuono, Marieka V, Chen, Chaochao, Yeung, Ken K-C, Rushlow, Walter J, Laviolette, Steven R

“…The majority of lifetime smokers begin using nicotine during adolescence, a critical period of brain development wherein neural circuits critical for mood,…”
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Opiate exposure state controls dopamine D3 receptor and cdk5/calcineurin signaling in the basolateral amygdala during reward and withdrawal aversion memory formation by Rosen, Laura G., Rushlow, Walter J., Laviolette, Steven R.

“…The dopamine (DA) D3 receptor (D3R) is highly expressed in the basolateral nucleus of the amygdala (BLA), a neural region critical for processing…”
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Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions by De Felice, Marta, Chen, Chaochao, Rodríguez-Ruiz, Mar, Szkudlarek, Hanna J, Lam, Michael, Sert, Selvi, Whitehead, Shawn N, Yeung, Ken K-C, Rushlow, Walter J, Laviolette, Steven R

“…Chronic exposure to Δ-9-tetrahydrocannabinol (THC) during adolescence is associated with long-lasting cognitive impairments and enhanced susceptibility to…”
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Adolescent nicotine induces depressive and anxiogenic effects through ERK 1‐2 and Akt‐GSK‐3 pathways and neuronal dysregulation in the nucleus accumbens by Hudson, Roger, Green, Matthew, Wright, Daniel J., Renard, Justine, Jobson, Christina E.L., Jung, Tony, Rushlow, Walter, Laviolette, Steven R.

“…Long‐term tobacco dependence typically develops during adolescence and neurodevelopmental nicotine exposure is associated with affective disturbances that…”
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NMDA Receptor Blockade in the Prelimbic Cortex Activates the Mesolimbic System and Dopamine-Dependent Opiate Reward Signaling by Tan, Huibing, Rosen, Laura G., Ng, Garye A., Rushlow, Walter J., Laviolette, Steven R.

“…Rationale N-Methyl- d -aspartate (NMDA) receptors in the medial prefrontal cortex (mPFC) are involved in opiate reward processing and modulate sub-cortical…”
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Activation of the canonical Wnt pathway by the antipsychotics haloperidol and clozapine involves dishevelled-3 by Sutton, Laurie P, Honardoust, Dariush, Mouyal, Joanne, Rajakumar, Nagalingam, Rushlow, Walter J

“…Protein kinase B (Akt), glycogen synthase kinase-3 (GSK-3) and members of the Wnt signal transduction pathway were recently found to be altered in…”
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The Impacts of Adolescent Cannabinoid Exposure on Striatal Anxiety- and Depressive-Like Pathophysiology Are Prevented by the Antioxidant N-Acetylcysteine by De Felice, Marta, Szkudlarek, Hanna J., Uzuneser, Taygun C., Rodríguez-Ruiz, Mar, Sarikahya, Mohammed H., Pusparajah, Mathusha, Galindo Lazo, Juan Pablo, Whitehead, Shawn N., Yeung, Ken K.-C., Rushlow, Walter J., Laviolette, Steven R.

“…Exposure to Δ9-tetrahydrocannabinol (THC) is an established risk factor for later-life neuropsychiatric vulnerability, including mood- and anxiety-related…”
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Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268 by Sutton, Laurie P., Rushlow, Walter J.

“…J. Neurochem. (2011) 117, 973–983. Metabotropic glutamate receptors 2/3 (mGlu2/3) have been implicated in schizophrenia and as a novel treatment target for…”
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