Search Results - "Rushing, R"

Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods by Rushing, Blake R., Selim, Mustafa I.

“…Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi and are known to contaminate a large portion of the world's food supply…”
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Multi-Omics Analysis of NCI-60 Cell Line Data Reveals Novel Metabolic Processes Linked with Resistance to Alkylating Anti-Cancer Agents by Rushing, Blake R

“…This study aimed to elucidate the molecular determinants influencing the response of cancer cells to alkylating agents, a major class of chemotherapeutic drugs…”
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Metabolomics Analysis Reveals Novel Targets of Chemosensitizing Polyphenols and Omega-3 Polyunsaturated Fatty Acids in Triple Negative Breast Cancer Cells by Rushing, Blake R, Wiggs, Alleigh, Molina, Sabrina, Schroder, Madison, Sumner, Susan

“…Triple negative breast cancer (TNBC) is a subtype of breast cancer with typically poorer outcomes due to its aggressive clinical behavior and lack of targeted…”
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Unlocking the Molecular Secrets of Antifolate Drug Resistance: A Multi-Omics Investigation of the NCI-60 Cell Line Panel by Rushing, Blake R

“…Drug resistance continues to be a significant problem in cancer therapy, leading to relapse and associated mortality. Although substantial progress has been…”
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A Review of Metabolic Targets of Anticancer Nutrients and Nutraceuticals in Pre-Clinical Models of Triple-Negative Breast Cancer by Wiggs, Alleigh, Molina, Sabrina, Sumner, Susan J, Rushing, Blake R

“…Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is notoriously aggressive and has poorer outcomes as compared with other breast cancer…”
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Maternal Serum Metabolomics in Mid-Pregnancy Identifies Lipid Pathways as a Key Link to Offspring Obesity in Early Childhood by Francis, Ellen C, Kechris, Katerina, Johnson, Randi K, Rawal, Shristi, Pathmasiri, Wimal, Rushing, Blake R, Du, Xiuxia, Jansson, Thomas, Dabelea, Dana, Sumner, Susan J, Perng, Wei

“…Maternal metabolism during pregnancy shapes offspring health via in utero programming. In the Healthy Start study, we identified five subgroups of pregnant…”
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Metabolomics Analysis Reveals Altered Metabolic Pathways and Response to Doxorubicin in Drug-Resistant Triple-Negative Breast Cancer Cells by Rushing, Blake R, Molina, Sabrina, Sumner, Susan

“…This study aimed to investigate metabolic changes following the acquisition of resistance to doxorubicin in the triple-negative breast cancer (TNBC) cell line…”
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Untargeted metabolomics reveal signatures of a healthy lifestyle by Pathmasiri, Wimal, Rushing, Blake R., McRitchie, Susan, Choudhari, Mansi, Du, Xiuxia, Smirnov, Alexsandr, Pelleigrini, Matteo, Thompson, Michael J., Sakaguchi, Camila A., Nieman, David C., Sumner, Susan J.

“…This cross-sectional study investigated differences in the plasma metabolome in two groups of adults that were of similar age but varied markedly in body…”
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Fecal metabolomics reveals products of dysregulated proteolysis and altered microbial metabolism in obesity-related osteoarthritis by Rushing, B.R., McRitchie, S., Arbeeva, L., Nelson, A.E., Azcarate-Peril, M.A., Li, Y.-Y., Qian, Y., Pathmasiri, W., Sumner, S.C.J., Loeser, R.F.

“…The objective of this exploratory study was to determine if perturbations in gut microbial composition and the gut metabolome could be linked to individuals…”
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Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions by Rushing, Blake R, Fogle, Halle M, Sharma, Jaspreet, You, Mikyoung, McCormac, Jonathan P, Molina, Sabrina, Sumner, Susan, Krupenko, Natalia I, Krupenko, Sergey A

“…Folate (vitamin B9) is involved in one-carbon transfer reactions and plays a significant role in nucleic acid synthesis and control of cellular proliferation,…”
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Multi-omics analysis of glucose-mediated signaling by a moonlighting Gβ protein Asc1/RACK1 by Li, Shuang, Li, Yuanyuan, Rushing, Blake R., Harris, Sarah E., McRitchie, Susan L., Jones, Janice C., Dominguez, Daniel, Sumner, Susan J., Dohlman, Henrik G.

“…Heterotrimeric G proteins were originally discovered through efforts to understand the effects of hormones, such as glucagon and epinephrine, on glucose…”
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Comparison of Lysis and Detachment Sample Preparation Methods for Cultured Triple-Negative Breast Cancer Cells Using UHPLC-HRMS-Based Metabolomics by Rushing, Blake R, Schroder, Madison, Sumner, Susan C J

“…Dysregulation of cellular metabolism is now a well-recognized hallmark of cancer. Studies investigating the metabolic features of cancer cells have shed new…”
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Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery by Rushing, Blake R, Rohlik, Denise L, Roy, Sourav, Skaff, D Andrew, Garcia, Brandon L

“…The initiating protease of the complement classical pathway, C1r, represents an upstream and pathway-specific intervention point for complement-related…”
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Baseline Serum Biomarkers Predict Response to a Weight Loss Intervention in Older Adults with Obesity: A Pilot Study by Lynch, David H, Rushing, Blake R, Pathmasiri, Wimal, McRitchie, Susan, Batchek, Dakota J, Petersen, Curtis L, Gross, Danae C, Sumner, Susan C J, Batsis, John A

“…Caloric restriction and aerobic and resistance exercise are safe and effective lifestyle interventions for achieving weight loss in the obese older population…”
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Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer by Fennell, Emily M J, Aponte-Collazo, Lucas J, Pathmasiri, Wimal, Rushing, Blake R, Barker, Natalie K, Partridge, Megan C, Li, Yuan-Yuan, White, Cody A, Greer, Yoshimi E, Herring, Laura E, Lipkowitz, Stanley, Sumner, Susan C J, Iwanowicz, Edwin J, Graves, Lee M

“…ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in and studies,…”
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Multi-Omics Analysis of Multiple Glucose-Sensing Receptor Systems in Yeast by Li, Shuang, Li, Yuanyuan, Rushing, Blake R, Harris, Sarah E, McRitchie, Susan L, Dominguez, Daniel, Sumner, Susan J, Dohlman, Henrik G

“…The yeast has long been used to produce alcohol from glucose and other sugars. While much is known about glucose metabolism, relatively little is known about…”
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Benign metastasizing leiomyoma, a rare imposter of metastatic cervical cancer by Whang, S.G., Gholson, M., Rushing, R.S.

“…•Differential for necrotic pelvic mass with pulmonary nodules.•Benign metastasizing leiomyoma in woman with limited surgical history.•Efficacy of estrogen…”
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Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and Aldh1l1 Knockout Mice by Sharma, Jaspreet, Rushing, Blake R, Hall, Madeline S, Helke, Kristi L, McRitchie, Susan L, Krupenko, Natalia I, Sumner, Susan J, Krupenko, Sergey A

“…ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism, is highly expressed in the liver. It regulates the overall flux of…”
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Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in C57BL/6 mice by Rushing, Blake R, Hu, Qing, Franklin, Jason N, McMahen, Rebecca, Dagnino, Sonia, Higgins, Christopher P, Strynar, Mark J, DeWitt, Jamie C

“…2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate was designed to replace perfluorooctanoic acid (PFOA), which has been mostly phased out of U.S…”
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Magnetic resonance imaging in dogs with neurologic impairment due to acute thoracic and lumbar intervertebral disk herniation by Levine, J.M, Fosgate, G.T, Chen, A.V, Rushing, R, Nghiem, P.P, Platt, S.R, Bagley, R.S, Kent, M, Hicks, D.G, Young, B.D, Schatzberg, S.J

“…Background: Magnetic resonance imaging (MRI) is a correlate to physical examination in various myelopathies and a predictor of functional outcome. Objectives:…”
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