Search Results - "Rushefski, Melanie"

Local complement activation is associated with primary graft dysfunction after lung transplantation by Kulkarni, Hrishikesh S, Ramphal, Kristy, Ma, Lina, Brown, Melanie, Oyster, Michelle, Speckhart, Kaitlyn N, Takahashi, Tsuyoshi, Byers, Derek E, Porteous, Mary K, Kalman, Laurel, Hachem, Ramsey R, Rushefski, Melanie, McPhatter, Ja'Nia, Cano, Marlene, Kreisel, Daniel, Scavuzzo, Masina, Mittler, Brigitte, Cantu, 3rd, Edward, Pilely, Katrine, Garred, Peter, Christie, Jason D, Atkinson, John P, Gelman, Andrew E, Diamond, Joshua M

“…BACKGROUNDThe complement system plays a key role in host defense but is activated by ischemia/reperfusion injury (IRI). Primary graft dysfunction (PGD) is a…”
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SNP-set analysis replicates acute lung injury genetic risk factors by Meyer, Nuala J, Daye, Zhongyin John, Rushefski, Melanie, Aplenc, Richard, Lanken, Paul N, Shashaty, Michael G S, Christie, Jason D, Feng, Rui

“…We used a gene - based replication strategy to test the reproducibility of prior acute lung injury (ALI) candidate gene associations. We phenotyped 474…”
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Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma by Rushefski, Melanie, Aplenc, Richard, Meyer, Nuala, Li, Mingyao, Feng, Rui, Lanken, Paul N, Gallop, Robert, Bellamy, Scarlett, Localio, A Russell, Feinstein, Sheldon I, Fisher, Aron B, Albelda, Steven M, Christie, Jason D

“…Peroxiredoxin 6 (PRDX6) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Little is known about genetic…”
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Frailty Phenotypes, Disability, and Outcomes in Adult Candidates for Lung Transplantation by Singer, Jonathan P, Diamond, Joshua M, Gries, Cynthia J, McDonnough, Jamiela, Blanc, Paul D, Shah, Rupal, Dean, Monica Y, Hersh, Beverly, Wolters, Paul J, Tokman, Sofya, Arcasoy, Selim M, Ramphal, Kristy, Greenland, John R, Smith, Nancy, Heffernan, Pricilla, Shah, Lori, Shrestha, Pavan, Golden, Jeffrey A, Blumenthal, Nancy P, Huang, Debbie, Sonett, Joshua, Hays, Steven, Oyster, Michelle, Katz, Patricia P, Robbins, Hilary, Brown, Melanie, Leard, Lorriana E, Kukreja, Jasleen, Bacchetta, Matthew, Bush, Errol, D'Ovidio, Frank, Rushefski, Melanie, Raza, Kashif, Christie, Jason D, Lederer, David J

“…Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined in lung transplantation. To examine the…”
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Early Tacrolimus Concentrations After Lung Transplant Are Predicted by Combined Clinical and Genetic Factors and Associated With Acute Kidney Injury by Miano, Todd A., Flesch, Judd D., Feng, Rui, Forker, Caitlin M., Brown, Melanie, Oyster, Michelle, Kalman, Laurel, Rushefski, Melanie, Cantu, Edward, Porteus, Mary, Yang, Wei, Localio, A. Russel, Diamond, Joshua M., Christie, Jason D., Shashaty, Michael G.S.

“…Tacrolimus exhibits unpredictable pharmacokinetics (PKs) after lung transplant, partly explained by cytochrome P450 (CYP)–enzyme polymorphisms. However,…”
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Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study by Anderson, Michaela R., Udupa, Jayaram K., Edwin, Ethan, Diamond, Joshua M., Singer, Jonathan P., Kukreja, Jasleen, Hays, Steven R., Greenland, John R., Ferrante, Anthony, Lippel, Matthew, Blue, Tatiana, McBurnie, Amika, Oyster, Michelle, Kalman, Laurel, Rushefski, Melanie, Wu, Caiyun, Pednekar, Gargi, Liu, Wen, Arcasoy, Selim, Sonett, Joshua, D'Ovidio, Frank, Bacchetta, Matthew, Newell, John D., Torigian, Drew, Cantu, Edward, Farber, Donna L., Giles, Jon T., Tong, Yubing, Palmer, Scott, Ware, Lorraine B., Hancock, Wayne W., Christie, Jason D., Lederer, David J.

“…Obesity is associated with an increased risk of primary graft dysfunction (PGD) after lung transplantation. The contribution of specific adipose tissue depots…”
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IL1RN Coding Variant Is Associated with Lower Risk of Acute Respiratory Distress Syndrome and Increased Plasma IL-1 Receptor Antagonist by MEYER, Nuala J, RUI FENG, APLENC, Richard, O'KEEFE, Grant E, WURFEL, Mark M, CHRISTIANI, David C, CHRISTIE, Jason D, MINGYAO LI, YANG ZHAO, SHEU, Chau-Chyun, TEJERA, Paula, GALLOP, Robert, BELLAMY, Scarlett, RUSHEFSKI, Melanie, LANKEN, Paul N

“…Acute respiratory distress syndrome (ARDS) behaves as a complex genetic trait, yet knowledge of genetic susceptibility factors remains incomplete. To identify…”
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ANGPT2 Genetic Variant Is Associated with Trauma-associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio by MEYER, Nuala J, MINGYAO LI, APLENC, Richard, ABRAMOVA, Helen, ATOCHINA-VASSERMAN, Elena N, BEERS, Michael F, CALFEE, Carolyn S, COHEN, Mitchell J, PITTET, Jean-Francois, CHRISTIANI, David C, O'KEEFE, Grant E, WARE, Lorraine B, RUI FENG, MAY, Addison K, WURFEL, Mark M, HAKONARSON, Hakon, CHRISTIE, Jason D, BRADFIELD, Jonathan, GALLOP, Robert, BELLAMY, Scarlett, FUCHS, Barry D, LANKEN, Paul N, ALBELDA, Steven M, RUSHEFSKI, Melanie

“…Acute lung injury (ALI) acts as a complex genetic trait, yet its genetic risk factors remain incompletely understood. Large-scale genotyping has not previously…”
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Variation in PTX3 Is Associated with Primary Graft Dysfunction after Lung Transplantation by DIAMOND, Joshua M, MEYER, Nuala J, BHORADE, Sangeeta, CRESPO, Maria, DEMISSIE, Ejigayehu, SONETT, Joshua, WILLE, Keith, ORENS, Jonathan, WEINACKER, Ann, WEILL, David, ARCASOY, Selim, SHAH, Pali D, FENG, Rui, BELPERIO, John A, WILES, David, WARE, Lorraine B, PALMER, Scott M, CHRISTIE, Jason D, RUSHEFSKI, Melanie, LEDERER, David J, KAWUT, Steven M, LEE, James C, CANTU, Edward, SHAHE, Rupal J, LAMA, Vibha N

“…Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in…”
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Integrative genomics identifies 7p11.2 as a novel locus for fever and clinical stress response in humans by Ferguson, Jane F, Meyer, Nuala J, Qu, Liming, Xue, Chenyi, Liu, Yichuan, DerOhannessian, Stephanie L, Rushefski, Melanie, Paschos, Georgios K, Tang, Soonyew, Schadt, Eric E, Li, Mingyao, Christie, Jason D, Reilly, Muredach P

“…Fever predicts clinical outcomes in sepsis, trauma and during cardiovascular stress, yet the genetic determinants are poorly understood. We used an integrative…”
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The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia by Diamond, Joshua M., MD, MS, Porteous, Mary K., MD, MS, Jackson Roberts, L., MD, Wickersham, Nancy, BS, Rushefski, Melanie, Kawut, Steven M., MD, MS, Shah, Rupal J., MD, MS, Cantu, Edward, MD, MS, Lederer, David J., MD, MS, Chatterjee, Shampa, PhD, Lama, Vibha N., MD, MS, Bhorade, Sangeeta, MD, Crespo, Maria, MD, McDyer, John, MD, Wille, Keith, MD, Orens, Jonathan, MD, Weinacker, Ann, MD, Arcasoy, Selim, MD, Shah, Pali D., MD, Wilkes, David S., MD, Hage, Chadi, MD, Palmer, Scott M., MD, MHS, Snyder, Laurie, MD, Calfee, Carolyn S., MD, Ware, Lorraine B., MD, Christie, Jason D., MD, MS

“…Background Donor smoking history and higher fraction of inspired oxygen (F io2 ) at reperfusion are associated with primary graft dysfunction (PGD) after lung…”
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Abstract 13251: Experimental Endotoxemia Uncovers a Genomic Basis for Thermoregulation: Chr7p11.2 Locus in Inflammatory Febrile Response and Temperature Homeostasis by Ferguson, Jane F., Meyer, Nuala J., Qu, Liming, Xue, Chenyi, Liu, Yichuan, DerOhannessian, Stephanie L., Rushefski, Melanie, Schadt, Eric E., Li, Mingyao, Christie, Jason D., Reilly, Muredach P.

“…Abstract only Jane Ferguson, 2013 Finalist and Presenting Author…”
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Adipose Gene Expression Profile Changes With Lung Allograft Reperfusion by Diamond, J. M., Arcasoy, S., McDonnough, J. A., Sonett, J. R., Bacchetta, M., D'Ovidio, F., Cantu, E., Bermudez, C. A., McBurnie, A., Rushefski, M., Kalman, L. H., Oyster, M., D'Errico, C., Suzuki, Y., Giles, J. T., Ferrante, A., Lippel, M., Singh, G., Lederer, D. J., Christie, J. D.

“…Obesity is a risk factor for primary graft dysfunction (PGD), a form of lung injury resulting from ischemia–reperfusion after lung transplantation, but the…”
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