Search Results - "Rush, David N."

HLA-DR/DQ molecular mismatch: A prognostic biomarker for primary alloimmunity by Wiebe, Chris, Kosmoliaptsis, Vasilis, Pochinco, Denise, Gibson, Ian W., Ho, Julie, Birk, Patricia E., Goldberg, Aviva, Karpinski, Martin, Shaw, Jamie, Rush, David N., Nickerson, Peter W.

“…Alloimmune risk stratification in renal transplantation has lacked the necessary prognostic biomarkers to personalize recipient care or optimize clinical…”
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Class II Eplet Mismatch Modulates Tacrolimus Trough Levels Required to Prevent Donor-Specific Antibody Development by Wiebe, Chris, Rush, David N, Nevins, Thomas E, Birk, Patricia E, Blydt-Hansen, Tom, Gibson, Ian W, Goldberg, Aviva, Ho, Julie, Karpinski, Martin, Pochinco, Denise, Sharma, Atul, Storsley, Leroy, Matas, Arthur J, Nickerson, Peter W

“…Despite more than two decades of use, the optimal maintenance dose of tacrolimus for kidney transplant recipients is unknown. We hypothesized that HLA class II…”
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Serum Creatinine Measurement Immediately After Cardiac Surgery and Prediction of Acute Kidney Injury by Ho, Julie, MD, Reslerova, Martina, MD, PhD, Gali, Brent, BSc, Nickerson, Peter W., MD, Rush, David N., MD, Sood, Manish M., MD, Bueti, Joe, MD, Komenda, Paul, MD, Pascoe, Edward, MD, Arora, Rakesh C., MD, Rigatto, Claudio, MD, FRCPC, MSc

“…Background After heart surgery, acute kidney injury (AKI) confers substantial long-term risk of death and chronic kidney disease. We hypothesized that small…”
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Urinary Hepcidin-25 and Risk of Acute Kidney Injury Following Cardiopulmonary Bypass by Ho, Julie, Reslerova, Martina, Gali, Brent, Gao, Ang, Bestland, Jennifer, Rush, David N, Nickerson, Peter W, Rigatto, Claudio

“…Acute kidney injury (AKI) complicating cardiopulmonary bypass (CPB) results in increased morbidity and mortality. Urinary hepcidin-25 has been shown to be…”
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Immune Monitoring of Kidney Allografts by Ho, Julie, MD, Wiebe, Chris, MD, Gibson, Ian W., MD, Rush, David N., MD, Nickerson, Peter W., MD

“…Current strategies for posttransplant monitoring of kidney transplants consist of measuring serial serum creatinine levels, clinical follow-up, and in some…”
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Neointimal and Tubulointerstitial Infiltration by Recipient Mesenchymal Cells in Chronic Renal-Allograft Rejection by Grimm, Paul C, Nickerson, Peter, Jeffery, John, Savani, Rashmin C, Gough, James, McKenna, Rachel M, Stern, Elzbieta, Rush, David N

“…Tissue remodeling is central to the pathogenesis of many chronic illnesses. In the vascular narrowing of atherosclerosis, 1 the proliferation of smooth-muscle…”
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Subclinical Inflammation in Renal Transplantation by Rush, David N, Gibson, Ian W

“…The standardization of renal allograft pathology began in 1991 at the first Banff Conference held in Banff, Alberta, Canada. The first task of transplant…”
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The negative impact of T cell–mediated rejection on renal allograft survival in the modern era by Rampersad, Christie, Balshaw, Robert, Gibson, Ian W., Ho, Julie, Shaw, Jamie, Karpinski, Martin, Goldberg, Aviva, Birk, Patricia, Rush, David N., Nickerson, Peter W., Wiebe, Chris

“…The prevalence and long‐term impact of T cell–mediated rejection (TCMR) is poorly defined in the modern era of tacrolimus/mycophenolate‐based maintenance…”
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Proteomic characterization of serine hydrolase activity and composition in normal urine by Navarrete, Mario, Ho, Julie, Krokhin, Oleg, Ezzati, Peyman, Rigatto, Claudio, Reslerova, Martina, Rush, David N, Nickerson, Peter, Wilkins, John A

“…Serine hydrolases constitute a large enzyme family involved in a diversity of proteolytic and metabolic processes which are essential for many aspects of…”
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Prevalence and treatment of decreased bone density in renal transplant recipients: A randomized prospective trial of calcitriol versus alendronate by JEFFERY, John R, LESLIE, William D, KARPINSKI, Martin E, NICKERSON, Peter W, RUSH, David N

“…Reduced bone mineral density (BMD) is common in long-term renal transplant recipients and results in a high incidence of fractures. The optimal therapy for…”
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Evidence for the alloimmune basis and prognostic significance of Borderline T cell–mediated rejection by Wiebe, Chris, Rush, David N., Gibson, Ian W., Pochinco, Denise, Birk, Patricia E., Goldberg, Aviva, Blydt‐Hansen, Tom, Karpinski, Martin, Shaw, Jamie, Ho, Julie, Nickerson, Peter W.

“…Prognostic biomarkers of T cell–mediated rejection (TCMR) have not been adequately studied in the modern era. We evaluated 803 renal transplant recipients and…”
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A rational approach to guide cost-effective de novo donor-specific antibody surveillance with tacrolimus immunosuppression by Wiebe, Chris, Balshaw, Rob, Gibson, Ian W., Ho, Julie, Shaw, Jamie, Karpinski, Martin, Trachtenberg, Aaron, Pochinco, Denise, Goldberg, Aviva, Birk, Patricia, Pinsk, Maury, Rush, David N., Nickerson, Peter W.

“…De novo donor-specific antibody (dnDSA) after renal transplantation has been shown to correlate with antibody-mediated rejection and allograft loss. However,…”
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Early Antibody-Mediated Kidney Transplant Rejection Associated With Anti-Vimentin Antibodies: A Case Report by Rampersad, Christie, Shaw, James, Gibson, Ian W., Wiebe, Chris, Rush, David N., Nickerson, Peter W., Ho, Julie

“…Improving precision in predicting alloreactivity is an important unmet need and may require individualized consideration of non-HLA antibodies. We report a…”
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Six-Month Urinary CCL2 and CXCL10 Levels Predict Long-term Renal Allograft Outcome by Hirt-Minkowski, Patricia, Rush, David N, Gao, Ang, Hopfer, Helmut, Wiebe, Chris, Nickerson, Peter W, Schaub, Stefan, Ho, Julie

“…BACKGROUNDEarly prognostic markers that identify high-risk patients could lead to increased surveillance, personalized immunosuppression, and improved…”
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Carpe diem—Time to transition from empiric to precision medicine in kidney transplantation by Wiebe, Chris, Ho, Julie, Gibson, Ian W., Rush, David N., Nickerson, Peter W.

“…The current immunosuppressive pipeline in kidney transplantation is limited. In part, this is due to excellent one‐year allograft outcomes with the current…”
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Activity-based Protein Profiling Approaches for Transplantation by Navarrete, Mario, Wilkins, John A, Lao, Ying, Rush, David N, Nickerson, Peter W, Ho, Julie

“…Enzyme activity may be more pathophysiologically relevant than enzyme quantity and is regulated by changes in conformational status that are undetectable by…”
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A noninferiority design for a delayed calcineurin inhibitor substitution trial in kidney transplantation by Nickerson, Peter W., Balshaw, Robert, Wiebe, Chris, Ho, Julie, Gibson, Ian W., Bridges, Nancy D., Rush, David N., Heeger, Peter S.

“…Improving long‐term kidney transplant outcomes requires novel treatment strategies, including delayed calcineurin inhibitor (CNI) substitution, tested using…”
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Association of BKV viremia and nephropathy with adverse alloimmune outcomes in kidney transplant recipients by Rampersad, Christie, Wiebe, Chris, Balshaw, Robert, Bullard, Jared, Gibson, Ian W., Trachtenberg, Aaron, Shaw, James, Villalobos, Armelle Perez Cortes, Karpinski, Martin, Goldberg, Aviva, Birk, Patricia, Pinsk, Maury, Rush, David N., Nickerson, Peter W., Ho, Julie

“…Background Immunosuppression reduction for BK polyoma virus (BKV) must be balanced against risk of adverse alloimmune outcomes. We sought to characterize risk…”
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Begin at the Beginning to Prevent the End by Nickerson, Peter W, Rush, David N

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FRAX predicts fracture risk in kidney transplant recipients by Naylor, Kyla L, Leslie, William D, Hodsman, Anthony B, Rush, David N, Garg, Amit X

“…The World Health Organization Fracture Risk Assessment Tool (FRAX) estimates the 10-year fracture probability. We assessed the prognostic value of FRAX in…”
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