Search Results - "Rush, Bob D"

Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses by Brideau, Roger J., Knechtel, Mary L., Huang, Audris, Vaillancourt, Valerie A., Vera, Ellen E., Oien, Nancee L., Hopkins, Todd A., Wieber, Janet L., Wilkinson, Karen F., Rush, Bob D., Schwende, Francis J., Wathen, Michael W.

“…We identified a novel class of 4-oxo-dihydroquinolines represented by PNU-183792 which specifically inhibit herpesvirus polymerases. PNU-183792 was highly…”
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7-Oxo-4,7-dihydrothieno[3,2- b]pyridine-6-carboxamides: Synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase by Larsen, Scott D., Zhang, Zhijun, DiPaolo, Brian A., Manninen, Peter R., Rohrer, Douglas C., Hageman, Michael J., Hopkins, Todd A., Knechtel, Mary L., Oien, Nancee L., Rush, Bob D., Schwende, Francis J., Stefanski, Kevin J., Wieber, Janet L., Wilkinson, Karen F., Zamora, Kathyrn M., Wathen, Michael W., Brideau, Roger J.

“…A new class of non-nucleoside antivirals is reported, wherein a C-3 methyl group confers dramatic improvement in potency, perhaps due to conformational…”
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Peptide to glycopeptide: glycosylated oligopeptide renin inhibitors with attenuated in vivo clearance properties by Fisher, Jed F, Harrison, Allen W, Bundy, Gordon L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J

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Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities by Chong, Kong Teck, Ruwart, Mary J, Hinshaw, Roger R, Wilkinson, Karen F, Rush, Bob D, Yancey, Mark F, Strohbach, Joseph W, Thaisrivongs, Suvit

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Effects of alteration of hepatic microsomal enzyme activity on liver blood flow in the rat by Nies, A S, Wilkinson, G R, Rush, B D, Strother, J R, McDevitt, D G

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Adrenergic and cholinergic contributions to decreased gastric emptying, small intestinal transit, and colonic transit in the postoperative ileus rat by Ruwart, M J, Klepper, M S, Rush, B D

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Structure-Based Design of HIV Protease Inhibitors: 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Non-peptidic Inhibitors by Thaisrivongs, Suvit, Tomich, Paul K, Watenpaugh, Keith D, Chong, Kong-Teck, Howe, W. Jeffrey, Yang, Chih-Ping, Strohbach, Joseph W, Turner, Steve R, McGrath, James P

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Structure-Based Design of Nonpeptidic HIV Protease Inhibitors:  The Sulfonamide-Substituted Cyclooctylpyranones by Skulnick, Harvey I, Johnson, Paul D, Aristoff, Paul A, Morris, Jeanette K, Lovasz, Kristine D, Howe, W. Jeffrey, Watenpaugh, Keith D, Janakiraman, Musiri N, Anderson, David J, Reischer, Robert J, Schwartz, Theresa M, Banitt, Lee S, Tomich, Paul K, Lynn, Janet C, Horng, Miao-Miao, Chong, Kong-Teck, Hinshaw, Roger R, Dolak, Lester A, Seest, Eric P, Schwende, Francis J, Rush, Bob D, Howard, Gina M, Toth, Lisa N, Wilkinson, Karen R, Kakuk, Thomas J, Johnson, Carol W, Cole, Serena L, Zaya, Renee M, Zipp, Gail L, Possert, Peggy L, Dalga, Robert J, Zhong, Wei-Zhu, Williams, Marta G, Romines, Karen R

“…Recently, cyclooctylpyranone derivatives with m-carboxamide substituents (e.g. 2c) were identified as potent, nonpeptidic HIV protease inhibitors, but these…”
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Cyclosporine metabolism by P450IIIA in rat enterocytes--another determinant of oral bioavailability? by Kolars, J C, Stetson, P L, Rush, B D, Ruwart, M J, Schmiedlin-Ren, P, Duell, E A, Voorhees, J J, Watkins, P B

“…Cyclosporine is converted to its major metabolites (M-17, M-1, and M-21) in human liver by enzymes belonging to the P450IIIA subfamily. These enzymes are also…”
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Use of Medium-Sized Cycloalkyl Rings To Enhance Secondary Binding: Discovery of a New Class of Human Immunodeficiency Virus (HIV) Protease Inhibitors by Romines, Karen R, Watenpaugh, Keith D, Tomich, Paul K, Howe, W. Jeffrey, Morris, Jeanette K, Lovasz, Kristine D, Mulichak, Anne M, Finzel, Barry C, Lynn, Janet C

“…A unique strategy for the enhancement of secondary binding of an inhibitor to an enzyme has been demonstrated in the design of new human immunodeficiency virus…”
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The integrated value of serum procollagen III peptide over time predicts hepatic hydroxyproline content and stainable collagen in a model of dietary cirrhosis in the rat by Ruwart, M J, Wilkinson, K F, Rush, B D, Vidmar, T J, Peters, K M, Henley, K S, Appelman, H D, Kim, K Y, Schuppan, D, Hahn, E G

“…To determine whether a serum parameter of collagen metabolism, serum procollagen type III peptide, correlated with hepatic collagen in a model of diet-induced…”
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Desolvation energy : a major determinant of absorption, but not clearance, of peptides in rats by KARLS, M. S, RUSH, B. D, WILKINSON, K. F, VIDMAR, T. J, BURTON, P. S, RUWART, M. J

“…The oral delivery of peptidic drugs is problematic because of their degradation in the gastrointestinal tract and low absorption through the intestinal mucosa…”
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16,16-Dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver by Ruwart, M J, Rush, B D, Snyder, K F, Peters, K M, Appelman, H D, Henley, K S

“…Chronic nutritional injury was induced in rats by a high-fat, lipotrope-deficient diet. The hepatoprotective effect of 16,16-dimethyl prostaglandin E2 on the…”
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Evaluation of a vitamin-cloaking strategy for oligopeptide therapeutics: biotinylated HIV-1 protease inhibitors by Islam, I, Ng, K. Y, Chong, K. T, McQuade, T. J, Hui, J. O, Wilkinson, K. F, Rush, B. D, Ruwart, M. J, Borchardt, R. T, Fisher, J. F

“…The outstanding limitations to the oligopeptide as a therapeutic agent are poor oral availability and rapid biliary clearance. To address these concerns a…”
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Development of activity assays for high-volume evaluation of human immunodeficiency virus (HIV) protease inhibitors in rat serum : results with ditekiren by WILKINSON, K. F, RUSH, B. D, SHARMA, S. K, EVANS, D. B, RUWART, M. J, FRIIS, J. M, BOHANON, M. J, TOMICH, P. K

“…We showed previously that a commercially available synthetic tetradecapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, produces authentic…”
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The role of accelerated colonic transit in prostaglandin‐induced diarrhoea and its inhibition by prostacyclin by Rush, Bob D., Ruwart, Mary J.

“…1 Rats treated with subcutaneous 16,16‐dimethyl prostaglandin E2 (16,16‐dimethyl PGE2, 100 μg kg−1) exhibited diarrhoea even when their ileo‐caecal junctions…”
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Serum procollagen III peptide and hepatic hydroxyproline content by Tetri, B

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Development of a sensitive activity assay for high-volume evaluation of human renin inhibitory peptides in rat serum : results with U-71,038 by RUWART, M. J, SHARMA, S. K, JOHNSON, G. A, HARRIS, D. W, LAKINGS, D. B, RUSH, B. D, WILKINSON, K. F, CORNETTE, J. C, EVANS, D. B, FRIIS, J. M, COOK, K. J

“…A sensitive activity assay for high volume evaluation of human renin inhibitory peptides (RIPs) in rat sera (range 2-80 ng/ml) was developed based on the low…”
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Evaluation of lincomycin as a cholesterol gallstone dissolution rate accelerator by Rush, B D, Ruwart, M J, Anderson, B D, Higuchi, W I

“…These studies were undertaken to test the hypothesis that interfacial resistance may be an important rate-limiting factor in cholesterol gallstone dissolution…”
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