Search Results - "Rush, B D"

In vitro/in vivo models for peptide oral absorption : comparison of caco-2 cell permeability with rat intestinal absorption of renin inhibitory peptides by CONRADI, R. A, WILKINSON, K. F, RUSH, B. D, HILGERS, A. R, RUWART, M. J, BURTON, P. S

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Cyclosporine metabolism by P450IIIA in rat enterocytes--another determinant of oral bioavailability? by Kolars, J C, Stetson, P L, Rush, B D, Ruwart, M J, Schmiedlin-Ren, P, Duell, E A, Voorhees, J J, Watkins, P B

“…Cyclosporine is converted to its major metabolites (M-17, M-1, and M-21) in human liver by enzymes belonging to the P450IIIA subfamily. These enzymes are also…”
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Peptides are better absorbed from the lung than the gut in the rat by HOOVER, J. L, RUSH, B. D, WILKINSON, K. F, DAY, J. S, BURTON, P. S, VIDMAR, T. J, RUWART, M. J

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Evaluation of a vitamin-cloaking strategy for oligopeptide therapeutics: biotinylated HIV-1 protease inhibitors by Islam, I, Ng, K. Y, Chong, K. T, McQuade, T. J, Hui, J. O, Wilkinson, K. F, Rush, B. D, Ruwart, M. J, Borchardt, R. T, Fisher, J. F

“…The outstanding limitations to the oligopeptide as a therapeutic agent are poor oral availability and rapid biliary clearance. To address these concerns a…”
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Intrapulmonary delivery of renin inhibitory peptides results in sustained release because of saturable transport by SHEEHY, A. M, HOOVER, J. L, RUSH, B. D, WILKINSON, K. F, VIDMAR, T. J, RUWART, M. J

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Desolvation energy : a major determinant of absorption, but not clearance, of peptides in rats by KARLS, M. S, RUSH, B. D, WILKINSON, K. F, VIDMAR, T. J, BURTON, P. S, RUWART, M. J

“…The oral delivery of peptidic drugs is problematic because of their degradation in the gastrointestinal tract and low absorption through the intestinal mucosa…”
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Clonidine delays small intestinal transit in the rat by Ruwart, M J, Klepper, M S, Rush, B D

“…Subcutaneous clonidine (0.01--1.0 mg/kg) was found to delay small intestinal transit but not gastric emptying in the unanesthetized rat, with a maximal effect…”
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Peptidomimetic HIV protease inhibitors: phosphate prodrugs with improved biological activities by Chong, Kong Teck, Ruwart, Mary J, Hinshaw, Roger R, Wilkinson, Karen F, Rush, Bob D, Yancey, Mark F, Strohbach, Joseph W, Thaisrivongs, Suvit

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Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses by Brideau, Roger J., Knechtel, Mary L., Huang, Audris, Vaillancourt, Valerie A., Vera, Ellen E., Oien, Nancee L., Hopkins, Todd A., Wieber, Janet L., Wilkinson, Karen F., Rush, Bob D., Schwende, Francis J., Wathen, Michael W.

“…We identified a novel class of 4-oxo-dihydroquinolines represented by PNU-183792 which specifically inhibit herpesvirus polymerases. PNU-183792 was highly…”
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16,16-Dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver by Ruwart, M J, Rush, B D, Snyder, K F, Peters, K M, Appelman, H D, Henley, K S

“…Chronic nutritional injury was induced in rats by a high-fat, lipotrope-deficient diet. The hepatoprotective effect of 16,16-dimethyl prostaglandin E2 on the…”
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16,16 Dimethyl prostaglandin E2 decreases the formation of collagen in fibrotic rat liver slices by Peters, K M, Snyder, K F, Rush, B D, Ruwart, M J, Henley, K S

“…The effect of 16,16 dimethyl prostaglandin E2 (DMPG) on fibrogenesis was studied in slices from normal and fibrotic rat liver. Rats received a cirrhogenic diet…”
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Peptide to glycopeptide: glycosylated oligopeptide renin inhibitors with attenuated in vivo clearance properties by Fisher, Jed F, Harrison, Allen W, Bundy, Gordon L, Wilkinson, Karen F, Rush, Bob D, Ruwart, Mary J

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Prazosin inhibits small intestinal transit in the rat by Rush, B.D., Ruwart, M.J.

“…Gastric emptying, small intestinal transit, and colonic transit were measured in fasted rats preimplanted with either duodenal or colonic cannulae. At the…”
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Development of activity assays for high-volume evaluation of human immunodeficiency virus (HIV) protease inhibitors in rat serum : results with ditekiren by WILKINSON, K. F, RUSH, B. D, SHARMA, S. K, EVANS, D. B, RUWART, M. J, FRIIS, J. M, BOHANON, M. J, TOMICH, P. K

“…We showed previously that a commercially available synthetic tetradecapeptide, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, produces authentic…”
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Hepatic protection by 16, 16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1-induced injury in the rat by Rush, B D, Wilkinson, K F, Nichols, N M, Ochoa, R, Brunden, M N, Ruwart, M J

“…Studies were conducted to assess the possible protective action of 16,16-dimethyl prostaglandin E2 (DMPG) against acute aflatoxin B1 (AFB1) induced hepatic…”
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16,16-Dimethyl PGE2 and fatty acids protect hepatocytes against CCL4-induced damage by RUWART, M. J, NICHOLS, N. M, HEDEEN, K, RUSH, B. D, STACHURA, J

“…16,16-Dimethyl PGE2 (dmPGE2) has previously been shown to protect the in vivo rat liver against CCl4-induced damage. These studies were undertaken to determine…”
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Prostacyclin inhibits gastric emptying and small-intestinal transit in rats and dogs by Ruwart, M J, Rush, B D

“…Prostacyclin (PGI2) antagonizes 16,16-dimethyl prostaglandin E2-induced diarrhea in rats, presumably by inhibiting the fluid accumulation of "enteropooling" in…”
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The role of accelerated colonic transit in prostaglandin‐induced diarrhoea and its inhibition by prostacyclin by Rush, Bob D., Ruwart, Mary J.

“…1 Rats treated with subcutaneous 16,16‐dimethyl prostaglandin E2 (16,16‐dimethyl PGE2, 100 μg kg−1) exhibited diarrhoea even when their ileo‐caecal junctions…”
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Timoprazole is a unique cytoprotective agent in the rat by Ruwart, M J, Nezamis, J E, Rush, B D, Lancaster, C, Davis, J P, Nichols, N M, Ochoa, R

“…Timoprazole, a substituted benzimidazole, is an antisecretory agent that inhibits gastric acid secretion by interference with (H+-K+)-ATPase. In the studies…”
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Development of a sensitive activity assay for high-volume evaluation of human renin inhibitory peptides in rat serum : results with U-71,038 by RUWART, M. J, SHARMA, S. K, JOHNSON, G. A, HARRIS, D. W, LAKINGS, D. B, RUSH, B. D, WILKINSON, K. F, CORNETTE, J. C, EVANS, D. B, FRIIS, J. M, COOK, K. J

“…A sensitive activity assay for high volume evaluation of human renin inhibitory peptides (RIPs) in rat sera (range 2-80 ng/ml) was developed based on the low…”
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