Search Results - "Rusconi, Christopher P."

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer by Ganson, Nancy J., PhD, Povsic, Thomas J., MD, Sullenger, Bruce A., PhD, Alexander, John H., MD, Zelenkofske, Steven L., DO, Sailstad, Jeffrey M., PhD, Rusconi, Christopher P., PhD, Hershfield, Michael S., MD

“…To the Editor: Nucleic acid aptamers are a novel class of drugs that can be selected to inhibit targets of interest, including protein-protein interactions.1…”
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Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer by Povsic, Thomas J., MD, PhD, Lawrence, Monica G., MD, Lincoff, A. Michael, MD, Mehran, Roxana, MD, Rusconi, Christopher P., PhD, Zelenkofske, Steven L., DO, Huang, Zhen, MS, Sailstad, Jeffrey, BS, Armstrong, Paul W., MD, Steg, P. Gabriel, MD, Bode, Christoph, MD, Becker, Richard C., MD, Alexander, John H., MD, MHS, Adkinson, N. Franklin, MD, Levinson, Arnold I., MD

“…Murine models of anaphylaxis have suggested that IgG antibody/allergen complexes interacting with Fcγ receptors on basophils and neutrophils release…”
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Aptamers: an emerging class of therapeutics by Nimjee, Shahid M, Rusconi, Christopher P, Sullenger, Bruce A

“…Numerous nucleic acid ligands, also termed decoys or aptamers, have been developed during the past 15 years that can inhibit the activity of many pathogenic…”
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Antidote-mediated control of an anticoagulant aptamer in vivo by Rusconi, Christopher P, Sullenger, Bruce A, Roberts, Joseph D, Pitoc, George A, Nimjee, Shahid M, White, Rebekah R, Quick, George, Scardino, Elizabeth, Fay, William P

“…Patient safety and treatment outcome could be improved if physicians could rapidly control the activity of therapeutic agents in their patients. Antidote…”
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First Clinical Application of an Actively Reversible Direct Factor IXa Inhibitor as an Anticoagulation Strategy in Patients Undergoing Percutaneous Coronary Intervention by COHEN, Mauricio G, PURDY, Drew A, ZELENKOFSKE, Steven, ALEXANDER, John H, HARRINGTON, Robert A, RUSCONI, Christopher P, BECKER, Richard C, ROSSI, Joseph S, GRINFELD, Liliana R, MYLES, Shelley K, ABERLE, Laura H, GREENBAUM, Adam B, FRY, Edward, CHAN, Mark Y, TONKENS, Ross M

“…The ideal anticoagulant should prevent ischemic complications without increasing the risk of bleeding. Controlled anticoagulation is possible with the REG1…”
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Coagulation Factor IXa as a Target for Treatment and Prophylaxis of Venous Thromboembolism by Eikelboom, John W, Zelenkofske, Steven L, Rusconi, Christopher P

“…Venous thromboembolism remains a frequent cause of vascular death. Despite advances in anticoagulant drug development, unmet needs remain, including limited…”
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Factor IXa Inhibitors as Novel Anticoagulants by Howard, Emily L, Becker, Kristian C.D, Rusconi, Christopher P, Becker, Richard C

“…Currently available anticoagulants are limited by modest therapeutic benefits, narrow clinical applications, increased bleeding risk, and drug-induced…”
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An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase by Buddai, Sai K., Layzer, Juliana M., Lu, Genmin, Rusconi, Christopher P., Sullenger, Bruce A., Monroe, Dougald M., Krishnaswamy, Sriram

“…The interaction of factor Xa with factor Va on membranes to form prothrombinase profoundly increases the rate of the proteolytic conversion of prothrombin to…”
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Inhibition of Rat Corneal Angiogenesis by a Nuclease-Resistant RNA Aptamer Specific for Angiopoietin-2 by White, Rebekah R., Shan, Siqing, Rusconi, Christopher P., Shetty, Geetha, Dewhirst, Mark W., Kontos, Christopher D., Sullenger, Bruce A.

“…Angiopoietin-2 (Ang2) appears to be a naturally occurring antagonist of the endothelial receptor tyrosine kinase Tie2, an important regulator of vascular…”
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A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: Design and rationale of the RADAR Phase IIb trial by Povsic, Thomas J., MD, PhD, Cohen, Mauricio G., MD, Mehran, Roxana, MD, Buller, Christopher E., MD, Bode, Christoph, MD, Cornel, Jan H., MD, Kasprzak, Jarosław D., MD, Montalescot, Gilles, MD, Joseph, Diane, Wargin, William A., PhD, Rusconi, Christopher P., PhD, Zelenkofske, Steven L., DO, Becker, Richard C., MD, Alexander, John H., MD, MHS

“…Anticoagulants are the cornerstone of current acute coronary syndrome (ACS) therapy; however, anticoagulation regimens that aggressively reduce ischemic events…”
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In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry by Tanaka, Kenichi A, Szlam, Fania, Rusconi, Christopher P, Levy, Jerrold H

“…The REG1 system consists of factor IXa inhibitor, RB006, an aptamer-based anticoagulant and its antidote, RB007. The optimal use of RB006 can be facilitated by…”
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To PEGylate or Not To PEGylate Therapeutics? by Maier, Keith E, Rusconi, Christopher P, Levy, Matthew

“…PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG…”
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First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology : A phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity by DYKE, Christopher K, STEINHUBL, Steven R, BECKER, Richard C, RUSCONI, Christopher P, KLEIMAN, Neal S, CANNON, Richard O, ABERLE, Laura G, MIN LIN, MYLES, Shelley K, MELLONI, Chiara, HARRINGTON, Robert A, ALEXANDER, John H

“…Selectivity, titratability, rapidity of onset, and active reversibility are desirable pharmacological properties of anticoagulant therapy administered for…”
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RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins by Jeter, Martha L, Ly, Linda V, Fortenberry, Yolanda M, Whinna, Herbert C, White, Rebekah R, Rusconi, Christopher P, Sullenger, Bruce A, Church, Frank C

“…We studied the RNA aptamer Toggle-25/thrombin interaction during inhibition by antithrombin (AT), heparin cofactor II (HCII) and protein C inhibitor (PCI)…”
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Phase 1b Randomized Study of Antidote-Controlled Modulation of Factor IXa Activity in Patients With Stable Coronary Artery Disease by CHAN, Mark Y, COHEN, Mauricio G, VORCHHEIMER, David A, CHRONOS, Nicholas, MELLONI, Chiara, ALEXANDER, John H, HARRINGTON, Robert A, TONKENS, Ross M, BECKER, Richard C, RUSCONI, Christopher P, DYKE, Christopher K, MYLES, Shelley K, ABERLE, Laura G, MIN LIN, WALDER, James, STEINHUBL, Steven R, GILCHRIST, Ian C, KLEIMAN, Neal S

“…Whether selective factor IXa inhibition produces an appropriate anticoagulant effect when combined with platelet-directed therapy in patients with stable…”
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Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes by Staudacher, Dawid L, Putz, Vera, Heger, Lukas, Reinöhl, Jochen, Hortmann, Marcus, Zelenkofske, Steven L, Becker, Richard C, Rusconi, Christopher P, Bode, Christoph, Ahrens, Ingo

“…Background: Residual platelet reactivity is a predictor of poor prognosis in patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary…”
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Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics by Becker, Richard C, Povsic, Thomas, Cohen, Mauricio G, Rusconi, Christopher P, Sullenger, Bruce

“…Antithrombotic therapy for the acute management of thrombotic disorders has been stimulated and guided actively by our current understanding of platelet…”
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Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy by Povsic, Thomas J., Wargin, William A., Alexander, John H., Krasnow, Joshua, Krolick, Merill, Cohen, Mauricio G., Mehran, Roxana, Buller, Christopher E., Bode, Christoph, Zelenkofske, Steven L., Rusconi, Christopher P., Becker, Richard C.

“…Aims Establishing factor IX inhibition in patients with acute coronary syndrome/non-ST-elevation myocardial infarction (ACS/NSTEMI), a setting characterized by…”
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The potential of aptamers as anticoagulants by Nimjee, Shahid M., Rusconi, Christopher P., Harrington, Robert A., Sullenger, Bruce A.

“…Useful additional options for anticoagulant therapy have been introduced over the last 15 years, including low-molecular-weight heparins and direct thrombin…”
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RNA aptamers as reversible antagonists of coagulation factor IXa by Rusconi, Christopher P, Sullenger, Bruce A, Scardino, Elizabeth, Layzer, Juliana, Pitoc, George A, Ortel, Thomas L, Monroe, Dougald

“…Many therapeutic agents are associated with adverse effects in patients. Anticoagulants can engender acute complications such as significant bleeding that…”
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