Search Results - "Rusciano, Dario"

Molecular Mechanisms and Therapeutic Potential of Gabapentin with a Focus on Topical Formulations to Treat Ocular Surface Diseases by Rusciano, Dario

“…Gabapentin (GBP) was originally developed as a potential agonist for Gamma-Amino-Butyric-Acid (GABA) receptors, aiming to inhibit the activation of…”
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The Therapeutic Trip of Melatonin Eye Drops: From the Ocular Surface to the Retina by Rusciano, Dario, Russo, Cristina

“…Melatonin is a ubiquitous molecule found in living organisms, ranging from bacteria to plants and mammals. It possesses various properties, partly due to its…”
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Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases by Rusciano, Dario, Bagnoli, Paola

“…In this review, we aim to provide an overview of the recent findings about the treatment of neovascular retinal diseases. The use of conventional drugs and…”
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Oxygen, the Paradox of Life and the Eye by Rusciano, Dario, Bagnoli, Paola

“…Oxidative stress, caused by the formation of free radicals, such as reactive oxygen species (ROS), leads to cell and tissue degradation, contributing to…”
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Autophagy in Diabetic Retinopathy by Rosa, Michelino Di, Distefano, Gisella, Gagliano, Caterina, Rusciano, Dario, Malaguarnera, Lucia

“…Autophagy is an important homeostatic cellular process encompassing a number of consecutive steps indispensable for degrading and recycling cytoplasmic…”
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Options for Topical Treatment of Oxidative Eye Diseases with a Special Focus on Retinopathies by Russo, Cristina, Rusciano, Dario, Santangelo, Rosa, Malaguarnera, Lucia

“…Antioxidants, usually administered orally through the systemic route, are known to counteract the harmful effects of oxidative stress on retinal cells. The…”
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Editorial: Eye Pain: Etiology and Therapeutic Approaches by Rusciano, Dario, Bagnoli, Paola, Gallar, Juana, Galor, Anat

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A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma by Cammalleri, Maurizio, Dal Monte, Massimo, Amato, Rosario, Bagnoli, Paola, Rusciano, Dario

“…There is indication that nutritional supplements protect retinal cells from degeneration. In a previous study, we demonstrated that dietary supplementation…”
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A Topical Formulation of Melatoninergic Compounds Exerts Strong Hypotensive and Neuroprotective Effects in a Rat Model of Hypertensive Glaucoma by Dal Monte, Massimo, Cammalleri, Maurizio, Amato, Rosario, Pezzino, Salvatore, Corsaro, Roberta, Bagnoli, Paola, Rusciano, Dario

“…Melatonin is of great importance for regulating several eye processes, including pressure homeostasis. Melatonin in combination with agomelatine has been…”
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Free amino acids: an innovative treatment for ocular surface disease by Rusciano, Dario, Roszkowska, Anna Maria, Gagliano, Caterina, Pezzino, Salvatore

“…Amino acids are the basic constituents of living organisms, and have both a structural and an active dynamic role in tissue and cell physiology. Human tears…”
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Structural Basis for Agonistic Activity and Selectivity toward Melatonin Receptors hMT1 and hMT2 by Cantarini, Mattia, Rusciano, Dario, Amato, Rosario, Canovai, Alessio, Cammalleri, Maurizio, Monte, Massimo Dal, Minnelli, Cristina, Laudadio, Emiliano, Mobbili, Giovanna, Giorgini, Giorgia, Galeazzi, Roberta

“…Glaucoma, a major ocular neuropathy originating from a progressive degeneration of retinal ganglion cells, is often associated with increased intraocular…”
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Effects of Topical Gabapentin on Ocular Pain and Tear Secretion by Cammalleri, Maurizio, Amato, Rosario, Olivieri, Melania, Pezzino, Salvatore, Bagnoli, Paola, Dal Monte, Massimo, Rusciano, Dario

“…Neuropathic ocular pain is a frequent occurrence in medium to severe dry eye disease (DED). Only palliative treatments, such as lubricants and…”
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Poly 2-methacryloyloxyethyl Phosphorylcholine Protects Corneal Cells and Contact Lenses from Desiccation Damage by Olivieri, Melania, Cristaldi, Martina, Pezzino, Salvatore, Spampinato, Giorgia, Corsaro, Roberta, Anfuso, Carmelina Daniela, Lupo, Gabriella, Rusciano, Dario

“…Contact lens (CL) wearing may cause discomfort and eye dryness. We describe here the efficacy of a synthetic polymer in protecting both the corneal epithelial…”
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Preventive Efficacy of an Antioxidant Compound on Blood Retinal Barrier Breakdown and Visual Dysfunction in Streptozotocin-Induced Diabetic Rats by Canovai, Alessio, Amato, Rosario, Melecchi, Alberto, Dal Monte, Massimo, Rusciano, Dario, Bagnoli, Paola, Cammalleri, Maurizio

“…In diabetic retinopathy (DR), high blood glucose drives chronic oxidative stress and inflammation that trigger alterations of the neurovascular balance finally…”
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Further Evidence on Efficacy of Diet Supplementation with Fatty Acids in Ocular Pathologies: Insights from the EAE Model of Optic Neuritis by Locri, Filippo, Cammalleri, Maurizio, Pini, Alessandro, Dal Monte, Massimo, Rusciano, Dario, Bagnoli, Paola

“…In the experimental autoimmune encephalomyelitis (EAE) mouse model of optic neuritis, we recently demonstrated that diet supplementation with a balanced…”
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Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma by Melecchi, Alberto, Amato, Rosario, Dal Monte, Massimo, Rusciano, Dario, Bagnoli, Paola, Cammalleri, Maurizio

“…Introduction Much interest has been addressed to antioxidant dietary supplements that are known to lower the risk of developing glaucoma or delay its…”
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Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation by Roszkowska, Anna M, Rusciano, Dario, Inferrera, Leandro, Severo, Alice Antonella, Aragona, Pasquale

“…Aim of this retrospective study was to estimate the effect of oral supplementation with amino acids (AA) on corneal nerves regrowth after excimer laser…”
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Increased efficacy of dietary supplement containing wax ester-rich marine oil and xanthophylls in a mouse model of dry macular degeneration by Melecchi, Alberto, Amato, Rosario, Lapi, Dominga, Dal Monte, Massimo, Rusciano, Dario, Bagnoli, Paola, Cammalleri, Maurizio

“…Age-related macular degeneration (AMD) is nowadays considered among the retinal diseases whose clinical management lacks established treatment approaches,…”
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Monoalkylated Epigallocatechin-3-gallate (C18-EGCG) as Novel Lipophilic EGCG Derivative: Characterization and Antioxidant Evaluation by Minnelli, Cristina, Galeazzi, Roberta, Laudadio, Emiliano, Amici, Adolfo, Rusciano, Dario, Armeni, Tatiana, Cantarini, Mattia, Stipa, Pierluigi, Mobbili, Giovanna

“…Epigallocatechin-3-gallate (EGCG) has the highest antioxidant activity compared to the others catechins of green tea. However, the beneficial effects are…”
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Comparative Efficiency of Lutein and Astaxanthin in the Protection of Human Corneal Epithelial Cells In Vitro from Blue-Violet Light Photo-Oxidative Damage by Cristaldi, Martina, Anfuso, Carmelina Daniela, Spampinato, Giorgia, Rusciano, Dario, Lupo, Gabriella

“…The aim of this study was to compare in vitro the protective and antioxidant properties of lutein and astaxanthin on human primary corneal epithelial cells…”
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