Search Results - "Rusch, Alfons"

Retardation of Cochlear Maturation and Impaired Hair Cell Function Caused by Deletion of All Known Thyroid Hormone Receptors by Rusch, Alfons, Ng, Lily, Goodyear, Richard, Oliver, Dominik, Lisoukov, Igor, Vennstrom, Bjorn, Richardson, Guy, Kelley, Matthew W, Forrest, Douglas

“…The deafness caused by early onset hypothyroidism indicates that thyroid hormone is essential for the development of hearing. We investigated the underlying…”
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Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish by Seiler, Christoph, Ben-David, Orit, Sidi, Samuel, Hendrich, Oliver, Rusch, Alfons, Burnside, Beth, Avraham, Karen B, Nicolson, Teresa

“…Unconventional myosins have been associated with hearing loss in humans, mice, and zebrafish. Mutations in myosin VI cause both recessive and dominant forms of…”
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Thyroid Hormone Receptor β -dependent Expression of a Potassium Conductance in Inner Hair Cells at the Onset of Hearing by Rusch, Alfons, Erway, Lawrence C., Oliver, Dominik, Vennstrom, Bjorn, Forrest, Douglas

“…To elucidate the role of thyroid hormone receptors (TRs) α 1 and β in the development of hearing, cochlear functions have been investigated in mice lacking TRα…”
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Sodium and calcium currents shape action potentials in immature mouse inner hair cells by Marcotti, Walter, Johnson, Stuart L., Rüsch, Alfons, Kros, Corné J.

“…Before the onset of hearing at postnatal day 12, mouse inner hair cells (IHCs) produce spontaneous and evoked action potentials. These spikes are likely to…”
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Expression of a potassium current in inner hair cells during development of hearing in mice by Kros, Corné J, Ruppersberg, J. Peter, Rüsch, Alfons

“…Excitable cells use ion channels to tailor their biophysical properties to the functional demands made upon them. During development, these demands may alter…”
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Postnatal Development of Type I and Type II Hair Cells in the Mouse Utricle: Acquisition of Voltage-Gated Conductances and Differentiated Morphology by Rusch, Alfons, Lysakowski, Anna, Eatock, Ruth Anne

“…The type I and type II hair cells of mature amniote vestibular organs have been classified according to their afferent nerve terminals: calyx and bouton,…”
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Expression of Ca2+-activated BK channel mRNA and its splice variants in the rat cochlea by Langer, Patricia, Gründer, Stefan, Rüsch, Alfons

“…Voltage‐activated K+ channels are important for shaping the receptor potentials of cochlear hair cells. In particular, the functional maturation of inner hair…”
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Genetic Analysis of Vertebrate Sensory Hair Cell Mechanosensation: the Zebrafish Circler Mutants by Nicolson, Teresa, Rüsch, Alfons, Friedrich, Rainer W, Granato, Michael, Ruppersberg, Johann Peter, Nüsslein-Volhard, Christiane

“…The molecular basis of sensory hair cell mechanotransduction is largely unknown. In order to identify genes that are essential for mechanosensory hair cell…”
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Deletion of the Ca2+-Activated Potassium (BK) α-Subunit but Not the BKβ1-Subunit Leads to Progressive Hearing Loss by Rüttiger, Lukas, Sausbier, Matthias, Zimmermann, Ulrike, Winter, Harald, Braig, Claudia, Engel, Jutta, Knirsch, Martina, Arntz, Claudia, Langer, Patricia, Hirt, Bernhard, Müller, Marcus, Köpschall, Iris, Pfister, Markus, Münkner, Stefan, Rohbock, Karin, Pfaff, Imke, Rüsch, Alfons, Ruth, Peter, Knipper, Marlies, Latorre, Ramon

“…The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of…”
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Hair cells in mammalian utricles by EATOCK, RUTH ANNE, RÜSCH, ALFONS, LYSAKOWSKI, ANNA, SAEKI, MAYUKO

“…Two morphological classes of mechanosensory cells have been described in the vestibular organs of mammals, birds, and reptiles: type I and type II hair cells…”
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Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor [alpha] gene by Ng, Lily, Rusch, Alfons, Amma, Lori L, Nordstrom, Kristina, Erway, Lawrence C, Vennstrom, Bjorn, rest, Douglas

“…Deletion of thyroid hormone receptor [beta] (TR[beta]), a ligand-dependent transcription factor encoded by the Thrb gene, causes deafness and thyroid…”
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Neurodevelopmental control by thyroid hormone receptors by Forrest, Douglas, Reh, Thomas A, Rüsch, Alfons

“…Recent studies have provided insights into the neurodevelopmental functions of thyroid hormone signaling. The nuclear thyroid hormone receptors (TRs) are…”
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Expression of Ca 2+ ‐activated BK channel mRNA and its splice variants in the rat cochlea by Langer, Patricia, Gründer, Stefan, Rüsch, Alfons

“…Abstract Voltage‐activated K + channels are important for shaping the receptor potentials of cochlear hair cells. In particular, the functional maturation of…”
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A delayed rectifier conductance in type I hair cells of the mouse utricle by Rüsch, A, Eatock, R A

“…1. Membrane currents of hair cells in acutely excised or cultured mouse utricles were recorded with the whole cell voltage-clamp method at temperatures between…”
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Mechano-electrical transduction in mice lacking the α-subunit of the epithelial sodium channel by Rüsch, Alfons, Hummler, Edith

“…Sensory hair cells of the vertebrate inner ear use mechanically gated transducer channels (MET) to perceive mechanical stimuli. The molecular nature of the MET…”
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Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor α gene by NG, Lily, RÜSCH, Alfons, AMMA, Lori L, NORDSTRÖM, Kristina, ERWAY, Lawrence C, VENNSTRÖM, Björn, FORREST, Douglas

“…Deletion of thyroid hormone receptor beta (TR beta), a ligand-dependent transcription factor encoded by the Thrb gene, causes deafness and thyroid…”
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Voltage responses of mouse utricular hair cells to injected currents by Rüsch, A, Eatock, R A

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Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss by Rüttiger, Lukas, Sausbier, Matthias, Zimmermann, Ulrike, Winter, Harald, Braig, Claudia, Engel, Jutta, Knirsch, Martina, Arntz, Claudia, Langer, Patricia, Hirt, Bernhard, Müller, Marcus, Köpschall, Iris, Pfister, Markus, Münkner, Stefan, Rohbock, Karin, Pfaff, Imke, Rüsch, Alfons, Ruth, Peter, Knipper, Marlies

“…The large conductance voltage- and Ca2+-activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of…”
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Deletion of the Ca 2 +-activated potassium (BK) α-subunit but not the BKβ1-subunit leads to progressive hearing loss by Rüttiger, Lukas, Sausbier, Matthias, Zimmermann, Ulrike, Winter, Harald, Braig, Claudia, Engel, Jutta, Knirsch, Martina, Arntz, Claudia, Langer, Patricia, Hirt, Bernhard, Müller, Marcus, Köpschall, Iris, Pfister, Markus, Münkner, Stefan, Rohbock, Karin, Pfaff, Imke, Rüsch, Alfons, Ruth, Peter, Knipper, Marlies

“…The large conductance voltage- and Ca 2+ -activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of…”
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Developmental changes in the physiology of hair cells by Eatock, Ruth Anne, Rüsch, Alfons

“…Mature hair cells express complements of ion channels which vary with hair cell type. Immature hair cells in the inner ears of neonatal mice and pre-hatch…”
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