Immobilization of carborane derivatives on Ni/Fe nanotubes for BNCT

Immobilization of carborane derivatives on Ni/Fe nanotubes for BNCT

The most important limitation for boron neutron capture therapy of cancer is the selective accumulation of boron compounds in tumor tissues in significant quantities. In this paper, we describe the possibility to use magnetic Ni/Fe nanotubes as carriers for boron delivery. Carborane derivatives cont...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology Vol. 20; no. 9; pp. 1 - 11
Main Authors: Korolkov, Ilya V., Kozlovskiy, Artem L., Gorin, Yevgeniy G., Kazantsev, Aleksander V., Shlimas, Dmitriy I., Zdorovets, Maxim V., Ualieva, Nazerke K., Rusakov, Viacheslav S.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-09-2018
Springer Nature B.V
Subjects:
Boron
Boron compounds
Cancer
Carborane
Characterization and Evaluation of Materials
Chemical composition
Chemistry and Materials Science
Derivatives
Fourier transforms
Immobilization
Inorganic Chemistry
Ionic interactions
Iron
Lasers
Magnetic properties
Materials Science
Morphology
Mossbauer spectroscopy
Nanoparticles
Nanotechnology
Nanotubes
Neutrons
Nickel
Nuclear capture
Optical Devices
Optics
Organic chemistry
Photonics
Physical Chemistry
Research Paper
Spectroscopy
Spectrum analysis
Therapy
Targeted delivery of drugs
Fe/Ni nanotubes
BNCT
Carborane
Magnetic nanostructures
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Summary:The most important limitation for boron neutron capture therapy of cancer is the selective accumulation of boron compounds in tumor tissues in significant quantities. In this paper, we describe the possibility to use magnetic Ni/Fe nanotubes as carriers for boron delivery. Carborane derivatives containing 10 and 21 boron atoms per molecule were immobilized on Ni/Fe nanotubes by covalent and ionic interactions. Magnetic properties of NTs were investigated by Mössbauer spectroscopy. Structure, element, chemical composition, and morphology of obtained magnetic nanotubes were studied by XRD, SEM-EDA, and FTIR spectroscopy. Results indicate success immobilization of carborane derivatives on Ni/Fe nanotubes and great potential to use them as carriers for boron neutron cancer therapy of cancer. Graphical abstract ᅟ
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-018-4346-8