Search Results - "Ruprecht, Verena"
-
1
The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
Published in Science (American Association for the Advancement of Science) (16-10-2020)“…The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical…”
Get full text
Journal Article -
2
Cortical Contractility Triggers a Stochastic Switch to Fast Amoeboid Cell Motility
Published in Cell (12-02-2015)“…3D amoeboid cell migration is central to many developmental and disease-related processes such as cancer metastasis. Here, we identify a unique prototypic…”
Get full text
Journal Article -
3
How cells respond to environmental cues - insights from bio-functionalized substrates
Published in Journal of cell science (01-01-2017)“…Biomimetic materials have long been the (he)art of bioengineering. They usually aim at mimicking in vivo conditions to allow in vitro culture, differentiation…”
Get full text
Journal Article -
4
Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence
Published in Cell (09-04-2015)“…Cell movement has essential functions in development, immunity, and cancer. Various cell migration patterns have been reported, but no general rule has emerged…”
Get full text
Journal Article -
5
Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation
Published in Cell reports (Cambridge) (19-07-2016)“…During metazoan development, the temporal pattern of morphogen signaling is critical for organizing cell fates in space and time. Yet, tools for temporally…”
Get full text
Journal Article -
6
Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11
Published in Nature communications (21-11-2022)“…Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show that polyglutamylation, a still…”
Get full text
Journal Article -
7
Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells
Published in Nature communications (18-04-2024)“…Colorectal cancer (CRC) tumors are composed of heterogeneous and plastic cell populations, including a pool of cancer stem cells that express LGR5. Whether…”
Get full text
Journal Article -
8
A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs
Published in Science advances (13-03-2020)“…Through the asymmetric distribution of messenger RNAs (mRNAs), cells spatially regulate gene expression to create cytoplasmic domains with specialized…”
Get full text
Journal Article -
9
TANGO1 inhibitors reduce collagen secretion and limit tissue scarring
Published in Nature communications (24-04-2024)“…Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread…”
Get full text
Journal Article -
10
Volumetric imaging of fast cellular dynamics with deep learning enhanced bioluminescence microscopy
Published in Communications biology (03-12-2022)“…Bioluminescence microscopy is an appealing alternative to fluorescence microscopy, because it does not depend on external illumination, and consequently does…”
Get full text
Journal Article -
11
Cell scientist to watch – Verena Ruprecht
Published in Journal of cell science (01-07-2021)“…ABSTRACT Verena Ruprecht received her PhD in Biophysics from the Johannes Kepler University in 2010 for her work on developing single-molecule super-resolution…”
Get full text
Journal Article -
12
What can we learn from single molecule trajectories?
Published in Current protein & peptide science (01-12-2011)“…Diffusing membrane constituents are constantly exposed to a variety of forces that influence their stochastic path. Single molecule experiments allow for…”
Get more information
Journal Article -
13
SIMPLE: Structured illumination based point localization estimator with enhanced precision
Published in Optics express (19-08-2019)“…We present a structured illumination microscopy based point localization estimator (SIMPLE) that achieves a 2-fold increase in single molecule localization…”
Get full text
Journal Article -
14
Modulation-enhanced localization microscopy
Published in JPhys photonics (01-10-2020)“…Super-resolution fluorescence microscopy has become a powerful tool in cell biology to observe sub-cellular organization and molecular details below the…”
Get full text
Journal Article -
15
The nucleus as a mechanosensitive controller of cell behavior
Published in Biophysical journal (11-02-2022)Get full text
Journal Article -
16
Cooperative epithelial phagocytosis enables error correction in the early embryo
Published in Nature (London) (25-02-2021)“…Errors in early embryogenesis are a cause of sporadic cell death and developmental failure 1 , 2 . Phagocytic activity has a central role in scavenging…”
Get full text
Journal Article -
17
Friction forces position the neural anlage
Published in Nature cell biology (01-04-2017)“…During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early…”
Get full text
Journal Article -
18
Specialization of the photoreceptor transcriptome by Srrm3 -dependent microexons is required for outer segment maintenance and vision
Published in Proceedings of the National Academy of Sciences - PNAS (19-07-2022)“…Retinal photoreceptors have a distinct transcriptomic profile compared to other neuronal subtypes, likely reflecting their unique cellular morphology and…”
Get full text
Journal Article -
19
Imaging of Mobile Long-lived Nanoplatforms in the Live Cell Plasma Membrane
Published in The Journal of biological chemistry (31-12-2010)“…The plasma membrane has been hypothesized to contain nanoscopic lipid platforms, which are discussed in the context of “lipid rafts” or “membrane rafts.” Based…”
Get full text
Journal Article -
20
Actin Retrograde Flows Stabilize Cell Polarity by Mechano-Chemical Feedback Loops in Migrating Cells
Published in Biophysical journal (16-02-2016)Get full text
Journal Article