Search Results - "Ruppel, M."

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations by Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A

“…A working model for β-cardiac myosin in the sequestered state and binding assays reveal interactions between the myosin head and tail that are disrupted by…”
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Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy by Ranjbarvaziri, Sara, Kooiker, Kristina B., Ellenberger, Mathew, Fajardo, Giovanni, Zhao, Mingming, Vander Roest, Alison Schroer, Woldeyes, Rahel A., Koyano, Tiffany T., Fong, Robyn, Ma, Ning, Tian, Lei, Traber, Gavin M., Chan, Frandics, Perrino, John, Reddy, Sushma, Chiu, Wah, Wu, Joseph C., Woo, Joseph Y., Ruppel, Kathleen M., Spudich, James A., Snyder, Michael P., Contrepois, Kévin, Bernstein, Daniel

“…Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the…”
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Hypertrophic cardiomyopathy: Mutations to mechanisms to therapies by Kawana, Masataka, Spudich, James A, Ruppel, Kathleen M

“…Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general population with an extensive burden of morbidity in the form of arrhythmia,…”
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β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity by Adhikari, Arjun S., Trivedi, Darshan V., Sarkar, Saswata S., Song, Dan, Kooiker, Kristina B., Bernstein, Daniel, Spudich, James A., Ruppel, Kathleen M.

“…Hypertrophic cardiomyopathy (HCM) affects 1 in 500 people and leads to hyper-contractility of the heart. Nearly 40 percent of HCM-causing mutations are found…”
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Cryo-EM structure of the folded-back state of human β-cardiac myosin by Grinzato, Alessandro, Auguin, Daniel, Kikuti, Carlos, Nandwani, Neha, Moussaoui, Dihia, Pathak, Divya, Kandiah, Eaazhisai, Ruppel, Kathleen M., Spudich, James A., Houdusse, Anne, Robert-Paganin, Julien

“…To save energy and precisely regulate cardiac contractility, cardiac muscle myosin heads are sequestered in an ‘off’ state that can be converted to an ‘on’…”
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Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector by Aksel, Tural, Choe Yu, Elizabeth, Sutton, Shirley, Ruppel, Kathleen M., Spudich, James A.

“…Cardiomyopathies due to mutations in human β-cardiac myosin are a significant cause of heart failure, sudden death, and arrhythmia. To understand the…”
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Direct aerosol chemical composition measurements to evaluate the physicochemical differences between controlled sea spray aerosol generation schemes by Collins, D. B, Zhao, D. F, Ruppel, M. J, Laskina, O, Grandquist, J. R, Modini, R. L, Stokes, M. D, Russell, L. M, Bertram, T. H, Grassian, V. H, Deane, G. B, Prather, K. A

“…Controlled laboratory studies of the physical and chemical properties of sea spray aerosol (SSA) must be under-pinned by a physically and chemically accurate…”
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Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light by Trivedi, Darshan V., Adhikari, Arjun S., Sarkar, Saswata S., Ruppel, Kathleen M., Spudich, James A.

“…The sarcomere is an exquisitely designed apparatus that is capable of generating force, which in the case of the heart results in the pumping of blood…”
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A Marine Aerosol Reference Tank system as a breaking wave analogue for the production of foam and sea-spray aerosols by Stokes, M. D, Deane, G. B, Prather, K, Bertram, T. H, Ruppel, M. J, Ryder, O. S, Brady, J. M, Zhao, D

“…In order to better understand the processes governing the production of marine aerosols a repeatable, controlled method for their generation is required. The…”
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Increase in elemental carbon values between 1970 and 2004 observed in a 300-year ice core from Holtedahlfonna (Svalbard) by Ruppel, M. M, Isaksson, E, Ström, J, Beaudon, E, Svensson, J, Pedersen, C. A, Korhola, A

“…Black carbon (BC) is a light-absorbing particle that warms the atmosphere–Earth system. The climate effects of BC are amplified in the Arctic, where its…”
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The effect of the microscopic and nanoscale structure on bone fragility by Ruppel, M. E., Miller, L. M., Burr, D. B.

“…Summary Bone mineral density is the gold-standard for assessing bone quantity and diagnosing osteoporosis. Although bone mineral density measurements assess…”
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Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function by Morck, Makenna M, Bhowmik, Debanjan, Pathak, Divya, Dawood, Aminah, Spudich, James, Ruppel, Kathleen M

“…Mutations in the lever arm of β-cardiac myosin are a frequent cause of hypertrophic cardiomyopathy, a disease characterized by hypercontractility and eventual…”
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Do contemporary (1980–2015) emissions determine the elemental carbon deposition trend at Holtedahlfonna glacier, Svalbard? by Ruppel, Meri M, Soares, Joana, Gallet, Jean-Charles, Isaksson, Elisabeth, Martma, Tonu, Svensson, Jonas, Kohler, Jack, Pedersen, Christina A, Manninen, Sirkku, Korhola, Atte, Strom, Johan

“…The climate impact of black carbon (BC) is notably amplified in the Arctic by its deposition, which causes albedo decrease and subsequent earlier snow and ice…”
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Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin by Sommese, Ruth F, Nag, Suman, Sutton, Shirley, Miller, Susan M, Spudich, James A, Ruppel, Kathleen M

“…Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) lead to significant cardiovascular morbidity and mortality worldwide. Mutations in the genes…”
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The complex composition of organic aerosols emitted during burning varies between Arctic and boreal peat by Schneider, Eric, Rüger, Christopher P., Chacón-Patiño, Martha L., Somero, Markus, Ruppel, Meri M., Ihalainen, Mika, Köster, Kajar, Sippula, Olli, Czech, Hendryk, Zimmermann, Ralf

“…Abstract Peatlands in the northern hemisphere are a major carbon storage but face an increased risk of wildfires due to climate change leading to large-scale…”
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Climatic impacts on an Arctic lake since 1300 AD: a multi-proxy lake sediment reconstruction from Prins Karls Forland, Svalbard by Orme, L. C., Lind, E. M., Holm, T. M., Kjellman, S. E., Koinig, K. A., Hormes, A., Rosqvist, G. C., Ruppel, M., Divine, D. V., Husum, K., Miettinen, A., Isaksson, E.

“…On the remote Arctic archipelago of Svalbard, there is increasing evidence of environmental impacts from climate change. The analysis of lake sedimentary…”
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Polystyrene nanoparticles with tunable interfaces and softness by HOLLEY, D. W, RUPPEL, M, MAYS, J. W, URBAN, V. S, BASKARAN, D

“…Polystyrene nanoparticles, cross-linked with divinylbenzene (PS-(DVB) sub(x)) and having radii, R sub(p) [< or =] 10 nm, have been synthesized using batch and…”
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Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming by deCamp, Allan C., Corcoran, Martin M., Fulp, William J., Willis, Jordan R., Cottrell, Christopher A., Bader, Daniel L. V., Kalyuzhniy, Oleksandr, Leggat, David J., Cohen, Kristen W., Hyrien, Ollivier, Menis, Sergey, Finak, Greg, Ballweber-Fleming, Lamar, Srikanth, Abhinaya, Plyler, Jason R., Rahaman, Farhad, Lombardo, Angela, Philiponis, Vincent, Whaley, Rachael E., Seese, Aaron, Brand, Joshua, Ruppel, Alexis M., Hoyland, Wesley, Mahoney, Celia R., Cagigi, Alberto, Taylor, Alison, Brown, David M., Ambrozak, David R., Sincomb, Troy, Mullen, Tina-Marie, Maenza, Janine, Kolokythas, Orpheus, Khati, Nadia, Bethony, Jeffrey, Roederer, Mario, Diemert, David, Koup, Richard A., Laufer, Dagna S., McElrath, Juliana M., McDermott, Adrian B., Karlsson Hedestam, Gunilla B., Schief, William R.

“…Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines…”
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Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level by Liu, Chao, Kawana, Masataka, Song, Dan, Ruppel, Kathleen M., Spudich, James A.

“…Concepts in molecular tension sensing in biology are growing and have their origins in studies of muscle contraction. In the heart muscle, a key parameter of…”
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Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers by Anderson, Robert L., Trivedi, Darshan V., Sarkar, Saswata S., Henze, Marcus, Ma, Weikang, Gong, Henry, Rogers, Christopher S., Gorham, Joshua M., Wong, Fiona L., Morck, Makenna M., Seidman, Jonathan G., Ruppel, Kathleen M., Irving, Thomas C., Cooke, Roger, Green, Eric M., Spudich, James A.

“…Mutations in β-cardiac myosin, the predominant motor protein for human heart contraction, can alter power output and cause cardiomyopathy. However,…”
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