Search Results - "Ruparelia, Ketan C"

CYP1-Activation and Anticancer Properties of Synthetic Methoxylated Resveratrol Analogues by Ruparelia, Ketan C, Zeka, Keti, Beresford, Kenneth J M, Wilsher, Nicola E, Potter, Gerry A, Androutsopoulos, Vasilis P, Brucoli, Federico, Arroo, Randolph R J

“…Naturally occurring stilbenoids, such as the ( )-stilbenoid resveratrol and the ( )-stilbenoid combretastatin A4, have been considered as promising lead…”
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Activity of Antioxidants from Crocus sativus L. Petals: Potential Preventive Effects towards Cardiovascular System by Zeka, Keti, Marrazzo, Pasquale, Micucci, Matteo, Ruparelia, Ketan C., Arroo, Randolph R. J., Macchiarelli, Guido, Annarita Nottola, Stefania, Continenza, Maria Adelaide, Chiarini, Alberto, Angeloni, Cristina, Hrelia, Silvana, Budriesi, Roberta

“…The petals of the saffron crocus (Crocus sativus L.) are considered a waste material in saffron production, but may be a sustainable source of natural…”
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Flavones as tyrosinase inhibitors: kinetic studies in vitro and in silico by Arroo, Randolph R.J., Sari, Suat, Barut, Burak, Özel, Arzu, Ruparelia, Ketan C., Şöhretoğlu, Didem

“…Introduction Tyrosinase is a multifunctional copper‐containing oxidase enzyme that catalyses the first steps in the formation of melanin pigments…”
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Signal transduction of the insulin secretion induced by the chalcone analogue, (E)-3-(phenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one, and its role in glucose and lipid metabolism by Sulis, Paola Miranda, Bittencourt Mendes, Ana Karla, Fernandes, Thaís Alves, Frederico, Marisa Jadna Silva, Rey, Diana Patricia, Aragón, Marcela, Ruparelia, Ketan C., Silva, Fátima Regina Mena Barreto

“…A chalcone analogue, (E)-3-(phenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (DMU 101), was synthesized using classic base catalysis and Claisen-Schmidt…”
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Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines by Horley, Neill J., Beresford, Kenneth J.M., Chawla, Tarun, McCann, Glen J.P., Ruparelia, Ketan C., Gatchie, Linda, Sonawane, Vinay R., Williams, Ibidapo S., Tan, Hoon L., Joshi, Prashant, Bharate, Sonali S., Kumar, Vikas, Bharate, Sandip B., Chaudhuri, Bhabatosh

“…The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k…”
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Anticancer effects of the metabolic products of the resveratrol analogue, DMU-212: Structural requirements for potency by Androutsopoulos, Vasilis P., Ruparelia, Ketan C., Papakyriakou, Athanasios, Filippakis, Harilaos, Tsatsakis, Aristeidis M., Spandidos, Demetrios A.

“…The methoxylated trans-stilbene resveratrol analogue, (E)-3,4,5,4′-tetramethoxystilbene (1), has shown promising antiproliferative activity in in vitro cell…”
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The synthesis of 4,6-diaryl-2-pyridones and their bioactivation in CYP1 expressing breast cancer cells by Ruparelia, Ketan C., Lodhi, Sabahat, Ankrett, Dyan N., Wilsher, Nicola E., Arroo, Randolph R.J., Potter, Gerard A., Beresford, Kenneth J.M.

“…[Display omitted] As part of a programme to develop anticancer prodrugs which are activated by cytochrome P450 (CYP)1B1, a library of 4,6-diaryl-2-pyridones…”
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(E)-3-(3,4,5-Trimethoxyphenyl)-1-(pyridin-4-yl)prop-2-en-1-one, a heterocyclic chalcone is a potent and selective CYP1A1 inhibitor and cancer chemopreventive agent by Horley, Neill J., Beresford, Kenneth J.M., Kaduskar, Supriya, Joshi, Prashant, McCann, Glen J.P., Ruparelia, Ketan C., Williams, Ibidapo S., Gatchie, Linda, Sonawane, Vinay R., Bharate, Sandip B., Chaudhuri, Bhabatosh

“…[Display omitted] The overexpression of CYP1 family of enzymes is reported to be associated with development of human carcinomas. It has been well reported…”
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Analysis of plant secondary metabolism using stable isotope‐labelled precursors by Arroo, Randolph R.J., Bhambra, Avninder S., Hano, Christophe, Renda, Gülin, Ruparelia, Ketan C., Wang, Meng F.

“…Introduction Analysis of biochemical pathways typically involves feeding a labelled precursor to an organism, and then monitoring the metabolic fate of the…”
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Synthesis and antitrypanosomal activities of novel pyridylchalcones by Bhambra, Avninder S., Ruparelia, Ketan C., Tan, Hoon L., Tasdemir, Deniz, Burrell-Saward, Hollie, Yardley, Vanessa, Beresford, Kenneth J.M., Arroo, Randolph R.J.

“…A library of novel pyridylchalcones were synthesised and screened against Trypanosoma brucei rhodesiense. Eight were shown to have good activity with the most…”
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Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) on adenoma development in the Apc(Min+) mouse and cyclooxygenase-2 in human-derived colon cancer cells by Sale, Stewart, Tunstall, Richard G, Ruparelia, Ketan C, Potter, Gerry A, Steward, William P, Gescher, Andreas J

“…Naturally occurring molecules with putative cancer chemopreventive properties such as the phytoalexin resveratrol (3,5,4'-trihydroxystilbene) are lead…”
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Phytoestrogens as natural prodrugs in cancer prevention: towards a mechanistic model by Arroo, Randolph R. J, Beresford, Kenneth, Bhambra, Avninder S, Boarder, Mike, Budriesi, Roberta, Cheng, Zhong, Micucci, Matteo, Ruparelia, Ketan C, Surichan, Somchaiya, Androutsopoulos, Vasilis P

“…It has been widely acknowledged that regular consumption of fresh fruits and vegetables is linked with a relatively low incidence of cancers (e.g. breast,…”
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Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol by Zeka, Keti, Ruparelia, Ketan C., Continenza, Maria A., Stagos, Dimitrios, Vegliò, Francesco, Arroo, Randolph R.J.

“…Saffron from the province of L'Aquila, in the Abruzzo region of Italy, is highly prized and has been awarded a formal recognition by the European Union with EU…”
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Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4′‐tetramethoxystilbene (DMU‐212) on adenoma development in the ApcMin+ mouse and cyclooxygenase‐2 in human‐derived colon cancer cells by Sale, Stewart, Tunstall, Richard G., Ruparelia, Ketan C., Potter, Gerry A., Steward, William P., Gescher, Andreas J.

“…Naturally occurring molecules with putative cancer chemopreventive properties such as the phytoalexin resveratrol (3,5,4′‐trihydroxystilbene) are lead…”
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Synthesis and Biological Evaluation of Novel Chloroethylaminoanthraquinones with Potent Cytotoxic Activity against Cisplatin-Resistant Tumor Cells by Pors, Klaus, Paniwnyk, Zennia, Ruparelia, Ketan C, Teesdale-Spittle, Paul H, Hartley, John A, Kelland, Lloyd R, Patterson, Laurence H

“…Novel 1- and 1,4-substituted chloroethylaminoanthraquinones with DNA binding and alkylating properties along with their respective…”
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Anthraquinone-peptides as inhibitors of AP-1 transcription factor by IJAZ, Taeeba, PHOUNG TRAN, RUPARELIA, Ketan C, TEESDALE-SPITTLE, Paul H, ORR, Samantha, PATTERSON, Laurence H

“…Peptide-1-[N-[2-succinamidylethyl]amino]anthraquinones containing five seven amino acid residues including the KCR motif important in AP-1 protein binding to…”
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Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4′‐tetramethoxystilbene (DMU‐212) on adenoma development in the Apc Min+ mouse and cyclooxygenase‐2 in human‐derived colon cancer cells by Sale, Stewart, Tunstall, Richard G., Ruparelia, Ketan C., Potter, Gerry A., Steward, William P., Gescher, Andreas J.

“…Abstract Naturally occurring molecules with putative cancer chemopreventive properties such as the phytoalexin resveratrol (3,5,4′‐trihydroxystilbene) are lead…”
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