Search Results - "Runyon, Scott P."

Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery by Narayanan, Sanju, Harris, Danni L, Maitra, Rangan, Runyon, Scott P

“…Apelin peptides and the apelin receptor represent a relatively new therapeutic axis for the potential treatment of cardiovascular disease. Several reports…”
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The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor by Perrey, David A., Decker, Ann M., Li, Jun-Xu, Gilmour, Brian P., Thomas, Brian F., Harris, Danni L., Runyon, Scott P., Zhang, Yanan

“…[Display omitted] Selective antagonism of the orexin 1 (OX1) receptor has been proposed as a potential mechanism for treatment of drug addiction. We have…”
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Effect of 1‑Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin‑1 Receptor by Perrey, David A, German, Nadezhda A, Decker, Ann M, Thorn, David, Li, Jun-Xu, Gilmour, Brian P, Thomas, Brian F, Harris, Danni L, Runyon, Scott P, Zhang, Yanan

“…Selective blockade of the orexin-1 receptor (OX1) has been suggested as a potential approach to drug addiction therapy because of its role in modulating the…”
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Identification of potent pyrazole based APELIN receptor (APJ) agonists by Narayanan, Sanju, Vasukuttan, Vineetha, Rajagopal, Sudarshan, Maitra, Rangan, Runyon, Scott P.

“…[Display omitted] The apelinergic system comprises the apelin receptor and its cognate apelin and elabela peptide ligands of various lengths. This system has…”
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Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor by Narayanan, Sanju, Dai, Donghua, Vyas Devambatla, Ravi Kumar, Albert, Vincent, Bruneau-Latour, Nicolas, Vasukuttan, Vineetha, Ciblat, Stephane, Rehder, Kenneth, Runyon, Scott P., Maitra, Rangan

“…[Display omitted] The apelin receptor (APJ) is a target for cardiovascular indications. Previously, we had identified a novel pyrazole-based agonist 1…”
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Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice by Narayanan, Sanju, Wang, Shaobin, Vasukuttan, Vineetha, Vyas Devambatla, Ravi Kumar, Dai, Donghua, Jin, Chunyang, Snyder, Rodney, Laudermilk, Lucas, Runyon, Scott P, Maitra, Rangan

“…Apelin receptor agonism improves symptoms of metabolic syndrome. However, endogenous apelin peptides have short half-lives, making their utility as potential…”
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RTI-263, a biased neuropeptide S receptor agonist that retains an anxiolytic effect, attenuates cocaine-seeking behavior in rats by Huang, Yuanli, Wojciechowski, Alaina, Feldman, Kyle, Ettaro, Robert, Veros, Kaliana, Ritter, Morgan, Costa, Paula, DiStasio, Jacob, Peirick, Jennifer J., Reissner, Kathryn J., Runyon, Scott P., Clark, Stewart D.

“…Neuropeptide S (NPS) is a neuromodulatory peptide that acts via a G protein-coupled receptor. Centrally administered NPS suppresses anxiety-like behaviors in…”
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Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor by Amato, George S, Manke, Amruta, Harris, Danni L, Wiethe, Robert W, Vasukuttan, Vineetha, Snyder, Rodney W, Lefever, Timothy W, Cortes, Ricardo, Zhang, Yanan, Wang, Shaobin, Runyon, Scott P, Maitra, Rangan

“…Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome, and dyslipidemias…”
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Identifying structural determinants of potency for analogs of apelin-13: Integration of C-terminal truncation with structure–activity by Zhang, Yanyan, Maitra, Rangan, Harris, Danni L., Dhungana, Suraj, Snyder, Rodney, Runyon, Scott P.

“…Apelin peptides function as endogenous ligands of the APJ receptor and have been implicated in a number of important biological processes. While several…”
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Preclinical Efficacy and Selectivity of Vaccines Targeting Fentanyl, Alfentanil, Sufentanil, and Acetylfentanyl in Rats by Baehr, Carly, Robinson, Christine, Kassick, Andrew, Jahan, Rajwana, Gradinati, Valeria, Averick, Saadyah E., Runyon, Scott P., Pravetoni, Marco

“…The ongoing public health emergency of opioid use disorders (OUD) and overdose in the United States is largely driven by fentanyl and its related analogues and…”
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Discovery of a novel small molecule agonist scaffold for the APJ receptor by Narayanan, Sanju, Maitra, Rangan, Deschamps, Jeffery R., Bortoff, Katherine, Thomas, James B., Zhang, Yanyan, Warner, Keith, Vasukuttan, Vineetha, Decker, Ann, Runyon, Scott P.

“…[Display omitted] The apelinergic system includes a series of endogenous peptides apelin, ELABELA/TODDLER and their 7-transmembrane G-protein coupled apelin…”
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Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation by Clark, Stewart D., Kenakin, Terrence P., Gertz, Steven, Hassler, Carla, Gay, Elaine A., Langston, Tiffany L., Reinscheid, Rainer K., Runyon, Scott P.

“…The neuropeptide S system has been implicated in a number of centrally mediated behaviors including memory consolidation, anxiolysis, and increased locomotor…”
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Anti-Müllerian hormone as a biomarker for acute testicular degeneration caused by toxic insults to stallion testes by Pozor, Malgorzata, Conley, Alan J., Roser, Janet F., Nolin, Maggie, Zambrano, Gina L., Runyon, Scott P., Kelleman, Audrey A., Macpherson, Margo L.

“…Recently, anti-Müllerian hormone (AMH) was validated as a reliable marker of testicular damage caused by various chemotherapy drugs in humans and in mice. In…”
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Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery: Miniperspective by Narayanan, Sanju, Harris, Danni L, Maitra, Rangan, Runyon, Scott P

“…Apelin peptides and the apelin receptor represent a relatively new therapeutic axis for the potential treatment of cardiovascular disease. Several reports…”
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Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)‑7-Hydroxy‑N‑[(1S)‑2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic) by Ondachi, Pauline W, Kormos, Chad M, Runyon, Scott P, Thomas, James B, Mascarella, S. Wayne, Decker, Ann M, Navarro, Hernán A, Fennell, Timothy R, Snyder, Rodney W, Carroll, F. Ivy

“…Past studies have shown that it has been difficult to discover and develop potent and selective κ opioid receptor antagonists, particularly compounds having…”
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Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists by Amato, George S., Manke, Amruta, Vasukuttan, Vineetha, Wiethe, Robert W., Snyder, Rodney W., Runyon, Scott P., Maitra, Rangan

“…[Display omitted] Antagonists of peripheral type 1 cannabinoid receptors (CB1) may have utility in the treatment of obesity, liver disease, metabolic syndrome…”
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Antagonism of the neuropeptide S receptor with RTI-118 decreases cocaine self-administration and cocaine-seeking behavior in rats by Schmoutz, Christopher D., Zhang, Yanan, Runyon, Scott P., Goeders, Nicholas E.

“…Neuropeptide S (NPS) is a neuromodulatory peptide, acting via a G-protein-coupled receptor to regulate sleep, anxiety and behavioral arousal. Recent research…”
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Effects of inhibitory GABA-active neurosteroids on cocaine seeking and cocaine taking in rats by Schmoutz, Christopher D., Runyon, Scott P, Goeders, Nicholas E.

“…Rationale Several compounds that potentiate GABA-induced inhibitory currents also decrease stress, anxiety and addiction-related behaviors. Because of the…”
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A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats by Schmoutz, Christopher D., Guerin, Glenn F., Runyon, Scott P., Dhungana, Suraj, Goeders, Nicholas E.

“…•Combination of metyrapone and oxazepam (MET/OX) decreases drug self-administration.•MET/OX treatment increases neurosteroid levels in rat brain…”
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Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)‑N‑[1R)‑1-(Cyclohexylmethyl)-2-methylpropyl]-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (CDTic by Kormos, Chad M, Ondachi, Pauline W, Runyon, Scott P, Thomas, James B, Mascarella, S. Wayne, Decker, Ann M, Navarro, Hernán A, Fennell, Timothy R, Snyder, Rodney W, Carroll, F. Ivy

“…Animal pharmacological studies suggest that potent and selective κ opioid receptor antagonists have potential as pharmacotherapies targeting depression,…”
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