Search Results - "Runnels, Loren W"

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development by Willekens, Jeremy, Runnels, Loren W

“…The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn flexible chemistry allows it to regulate the activity of hundreds of…”
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CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells by Bai, Zhiyong, Feng, Jianlin, Franken, Gijs A C, Al'Saadi, Namariq, Cai, Na, Yu, Albert S, Lou, Liping, Komiya, Yuko, Hoenderop, Joost G J, de Baaij, Jeroen H F, Yue, Lixia, Runnels, Loren W

“…Magnesium is essential for cellular life, but how it is homeostatically controlled still remains poorly understood. Here, we report that members of CNNM…”
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TRPM6 and TRPM7: A Mul-TRP-PLIK-cation of channel functions by Runnels, Loren W

“…Unique among ion channels, TRPM6 and TRPM7 garnered much interest upon their discovery as the first ion channels to possess their own kinase domain. Soon after…”
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TRPM7 regulates polarized cell movements by Su, Li-Ting, Liu, Wei, Chen, Hsiang-Chin, González-Pagán, Omayra, Habas, Raymond, Runnels, Loren W

“…TRPM7 (transient receptor potential melastatin 7) is a Ca²+- and Mg²+-permeant ion channel in possession of its own kinase domain. As a kinase, the protein has…”
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Molecular Determinants of Mg2+ and Ca2+ Permeability and pH Sensitivity in TRPM6 and TRPM7 by Li, Mingjiang, Du, Jianyang, Jiang, Jianmin, Ratzan, William, Su, Li-Ting, Runnels, Loren W., Yue, Lixia

“…The channel kinases TRPM6 and TRPM7 have recently been discovered to play important roles in Mg2+ and Ca2+ homeostasis, which is critical to both human health…”
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Mechanism of activation of the Formin protein Daam1 by Liu, Wei, Sato, Akira, Khadka, Deepak, Bharti, Ritu, Diaz, Hector, Runnels, Loren W, Habas, Raymond

“…The Formin proteins are central players in mediating cytoskeletal reorganization and are epistatically positioned in a pathway downstream of Rho activation…”
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Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase by Chen, Hsiang-Chin, Xie, Jia, Zhang, Zheng, Su, Li-Ting, Yue, Lixia, Runnels, Loren W

“…TRPM7 is a ubiquitous divalent-selective ion channel with its own kinase domain. Recent studies have shown that suppression of TRPM7 protein expression by RNA…”
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The TRPM7 channel is inactivated by PIP2 hydrolysis by Runnels, Loren W, Yue, Lixia, Clapham, David E

“…TRPM7 (ChaK1, TRP-PLIK, LTRPC7) is a ubiquitous, calcium-permeant ion channel that is unique in being both an ion channel and a serine/threonine kinase. The…”
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Identification of a novel binding partner of phospholipase cβ1: translin-associated factor X by Aisiku, Omozuanvbo R, Runnels, Loren W, Scarlata, Suzanne

“…Mammalian phospholipase Cβ1 (PLCβ1) is activated by the ubiquitous Gα(q) family of G proteins on the surface of the inner leaflet of plasma membrane where it…”
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Ca2+ Signaling in Cardiac Fibroblasts and Fibrosis-Associated Heart Diseases by Feng, Jianlin, Armillei, Maria K., Yu, Albert S., Liang, Bruce T., Runnels, Loren W., Yue, Lixia

“…Cardiac fibrosis is the excessive deposition of extracellular matrix proteins by cardiac fibroblasts and myofibroblasts, and is a hallmark feature of most…”
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TRPM7 Activates m-Calpain by Stress-Dependent Stimulation of p38 MAPK and c-Jun N-Terminal Kinase by Su, Li-Ting, Chen, Hsiang-Chin, González-Pagán, Omayra, Overton, Jeffrey D., Xie, Jia, Yue, Lixia, Runnels, Loren W.

“…TRPM7 is a Ca2+-permeant and Mg2+-permeant ion channel in possession of its own kinase domain. In a previous study, we showed that overexpression of the…”
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TRPM7 Regulates Cell Adhesion by Controlling the Calcium-dependent Protease Calpain by Su, Li-Ting, Agapito, Maria A., Li, Mingjiang, Simonson, William T.N., Huttenlocher, Anna, Habas, Raymond, Yue, Lixia, Runnels, Loren W.

“…m-Calpain is a protease implicated in the control of cell adhesion through focal adhesion disassembly. The mechanism by which the enzyme is spatially and…”
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Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern by Decker, Amanda R., McNeill, Matthew S., Lambert, Aaron M., Overton, Jeffrey D., Chen, Yu-Chia, Lorca, Ramón A., Johnson, Nicolas A., Brockerhoff, Susan E., Mohapatra, Durga P., MacArthur, Heather, Panula, Pertti, Masino, Mark A., Runnels, Loren W., Cornell, Robert A.

“…Transient receptor potential, melastatin-like 7 (Trpm7) is a combined ion channel and kinase implicated in the differentiation or function of many cell types…”
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Profilin is an effector for Daam1 in non-canonical Wnt signaling and is required for vertebrate gastrulation by Sato, Akira, Khadka, Deepak K, Liu, Wei, Bharti, Ritu, Runnels, Loren W, Dawid, Igor B, Habas, Raymond

“…Non-canonical Wnt signaling plays important roles during vertebrate embryogenesis and is required for cell motility during gastrulation. However, the molecular…”
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TRPM6 and TRPM7: Novel players in cell intercalation during vertebrate embryonic development by Runnels, Loren W., Komiya, Yuko

“…A common theme in organogenesis is how the final structure of organs emerge from epithelial tube structures, with the formation of the neural tube being one of…”
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Interferon-β signaling contributes to Ras transformation by Tsai, Yu-Chen, Pestka, Sidney, Wang, Lu-Hai, Runnels, Loren W, Wan, Shan, Lyu, Yi Lisa, Liu, Leroy F

“…Increasing evidence has pointed to activated type I interferon signaling in tumors. However, the molecular basis for such activation and its role in…”
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TRPM channels and magnesium in early embryonic development by Komiya, Yuko, Runnels, Loren W

“…Magnesium (Mg(2+)) is the second most abundant cellular cation and is essential for all stages of life, from the early embryo to adult. Mg(2+) deficiency…”
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The kinase activity of the channel-kinase protein TRPM7 regulates stability and localization of the TRPM7 channel in polarized epithelial cells by Cai, Na, Lou, Liping, Al-Saadi, Namariq, Tetteh, Sandra, Runnels, Loren W.

“…The channel-kinase transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein with ion channel and kinase domains. The kinase activity of…”
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Mass Spectrometric Analysis of TRPM6 and TRPM7 Phosphorylation Reveals Regulatory Mechanisms of the Channel-Kinases by Cai, Na, Bai, Zhiyong, Nanda, Vikas, Runnels, Loren W.

“…TRPM7 and TRPM6 were the first identified bifunctional channels to contain their own kinase domains, but how these channel-kinases are regulated is poorly…”
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Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity by Xie, Jia, Sun, Baonan, Du, Jianyang, Yang, Wenzhong, Chen, Hsiang-Chin, Overton, Jeffrey D., Runnels, Loren W., Yue, Lixia

“…TRPM6 is crucial for human Mg 2+ homeostasis as patients carrying TRPM6 mutations develop hypomagnesemia and secondary hypocalcemia (HSH). However, the…”
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