Search Results - "Runge, S"

Obesity and natriuretic peptides, BNP and NT-proBNP: Mechanisms and diagnostic implications for heart failure by Madamanchi, Chaitanya, Alhosaini, Hassan, Sumida, Arihiro, Runge, Marschall S

“…Abstract Many advances have been made in the diagnosis and management of heart failure (HF) in recent years. Cardiac biomarkers are an essential tool for…”
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Mitochondrial Dysfunction in Atherosclerosis by Madamanchi, Nageswara R, Runge, Marschall S

“…Increased production of reactive oxygen species in mitochondria, accumulation of mitochondrial DNA damage, and progressive respiratory chain dysfunction are…”
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Oxidative Stress and Vascular Disease by Madamanchi, Nageswara R, Vendrov, Aleksandr, Runge, Marschall S

“…Growing evidence indicates that chronic and acute overproduction of reactive oxygen species (ROS) under pathophysiologic conditions is integral in the…”
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Differential Activation of Mitogenic Signaling Pathways in Aortic Smooth Muscle Cells Deficient in Superoxide Dismutase Isoforms by Madamanchi, Nageswara R, Moon, Sung-Kwon, Hakim, Zeenat S, Clark, Shantres, Mehrizi, Ali, Patterson, Cam, Runge, Marschall S

“…OBJECTIVE—Reactive oxygen species (ROS) integrate cellular signaling pathways involved in aortic smooth muscle cell (SMC) proliferation and migration…”
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Zika transmission patterns: a meta‐review by Runge‐Ranzinger, S., Morrison, A. C., Manrique‐Saide, P., Horstick, O.

“…Summary Objective To assesses what is known and identify knowledge gaps for Zika virus (ZIKV) transmission patterns. Methods Meta‐review searching the…”
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Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening by Canugovi, Chandrika, Stevenson, Mark D, Vendrov, Aleksandr E, Hayami, Takayuki, Robidoux, Jacques, Xiao, Han, Zhang, You-Yi, Eitzman, Daniel T, Runge, Marschall S, Madamanchi, Nageswara R

“…Aging is characterized by increased aortic stiffness, an early, independent predictor and cause of cardiovascular disease. Oxidative stress from excess…”
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Genetics of coronary artery disease and myocardial infarction by Dai, Xuming, Wiernek, Szymon, Evans, James P, Runge, Marschall S

“…Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its…”
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Dengue disease surveillance: an updated systematic literature review by Runge‐Ranzinger, S., McCall, P. J., Kroeger, A., Horstick, O.

“…Objectives To review the evidence for the application of tools for dengue outbreak prediction/detection and trend monitoring in passive and active disease…”
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Oral bioavailability of cyclosporine: Solid lipid nanoparticles (SLN ®) versus drug nanocrystals by Müller, R.H., Runge, S., Ravelli, V., Mehnert, W., Thünemann, A.F., Souto, E.B.

“…For the development of an optimized oral formulation for cyclosporine A, 2% of this drug has been formulated in solid lipid nanoparticles (SLN™, mean size 157…”
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NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis by Vendrov, Aleksandr E, Sumida, Arihiro, Canugovi, Chandrika, Lozhkin, Andrey, Hayami, Takayuki, Madamanchi, Nageswara R, Runge, Marschall S

“…Increased reactive oxygen species (ROS) production and inflammation are key factors in the pathogenesis of atherosclerosis. We previously reported that NOX…”
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Cyclosporine-loaded solid lipid nanoparticles (SLN ®): Drug–lipid physicochemical interactions and characterization of drug incorporation by Müller, R.H., Runge, S.A., Ravelli, V., Thünemann, A.F., Mehnert, W., Souto, E.B.

“…Solid lipid nanoparticles (SLN) were produced loaded with cyclosporine A in order to develop an improved oral formulation. In this study, the particles were…”
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Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice by Verhaegen, Monique E, Harms, Paul W, Van Goor, Julia J, Arche, Jacob, Patrick, Matthew T, Wilbert, Dawn, Zabawa, Haley, Grachtchouk, Marina, Liu, Chia-Jen, Hu, Kevin, Kelly, Michael C, Chen, Ping, Saunders, Thomas L, Weidinger, Stephan, Syu, Li-Jyun, Runge, John S, Gudjonsson, Johann E, Wong, Sunny Y, Brownell, Isaac, Cieslik, Marcin, Udager, Aaron M, Chinnaiyan, Arul M, Tsoi, Lam C, Dlugosz, Andrzej A

“…Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and…”
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Mitochondrial dysfunction and metabolic reprogramming induce macrophage pro-inflammatory phenotype switch and atherosclerosis progression in aging by Vendrov, Aleksandr E, Lozhkin, Andrey, Hayami, Takayuki, Levin, Julia, Silveira Fernandes Chamon, Jamille, Abdel-Latif, Ahmed, Runge, Marschall S, Madamanchi, Nageswara R

“…Aging increases the risk of atherosclerotic vascular disease and its complications. Macrophages are pivotal in the pathogenesis of vascular aging, driving…”
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Predictors of large cell transformation in patients with Sezary Syndrome-A retrospective analysis by Jairath, Neil K, Bardhi, Redina, Runge, John S, Bledea, Ramona, Jairath, Ruple, Wang, Yang, Patrick, Matthew, Wilcox, Ryan A, Hristov, Alexandra C, Tsoi, Lam C, Tejasvi, Trilokraj

“…Large cell transformation (LCT) of Sezary Syndrome (SS) is a rare phenomenon. To date, there are no rigorous studies identifying risk factors for its…”
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Transient abrasion on a rubber sample due to highly dynamic contact conditions by Runge, S., Ignatyev, P.A., Wangenheim, M., Bederna, C., Wies, B., Wallaschek, J.

“…Abrasive processes, primarily the local slip, are the dominant contributor to friction and wear of vehicle tires in service. The time history of forces…”
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Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy by Vendrov, Aleksandr E., Xiao, Han, Lozhkin, Andrey, Hayami, Takayuki, Hu, Guomin, Brody, Matthew J., Sadoshima, Junichi, Zhang, You-Yi, Runge, Marschall S., Madamanchi, Nageswara R.

“…In acute sympathetic stress, catecholamine overload can lead to stress cardiomyopathy. We tested the hypothesis that cardiomyocyte NOX4 (NADPH oxidase…”
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Mitochondrial oxidative stress contributes to diastolic dysfunction through impaired mitochondrial dynamics by Lozhkin, Andrey, Vendrov, Aleksandr E., Ramos-Mondragón, R., Canugovi, Chandrika, Stevenson, Mark D., Herron, Todd J., Hummel, Scott L., Figueroa, C Alberto, Bowles, Dawn E., Isom, Lori L., Runge, Marschall S., Madamanchi, Nageswara R.

“…Diastolic dysfunction (DD) underlies heart failure with preserved ejection fraction (HFpEF), a clinical syndrome associated with aging that is becoming more…”
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Cervical cancer in Tanzania: A systematic review of current challenges in six domains by Runge, Ava S., Bernstein, Megan E., Lucas, Alexa N., Tewari, Krishnansu S.

“…Cervical cancer is the most common cancer in Tanzania. After excluding human immunodeficiency virus, lower respiratory infections, malaria, diarrheal diseases,…”
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In silico and in vitro immunogenicity assessment of B‐domain‐modified recombinant factor VIII molecules by Bartholdy, C., Reedtz‐Runge, S. L., Wang, J., Hjerrild Zeuthen, L., Gruhler, A., Gudme, C. N., Lamberth, K.

“…Introduction B‐domain modification can improve production of recombinant factor VIII (rFVIII) proteins. However, the engineered junction results in non‐native…”
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Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice by Vendrov, Aleksandr E., Stevenson, Mark D., Alahari, Samthosh, Pan, Hua, Wickline, Samuel A., Madamanchi, Nageswara R., Runge, Marschall S.

“…Background Atherosclerosis progression during aging culminates in the development of vulnerable plaques, which may increase the risk of cardiovascular events…”
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