Search Results - "Runbeck, Erin"
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Utilizing Immunocytokines for Cancer Therapy
Published in Antibodies (Basel) (09-03-2021)“…Cytokine therapy for cancer has indicated efficacy in certain diseases but is generally accompanied by severe toxicity. The field of antibody-cytokine fusion…”
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Journal Article -
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Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (18-11-2021)“…The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented…”
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Journal Article -
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Optimising Car T Cell Immunotherapy with a Tumour Microenvironment Targeted Immunocytokine
Published 01-01-2020“…Prostate cancer (PCa) is the most common malignancy in men in the UK. However, the 5-year survival rate of stage IV PCa is 30% and the median survival for the…”
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Dissertation -
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Targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (23-11-2023)“…The majority of oncogenic drivers are intracellular proteins, constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented by…”
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Journal Article -
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Retraction Note: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (23-11-2023)“…Following the publication of our manuscript, a new high-resolution structure of the HLA-A·24:02/PHOX2B peptide/10LH scFv complex by X-ray crystallography…”
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Journal Article -
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RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Published in Nature (London) (18-11-2021)“…The majority of oncogenic drivers are intracellular proteins, thus constraining their immunotherapeutic targeting to mutated peptides (neoantigens) presented…”
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Journal Article -
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Abstract 699: NF-kB is a master regulator of resistance to therapy in high-risk neuroblastoma
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…BACKGROUND High-risk neuroblastoma is a pediatric cancer arising from the developing sympathetic nervous system with a 50% relapse rate that is typically…”
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Journal Article