Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia

Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia

To study the molecular epidemiology of HIV-1 in Krasnoyarsk region, Russia, where HIV-1 has spread rapidly since 2000, we obtained pol sequences from individuals living in this region (n = 67) as well as in the geographically closely related Altay region (n = 13). In both regions, subtype A viruses...

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Bibliographic Details
Published in:AIDS research and human retroviruses Vol. 25; no. 9; p. 931
Main Authors: Rumyantseva, Olga A, Olkhovskiy, Igor A, Malysheva, Marina A, Ruzaeva, Ludmila A, Vasiliev, Alexander V, Kazennova, Elena V, Bobkova, Marina R, Lukashov, Vladimir V
Format: Journal Article
Language:English
Published: United States 01-09-2009
Subjects:
Adult
Anti-HIV Agents - pharmacology
Child
Child, Preschool
Cluster Analysis
Drug Resistance, Viral
Female
Genotype
Geography
HIV Infections - epidemiology
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
HIV-1 - isolation & purification
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation, Missense
Phylogeny
Russia - epidemiology
Sequence Analysis, DNA
Sequence Homology
Young Adult
Russia
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Summary:To study the molecular epidemiology of HIV-1 in Krasnoyarsk region, Russia, where HIV-1 has spread rapidly since 2000, we obtained pol sequences from individuals living in this region (n = 67) as well as in the geographically closely related Altay region (n = 13). In both regions, subtype A viruses specific for the former Soviet Union (IDU-A strains) were dominant (92.5%). Virus sequences clustered according to the geographic origin of the infected individuals rather than to their risk group, demonstrating the role of geographically defined epidemiological networks in the propagation of the HIV-1 epidemic in the region. Six viruses belonged to subtype B. Three of them were phylogenetically (and therefore epidemiologically) closely related to each other, demonstrating that even though IDU-A viruses dominate the epidemic, the spread of other virus strains does occur. Most viruses (75%) had an A62V mutation in reverse transcriptase, specific for HIV-1 strains in Russia. Remarkably, 26 of 47 (55%) patients under HAART with detectable virus loads did not have any known drug-resistant mutation, indicating the need to increase compliance to therapy.
ISSN:1931-8405
DOI:10.1089/aid.2009.0075