Search Results - "Rump, Katharina"

Aquaporins in sepsis- an update by Rump, Katharina, Adamzik, Michael

“…Aquaporins (AQPs), a family of membrane proteins that facilitate the transport of water and small solutes, have garnered increasing attention for their role in…”
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Function of aquaporins in sepsis: a systematic review by Rump, Katharina, Adamzik, Michael

“…Sepsis is a common cause of death in intensive care units worldwide. Due to the high complexity of this immunological syndrome development of novel therapeutic…”
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Epigenetic Mechanisms of Postoperative Cognitive Impairment Induced by Anesthesia and Neuroinflammation by Rump, Katharina, Adamzik, Michael

“…Cognitive impairment after surgery is a common problem, affects mainly the elderly, and can be divided into postoperative delirium and postoperative cognitive…”
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Mitochondrial dysfunction in sepsis is associated with diminished intramitochondrial TFAM despite its increased cellular expression by Rahmel, Tim, Marko, Britta, Nowak, Hartmuth, Bergmann, Lars, Thon, Patrick, Rump, Katharina, Kreimendahl, Sebastian, Rassow, Joachim, Peters, Jürgen, Singer, Mervyn, Adamzik, Michael, Koos, Björn

“…Sepsis is characterized by a dysregulated immune response, metabolic derangements and bioenergetic failure. These alterations are closely associated with a…”
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Midazolam impacts acetyl—And butyrylcholinesterase genes: An epigenetic explanation for postoperative delirium? by Rump, Katharina, Holtkamp, Caroline, Bergmann, Lars, Nowak, Hartmuth, Unterberg, Matthias, Orlowski, Jennifer, Thon, Patrick, Bazzi, Zainab, Bazzi, Maha, Adamzik, Michael, Koos, Björn, Rahmel, Tim

“…Midazolam is a widely used short-acting benzodiazepine. However, midazolam is also criticized for its deliriogenic potential. Since delirium is associated with…”
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The aquaporin 5 -1364A/C promoter polymorphism impacts on resolution of acute kidney injury in pneumonia evoked ARDS by Rahmel, Tim, Nowak, Hartmuth, Rump, Katharina, Siffert, Winfried, Peters, Jürgen, Adamzik, Michael

“…Aquaporin 5 (AQP5) expression impacts on cellular water transport, renal function but also on key mechanisms of inflammation and immune cell migration that…”
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Methazolamide Reduces the AQP5 mRNA Expression and Immune Cell Migration-A New Potential Drug in Sepsis Therapy? by Rump, Katharina, Koos, Björn, Ziehe, Dominik, Thon, Patrick, Rahmel, Tim, Palmowski, Lars, Marko, Britta, Wolf, Alexander, Witowski, Andrea, Bazzi, Zainab, Bazzi, Maha, Orlowski, Jennifer, Adamzik, Michael, Bergmann, Lars, Unterberg, Matthias

“…Sepsis is a life-threatening condition caused by the dysregulated host response to infection. Novel therapeutic options are urgently needed and aquaporin…”
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AQP5-1364A/C Polymorphism Affects AQP5 Promoter Methylation by Rump, Katharina, Spellenberg, Theresa, von Busch, Alexander, Wolf, Alexander, Ziehe, Dominik, Thon, Patrick, Rahmel, Tim, Adamzik, Michael, Koos, Björn, Unterberg, Matthias

“…The quantity of aquaporin 5 protein in neutrophil granulocytes is associated with human sepsis-survival. The C-allele of the aquaporin (AQP5)-1364A/C…”
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Assessing SOFA score trajectories in sepsis using machine learning: A pragmatic approach to improve the accuracy of mortality prediction by Palmowski, Lars, Nowak, Hartmuth, Witowski, Andrea, Koos, Björn, Wolf, Alexander, Weber, Maike, Kleefisch, Daniel, Unterberg, Matthias, Haberl, Helge, von Busch, Alexander, Ertmer, Christian, Zarbock, Alexander, Bode, Christian, Putensen, Christian, Limper, Ulrich, Wappler, Frank, Köhler, Thomas, Henzler, Dietrich, Oswald, Daniel, Ellger, Björn, Ehrentraut, Stefan F, Bergmann, Lars, Rump, Katharina, Ziehe, Dominik, Babel, Nina, Sitek, Barbara, Marcus, Katrin, Frey, Ulrich H, Thoral, Patrick J, Adamzik, Michael, Eisenacher, Martin, Rahmel, Tim

“…An increasing amount of longitudinal health data is available on critically ill septic patients in the age of digital medicine, including daily sequential…”
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The Association between the rs3747406 Polymorphism in the Glucocorticoid-Induced Leucine Zipper Gene and Sepsis Survivals Depends on the SOFA Score by Rusev, Stefan, Thon, Patrick, Rahmel, Tim, Ziehe, Dominik, Marko, Britta, Nowak, Hartmuth, Ellger, Björn, Limper, Ulrich, Schwier, Elke, Henzler, Dietrich, Ehrentraut, Stefan Felix, Bergmann, Lars, Unterberg, Matthias, Adamzik, Michael, Koos, Björn, Rump, Katharina, SepsisDataNet Nrw Research Group

“…The variability in mortality in sepsis could be a consequence of genetic variability. The glucocorticoid system and the intermediate TSC22D3 gene…”
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AQP3 and AQP9-Contrary Players in Sepsis? by Thon, Patrick, Rahmel, Tim, Ziehe, Dominik, Palmowski, Lars, Marko, Britta, Nowak, Hartmuth, Wolf, Alexander, Witowski, Andrea, Orlowski, Jennifer, Ellger, Björn, Wappler, Frank, Schwier, Elke, Henzler, Dietrich, Köhler, Thomas, Zarbock, Alexander, Ehrentraut, Stefan Felix, Putensen, Christian, Frey, Ulrich Hermann, Anft, Moritz, Babel, Nina, Sitek, Barbara, Adamzik, Michael, Bergmann, Lars, Unterberg, Matthias, Koos, Björn, Rump, Katharina

“…Sepsis involves an immunological systemic response to a microbial pathogenic insult, leading to a cascade of interconnected biochemical, cellular, and…”
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The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion by Ziehe, Dominik, Marko, Britta, Thon, Patrick, Rahmel, Tim, Palmowski, Lars, Nowak, Hartmuth, von Busch, Alexander, Wolf, Alexander, Witowski, Andrea, Vonheder, Jolene, Ellger, Björn, Wappler, Frank, Schwier, Elke, Henzler, Dietrich, Köhler, Thomas, Zarbock, Alexander, Ehrentraut, Stefan Felix, Putensen, Christian, Frey, Ulrich Hermann, Anft, Moritz, Babel, Nina, Adamzik, Michael, Koos, Björn, Bergmann, Lars, Unterberg, Matthias, Rump, Katharina

“…Sepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression…”
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The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis by Marko, Britta, Heurich, Paulina, Thon, Patrick, Zimmer, Frieda, Bergmann, Lars, Nowak, Hartmuth, Rump, Katharina, Koos, Björn, Adamzik, Michael, Unterberg, Matthias, Rahmel, Tim

“…The functionally important NF-κB1 promoter polymorphism (−94ins/delATTG) significantly shapes inflammation and impacts the outcome of sepsis. However,…”
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A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes by Holtkamp, Caroline, Koos, Björn, Unterberg, Matthias, Rahmel, Tim, Bergmann, Lars, Bazzi, Zainab, Bazzi, Maha, Bukhari, Hassan, Adamzik, Michael, Rump, Katharina

“…Propofol is a widely used anaesthetic drug with advantageous operating conditions and recovery profile. However, propofol could have long term effects on…”
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Activation of the MAPK network provides a survival advantage during the course of COVID-19-induced sepsis: a real-world evidence analysis of a multicenter COVID-19 Sepsis Cohort by Witowski, Andrea, Palmowski, Lars, Rahmel, Tim, Nowak, Hartmuth, Ehrentraut, Stefan F, Putensen, Christian, von Groote, Thilo, Zarbock, Alexander, Babel, Nina, Anft, Moritz, Sitek, Barbara, Bracht, Thilo, Bayer, Malte, Weber, Maike, Weisheit, Christina, Pfänder, Stephanie, Eisenacher, Martin, Adamzik, Michael, Katharina, Rump, Koos, Björn, Ziehe, Dominik

“…There is evidence that lower activity of the RAF/MEK/ERK network is associated with positive outcomes in mild and moderate courses of COVID-19. The effect of…”
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Exploring the relationship between HCMV serostatus and outcomes in COVID-19 sepsis by Ziehe, Dominik, Wolf, Alexander, Rahmel, Tim, Nowak, Hartmuth, Haberl, Helge, Bergmann, Lars, Rump, Katharina, Dyck, Birte, Palmowski, Lars, Marko, Britta, Witowski, Andrea, Willemsen, Katrin Maria, Pfaender, Stephanie, Eisenacher, Martin, Anft, Moritz, Babel, Nina, Bracht, Thilo, Sitek, Barbara, Bayer, Malte, Zarbock, Alexander, von Groote, Thilo, Putensen, Christian, Ehrentraut, Stefan Felix, Weisheit, Christina, Adamzik, Michael, Unterberg, Matthias, Koos, Björn

“…Sepsis, a life-threatening condition caused by the dysregulated host response to infection, is a major global health concern. Understanding the impact of viral…”
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Corrigendum: The Aquaporin 5 −1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients by Rahmel, Tim, Nowak, Hartmuth, Frisenda, Sandra, Rump, Katharina, Koos, Björn, Schenker, Peter, Viebahn, Richard, Adamzik, Michael, Bergmann, Lars

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The Aquaporin 5 -1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients by Rahmel, Tim, Nowak, Hartmuth, Rump, Katharina, Koos, Björn, Schenker, Peter, Viebahn, Richard, Adamzik, Michael, Bergmann, Lars

“…The aquaporin 5 ( -1364A/C promoter single nucleotide polymorphism affects key mechanisms of inflammation and immune cell migration. Thus, it could be involved…”
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NFKB1 Promoter DNA from nt+402 to nt+99 Is Hypomethylated in Different Human Immune Cells by Unterberg, Matthias, Kreuzer, Maxmiliane Julia, Schäfer, Simon Thomas, Bazzi, Zainab, Adamzik, Michael, Rump, Katharina

“…Sepsis, with a persistently high 90-day mortality of about 46%, is the third most frequent cause of death in intensive care units worldwide. Further…”
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Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock by Schäfer, Simon T, Gessner, Sophia, Scherag, André, Rump, Katharina, Frey, Ulrich H, Siffert, Winfried, Westendorf, Astrid M, Steinmann, Jörg, Peters, Jürgen, Adamzik, Michael

“…Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be…”
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