Search Results - "Rumney, Robin M H"

Biomimetic generation of the strongest known biomaterial found in limpet tooth by Rumney, Robin M. H., Robson, Samuel C., Kao, Alexander P., Barbu, Eugen, Bozycki, Lukasz, Smith, James R., Cragg, Simon M., Couceiro, Fay, Parwani, Rachna, Tozzi, Gianluca, Stuer, Michael, Barber, Asa H., Ford, Alex T., Górecki, Dariusz C.

“…The biomaterial with the highest known tensile strength is a unique composite of chitin and goethite (α-FeO(OH)) present in teeth from the Common Limpet (…”
Get full text

PyMT-Maclow: A novel, inducible, murine model for determining the role of CD68 positive cells in breast tumor development by Rumney, Robin M H, Coffelt, Seth B, Neale, Terence A, Dhayade, Sandeep, Tozer, Gillian M, Miller, Gaynor

“…CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer,…”
Get full text

P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles by Rumney, Robin M H, Róg, Justyna, Chira, Natalia, Kao, Alexander P, Al-Khalidi, Rasha, Górecki, Dariusz C

“…Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs…”
Get full text

The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading by Wang, Ning, Rumney, Robin MH, Yang, Lang, Robaye, Bernard, Boeynaems, Jean‐Marie, Skerry, Timothy M, Gartland, Alison

“…ABSTRACT ATP release and subsequent activation of purinergic receptors has been suggested to be one of the key transduction pathways activated by mechanical…”
Get full text

The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase by Cox, Thomas R, Rumney, Robin M H, Schoof, Erwin M, Perryman, Lara, Høye, Anette M, Agrawal, Ankita, Bird, Demelza, Latif, Norain Ab, Forrest, Hamish, Evans, Holly R, Huggins, Iain D, Lang, Georgina, Linding, Rune, Gartland, Alison, Erler, Janine T

“…Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly…”
Get full text

Investigating the Involvement of C−X−C Motif Chemokine 5 and P2X7 Purinoceptor in Ectopic Calcification in Mouse Models of Duchenne Muscular Dystrophy by Rumney, Robin M. H., Pomeroy, Joanna, Górecki, Dariusz C.

“…ABSTRACT Ectopic calcification of myofibers is an early pathogenic feature in patients and animal models of Duchenne muscular dystrophy (DMD). In previous…”
Get full text

Ablation of the dystrophin Dp71f alternative C-terminal variant increases sarcoma tumour cell aggressiveness by Alnassar, Nancy, Hajto, Jacek, Rumney, Robin M H, Verma, Suraj, Borczyk, Malgorzata, Saha, Chandrika, Kanczler, Janos, Butt, Arthur M, Occhipinti, Annalisa, Pomeroy, Joanna, Angione, Claudio, Korostynski, Michal, Górecki, Dariusz C

“…Alterations in Dp71 expression, the most ubiquitous dystrophin isoform, have been associated with patient survival across tumours. Intriguingly, in certain…”
Get full text

The P2X7 purinoceptor in pathogenesis and treatment of dystrophino- and sarcoglycanopathies by Gόrecki, Dariusz C., Rumney, Robin M.H.

“…Dystrophinopathy and sarcoglycanopathies are incurable diseases caused by mutations in the genes encoding dystrophin or members of the dystrophin associated…”
Get full text

Use of oxygen-loaded nanobubbles to improve tissue oxygenation: Bone-relevant mechanisms of action and effects on osteoclast differentiation by Knowles, Helen J, Vasilyeva, Alexandra, Sheth, Mihir, Pattinson, Oliver, May, Jonathan, Rumney, Robin M H, Hulley, Philippa A, Richards, Duncan B, Carugo, Dario, Evans, Nicholas D, Stride, Eleanor

“…Gas-loaded nanobubbles have potential as a method of oxygen delivery to increase tumour oxygenation and therapeutically alleviate tumour hypoxia. However, the…”
Get full text

Genetically-programmed, mesenchymal stromal cell-laden & mechanically strong 3D bioprinted scaffolds for bone repair by Abu Awwad, Hosam Al-Deen M., Thiagarajan, Lalitha, Kanczler, Janos M., Amer, Mahetab H., Bruce, Gordon, Lanham, Stuart, Rumney, Robin M.H., Oreffo, Richard O.C., Dixon, James E.

“…Additive manufacturing processes used to create regenerative bone tissue engineered implants are not biocompatible, thereby restricting direct use with stem…”
Get full text

Generation of a novel mouse model for the inducible depletion of macrophages in vivo by Gheryani, Nabeia, Coffelt, Seth B., Gartland, Alison, Rumney, Robin M.H., Kiss-Toth, Endre, Lewis, Claire E., Tozer, Gillian M., Greaves, David R., Dear, T. Neil, Miller, Gaynor

“…Macrophages play an essential role in tissue homeostasis, innate immunity, inflammation, and wound repair. Macrophages are also essential during development,…”
Get full text

In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis by Rumney, Robin M. H., Lanham, Stuart A., Kanczler, Janos M., Kao, Alexander P., Thiagarajan, Lalitha, Dixon, James E., Tozzi, Gianluca, Oreffo, Richard O. C.

“…Deficient bone vasculature is a key component in pathological conditions ranging from developmental skeletal abnormalities to impaired bone repair…”
Get full text

Retraction Note: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase by Cox, Thomas R., Rumney, Robin M. H., Schoof, Erwin M., Perryman, Lara, Høye, Anette M., Agrawal, Ankita, Bird, Demelza, Latif, Norain Ab, Forrest, Hamish, Evans, Holly R., Huggins, Iain D., Lang, Georgina, Linding, Rune, Gartland, Alison, Erler, Janine T.

Get full text

Knockout and Knock-in Mouse Models to Study Purinergic Signaling by Rumney, Robin M H, Górecki, Dariusz C

“…Purinergic signaling involves extracellular purines and pyrimidines acting upon specific cell surface purinoceptors classified into the P1, P2X, and P2Y…”
Get more information

Established Models and New Paradigms for Hypoxia-Driven Cancer-Associated Bone Disease by Cox, Thomas R., Erler, Janine T., Rumney, Robin M. H.

“…The five-year survival rate for primary bone cancers is ~ 70% while almost all cases of secondary metastatic bone cancer are terminal. Hypoxia, the deficiency…”
Get full text

Purinergic signalling in osteoblasts by Gartland, Alison, Orriss, Isabel R, Rumney, Robin M H, Bond, Alistair P, Arnett, Timothy, Gallagher, James A

“…The skeleton is maintained throughout life via the finely tuned actions of osteoblasts and osteoclasts, with disruption in this balance eventually leading to…”
Get full text

Purinergic signalling in bone by Rumney, Robin M H, Wang, Ning, Agrawal, Ankita, Gartland, Alison

“…Purinergic signaling in bone was first proposed in the early 1990s with the observation that extracellular ATP could modulate events crucial to the normal…”
Get full text

RETRACTED ARTICLE: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase by Cox, Thomas R., Rumney, Robin M. H., Schoof, Erwin M., Perryman, Lara, Høye, Anette M., Agrawal, Ankita, Bird, Demelza, Latif, Norain Ab, Forrest, Hamish, Evans, Holly R., Huggins, Iain D., Lang, Georgina, Linding, Rune, Gartland, Alison, Erler, Janine T.

“…Metastasis to the bone of certain breast cancers can be driven by the enzyme lysyl oxidase (LOX) produced by primary tumour cells. LOX a key to site of…”
Get full text

Isolation and culture of human osteoblasts by Gartland, Alison, Rumney, Robin M H, Dillon, Jane P, Gallagher, James A

“…The skeleton is a dynamic organ that is constantly active throughout life. The highly coordinated actions of bone cells early in life determine the body's…”
Get more information