Search Results - "Rummler, Maximilian"

In Vivo and In Vitro Mechanical Loading of Mouse Achilles Tendons and Tenocytes-A Pilot Study by Fleischhacker, Viviane, Klatte-Schulz, Franka, Minkwitz, Susann, Schmock, Aysha, Rummler, Maximilian, Seliger, Anne, Willie, Bettina M, Wildemann, Britt

“…Mechanical force is a key factor for the maintenance, adaptation, and function of tendons. Investigating the impact of mechanical loading in tenocytes and…”
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Mechanical loading prevents bone destruction and exerts anti-tumor effects in the MOPC315.BM.Luc model of myeloma bone disease by Rummler, Maximilian, Ziouti, Fani, Bouchard, Alice L., Brandl, Andreas, Duda, Georg N., Bogen, Bjarne, Beilhack, Andreas, Lynch, Maureen E., Jundt, Franziska, Willie, Bettina M.

“…Bone continually adapts to changing external loading conditions via (re)modeling (modeling and remodeling) processes. While physical activity is known to…”
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Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton's Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease by Ziouti, Fani, Rummler, Maximilian, Steyn, Beatrice, Thiele, Tobias, Seliger, Anne, Duda, Georg N, Bogen, Bjarne, Willie, Bettina M, Jundt, Franziska

“…Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent…”
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NOTCH Signaling Is Activated through Mechanical Strain in Human Bone Marrow-Derived Mesenchymal Stromal Cells by Jundt, Franziska, Willie, Bettina M., Luedemann, Martin, Müller-Deubert, Sigrid, Krug, Melanie, Rummler, Maximilian, Ebert, Regina, Ziouti, Fani, Jakob, Franz

“…Skeletal development and remodeling of adult bone are critically controlled by activated NOTCH signaling in genetically modified mice. It is yet unclear…”
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Postembedding Iodine Staining for Contrast‐Enhanced 3D Imaging of Bone Tissue Using Focused Ion Beam‐Scanning Electron Microscopy by Ayoubi, Mahdi, Weinkamer, Richard, van Tol, Alexander F., Rummler, Maximilian, Roschger, Paul, Brugger, Peter C., Berzlanovich, Andrea, Bertinetti, Luca, Roschger, Andreas, Fratzl, Peter

“…For a better understanding of living tissues and materials, it is essential to study the intricate spatial relationship between cells and their surrounding…”
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CHD7 regulates craniofacial cartilage development via controlling HTR2B expression by Breuer, Maximilian, Rummler, Maximilian, Singh, Jaskaran, Maher, Sabrina, Zaouter, Charlotte, Jamadagni, Priyanka, Pilon, Nicolas, Willie, Bettina M, Patten, Shunmoogum A

“…Mutations in the Chromodomain helicase DNA-binding protein 7 - coding gene (CHD7) cause CHARGE syndrome (CS). Although craniofacial and skeletal abnormalities…”
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The Lacunocanalicular Network is Denser in C57BL/6 Compared to BALB/c Mice by Rummler, Maximilian, van Tol, Alexander, Schemenz, Victoria, Hartmann, Markus A., Blouin, Stéphane, Willie, Bettina M., Weinkamer, Richard

“…The lacunocanalicular network (LCN) is an intricate arrangement of cavities (lacunae) and channels (canaliculi), which permeates the mineralized bone matrix…”
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3D Image Registration Marginally Improves the Precision of HR‐pQCT Measurements Compared to Cross‐Sectional‐Area Registration in Adults With Osteogenesis Imperfecta by Hosseinitabatabaei, Seyedmahdi, Mikolajewicz, Nicholas, Zimmermann, Elizabeth A, Rummler, Maximilian, Steyn, Beatrice, Julien, Catherine, Rauch, Frank, Willie, Bettina M

“…ABSTRACT Repositioning error in longitudinal high‐resolution peripheral‐quantitative computed tomography (HR‐pQCT) imaging can lead to different bone volumes…”
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Bone matrix properties in adults with osteogenesis imperfecta are not adversely affected by setrusumab-a sclerostin neutralizing antibody by Rummler, Maximilian, Schemenz, Victoria, McCluskey, Samantha, Davydok, Anton, Rauch, Frank, Glorieux, Francis H, Harrington, Matthew J, Wagermaier, Wolfgang, Willie, Bettina M, Zimmermann, Elizabeth A

“…Osteogenesis imperfecta (OI) is a skeletal dysplasia characterized by low bone mass and frequent fractures. Children with OI are commonly treated with…”
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Bone adaptation to mechanical loading in mice is affected by circadian rhythms by Bouchard, Alice L., Dsouza, Chrisanne, Julien, Catherine, Rummler, Maximilian, Gaumond, Marie-Hélène, Cermakian, Nicolas, Willie, Bettina M.

“…Physical forces are critical for successful function of many organs including bone. Interestingly, the timing of exercise during the day alters physiology and…”
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Multisite longitudinal calibration of HR-pQCT scanners and precision in osteogenesis imperfecta by Mikolajewicz, Nicholas, Zimmermann, Elizabeth A., Rummler, Maximilian, Hosseinitabatabaei, Seyedmahdi, Julien, Catherine, Glorieux, Francis H., Rauch, Frank, Willie, Bettina M.

“…For high-resolution peripheral quantitative computed tomography (HR-pQCT) to be used in longitudinal multi-center studies to assess disease and treatment…”
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Structural and functional heterogeneity of mineralized fibrocartilage at the Achilles tendon-bone insertion by Tits, Alexandra, Blouin, Stéphane, Rummler, Maximilian, Kaux, Jean-François, Drion, Pierre, van Lenthe, G. Harry, Weinkamer, Richard, Hartmann, Markus A., Ruffoni, Davide

“…A demanding task of the musculoskeletal system is the attachment of tendon to bone at entheses. This region often presents a thin layer of fibrocartilage (FC),…”
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Mechanical Loading Shows Anti-Myeloma Effects While Rescuing Bone Loss with Net Bone Formation in a Myeloma Bone Disease Murine Model by Ziouti, Fani, Rummler, Maximilian, Brandl, Andreas, Beilhack, Andreas, Lynch, Maureen, Willie, Bettina, Jundt, Franziska

“…Osteolytic bone disease (BD) is a hallmark of multiple myeloma (MM) with tumor cells in the bone marrow shifting the balance of the bone remodeling process…”
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Resonance Frequency Analysis Identifies Implant- and Host-Related Factors Associated With Bone-Anchored Hearing Implant Stability by Bezdjian, Aren, Mikolajewicz, Nicholas, Denton, Carolyn, Bouchard, Alice, Rummler, Maximilian, Gludovatz, Bernd, Shin, Mihee, Zimmermann, Elizabeth, Salameh, Samer, Daniel, Sam J, Willie, Bettina M

“…Resonance frequency analysis (RFA) is a reliable, noninvasive method to assess the stability of bone-anchored hearing implants (BAHIs), although surgical-,…”
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Rare Diseases in Bone - From Evaluating Models To Testing Treatments by Rummler, Maximilian

“…Bone is a complex organ fulfilling multiple roles within the human body. Due to its multifunctionality, bone can be affected by a multitude of disorders. To…”
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The Effect of Mechanical Loading on Bone Disease in a Model of Multiple Myeloma by Rummler, Maximilian

“…Multiple myeloma is a cancer of white blood cells which migrate to the bone marrow. In the bone marrow cavity these malignant cells interact with the present…”
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In vivo microCT-based time-lapse morphometry reveals anatomical site-specific differences in bone (re)modeling serving as baseline parameters to detect early pathological events by Young, Sarah A.E., Rummler, Maximilian, Taïeb, Hubert M., Garske, Daniela S., Ellinghaus, Agnes, Duda, Georg N., Willie, Bettina M., Cipitria, Amaia

“…The bone structure is very dynamic and continuously adapts its geometry to external stimuli by modeling and remodeling the mineralized tissue. In vivo…”
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Effects of aging on the osteocyte lacuno-canalicular network in human osteonal bone by Jones, Chloe, Blouin, Stéphane, Rummler, Maximilian, Weinkamer, Richard, Berzlanovich, Andrea, Hartmann, Markus A.

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Transcriptional profiling of cortical bone after mechanical loading in the MOPC315.BM myeloma bone disease model by Ziouti, Fani, Rummler, Maximilian, Julien, Catherine, Ebert, Regina, Jakob, Franz, Willie, Bettina, Jundt, Franziska

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Targeted Remodeling of the Tumor Microenvironment Via Mechanical Stimulation Defines a Novel Therapeutic Strategy in Myeloma Bone Disease by Ziouti, Fani, Rummler, Maximilian, Seliger, Anne, Brandl, Andreas, Beilhack, Andreas, Bogen, Bjarne, Lynch, Maureen, Jakob, Franz, Ebert, Regina, Willie, Bettina, Jundt, Franziska

“…Multiple myeloma (MM) patients develop devastating osteolytic bone disease causing non-healing bone fractures and pain. MM cells in the bone marrow…”
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