Search Results - "Rumfelt, Lynn L"

Lineage specification and plasticity in CD19- early B cell precursors by Rumfelt, Lynn L, Zhou, Yan, Rowley, Benjamin M, Shinton, Susan A, Hardy, Richard R

“…We describe here three CD19- B cell precursor populations in mouse bone marrow identified using 12-color flow cytometry. Cell transfer experiments indicate…”
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Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark by Rumfelt, Lynn L, Lohr, Rebecca L, Dooley, Helen, Flajnik, Martin F

“…Adult cartilaginous fish express three immunoglobulin (Ig) isotypes, IgM, IgNAR and IgW. Newborn nurse sharks, Ginglymostoma cirratum, produce 19S (multimeric)…”
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Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages by Porritt, Helen E, Rumfelt, Lynn L, Tabrizifard, Sahba, Schmitt, Thomas M, Zúñiga-Pflücker, Juan Carlos, Petrie, Howard T

“…The nature of early T lineage progenitors in the thymus or bone marrow remains controversial. Here we assess lineage capacity and proliferative potential among…”
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The plasticity of immunoglobulin gene systems in evolution by Hsu, Ellen, Pulham, Nicolas, Rumfelt, Lynn L., Flajnik, Martin F.

“…The mechanism of recombination‐activating gene (RAG)‐mediated rearrangement exists in all jawed vertebrates, but the organization and structure of…”
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Unprecedented Multiplicity of Ig Transmembrane and Secretory mRNA Forms in the Cartilaginous Fish by Rumfelt, Lynn L, Diaz, Marilyn, Lohr, Rebecca L, Mochon, Evonne, Flajnik, Martin F

“…In most jawed vertebrates including cartilaginous fish, membrane-bound IgM is expressed as a five Ig superfamily (Igsf)-domain H chain attached to a…”
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A Shark Antibody Heavy Chain Encoded by a Nonsomatically Rearranged VDJ is Preferentially Expressed in Early Development and is Convergent with Mammalian IgG by Rumfelt, Lynn L., Avila, David, Diaz, Marilyn, Bartl, Simona, McKinney, E. Churchill, Flajnik, Martin F.

“…In most vertebrate embryos and neonates studied to date unique antigen receptors (antibodies and T cell receptors) are expressed that possess a limited immune…”
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J Chain in the Nurse Shark: Implications for Function in a Lower Vertebrate by Hohman, Valerie S, Stewart, Sue E, Rumfelt, Lynn L, Greenberg, Andrew S, Avila, David W, Flajnik, Martin F, Steiner, Lisa A

“…J chain is a small polypeptide covalently attached to polymeric IgA and IgM. In humans and mice, it plays a role in binding Ig to the polymeric Ig receptor for…”
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Immunoglobulins in the eggs of the nurse shark, Ginglymostoma cirratum by Haines, Ashley N., Flajnik, Martin F., Rumfelt, Lynn L., Wourms, John P.

“…Elasmobranchs, which include the sharks, skates, and rays, emerged over 450 million years ago and are the oldest vertebrates to possess an adaptive immune…”
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Xenopus class II A genes: studies of genetics, polymorphism, and expression by Liu, Yu, Kasahara, Masanori, Rumfelt, Lynn L, Flajnik, Martin F

“…The amphibian Xenopus laevis has been a central model for the study of evolution of the major histocompatibility complex (MHC). Many of the counterparts of…”
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Terminal deoxynucleotidyl transferases from elasmobranchs reveal structural conservation within vertebrates by Bartl, Simona, Miracle, Ann L, Rumfelt, Lynn L, Kepler, Thomas B, Mochon, Evonne, Litman, Gary W, Flajnik, Martin F

“…The DNA polymerase (pol) X family is an ancient group of enzymes that function in DNA replication and repair (pol beta), translesion synthesis (pol lambda and…”
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The plasticity of immunoglobulin gene systems in evolution: Genomics & proteomics by HSU, Ellen, PULHAM, Nicolas, RUMFELT, Lynn L, FLAJNIK, Martin F

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Lineage specification and plasticity in CD19 super(-) early B cell precursors by Rumfelt, Lynn L, Zhou, Yan, Rowley, Benjamin M, Shinton, Susan A, Hardy, Richard R

“…We describe here three CD19 super(-) B cell precursor populations in mouse bone marrow identified using 12-color flow cytometry. Cell transfer experiments…”
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A shark antibody heavy chain encoded by a nonsomatically rearranged VDJ is preferentially expressed in early develoment and is convergent with mammalian IgG by Rumfelt, Lynn L, Avila, David, Diaz, Marilyn, Bartl, Simona

“…In most vertebrate embryos and neonates studied to date unique antigen receptors (antibodies and T cell receptors) are expressed that possess a limited immune…”
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