Search Results - "Rukhadze, Irma"

Kölliker–Fuse GABAergic and glutamatergic neurons project to distinct targets by Geerling, Joel C., Yokota, Shigefumi, Rukhadze, Irma, Roe, Dan, Chamberlin, Nancy L.

“…The Kölliker‐Fuse nucleus (KF) is known primarily for its respiratory function as the “pneumotaxic center” or “pontine respiratory group.” Considered part of…”
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Neuroanatomical Basis of State-Dependent Activity of Upper Airway Muscles by Rukhadze, Irma, Fenik, Victor B

“…Obstructive Sleep Apnea (OSA) is a common sleep-related respiratory disorder that is associated with cognitive, cardiovascular, and metabolic morbidities. The…”
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Chronic Intermittent Hypoxia Alters Density of Aminergic Terminals and Receptors in the Hypoglossal Motor Nucleus by RUKHADZE, Irma, FENIK, Victor B, BENINCASA, Kate E, PRICE, Andrea, KUBIN, Leszek

“…Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper…”
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Hypoglossal premotor neurons of the intermediate medullary reticular region express cholinergic markers by Volgin, Denys V, Rukhadze, Irma, Kubin, Leszek

“…Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia,…”
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Disinhibition of perifornical hypothalamic neurones activates noradrenergic neurones and blocks pontine carbachol-induced REM sleep-like episodes in rats by Lu, Jackie W., Fenik, Victor B., Branconi, Jennifer L., Mann, Graziella L., Rukhadze, Irma, Kubin, Leszek

“…Studies in behaving animals suggest that neurones located in the perifornical (PF) region of the posterior hypothalamus promote wakefulness and suppress sleep…”
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0228 Chemogenetic Activation of Noradrenergic A7 and SubCoeruleus Neurons Inhibits Generation of REM Sleep in Aging Mice by FrassondosReis, Leonardo, Yadav, Raghunandan Kumar, Fenik, Victor, Rukhadze, Irma

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Activity of Pontine A7 Noradrenergic Neurons is suppressed during REM sleep by Fenik, Victor B, Rukhadze, Irma

“…The activity of hypoglossal motoneurons plays a key role in the maintenance of upper airway patency. The withdrawal of noradrenergic excitatory drive and…”
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0038 Genioglossus muscle (GG) activity evoked by pharmacological stimulation of alpha1-adrenoceptors in pre-hypoglossal region (PHR) by Reis, Leonardo Frasson, Xu, Kelly, Rukhadze, Irma, Fenik, Victor

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0001 The Innervation Of Hypoglossal Motoneurons That Originates From A7 And/or Subcoeruleus Noradrenergic Neurons Is Impaired In Mice Treated With Chronic Intermittent Hypoxia by Rukhadze, Irma, Gvritishvili, Anzor, Kvizhinadze, Maya, Fenik, Victor B

“…Introduction Noradrenergic (NA) neurons of A7 and SubCoeruleus (SubC) pontine nuclei project to the hypoglossal (XII) nucleus and provide excitatory input to…”
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Mesopontine cholinergic projections to the hypoglossal motor nucleus by Rukhadze, Irma, Kubin, Leszek

“…Mesopontine cholinergic (ACh) neurons have increased discharge during wakefulness, rapid eye movement (REM) sleep, or both. Hypoglossal (12) motoneurons, which…”
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Chronic intermittent hypoxia attenuates noradrenergic innervation of hypoglossal motor nucleus by Herlihy, Rachael, Frasson Dos Reis, Leonardo, Gvritishvili, Anzor, Kvizhinadze, Maya, Dybas, Elizabeth, Malhotra, Atul, Fenik, Victor B, Rukhadze, Irma

“…The state-dependent noradrenergic activation of hypoglossal motoneurons plays an important role in the maintenance of upper airway patency and pathophysiology…”
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Differential pontomedullary catecholaminergic projections to hypoglossal motor nucleus and viscerosensory nucleus of the solitary tract by Rukhadze, Irma, Kubin, Leszek

“…In individuals with a narrow or collapsible upper airway, sleep-related hypotonia of upper airway muscles leads to recurrent airway obstructions. Brainstem…”
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Computational model of brain-stem circuit for state-dependent control of hypoglossal motoneurons by Naji, Mohsen, Komarov, Maxim, Krishnan, Giri P, Malhotra, Atul, Powell, Frank L, Rukhadze, Irma, Fenik, Victor B, Bazhenov, Maxim

“…In patients with obstructive sleep apnea (OSA), the pharyngeal muscles become relaxed during sleep, which leads to a partial or complete closure of upper…”
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Rats subjected to chronic-intermittent hypoxia have increased density of noradrenergic terminals in the trigeminal sensory and motor nuclei by Mody, Pari, Rukhadze, Irma, Kubin, Leszek

“…► Chronic intermittent hypoxia (CIH) is a pathogenic factor in sleep apnea syndrome. ► We quantified noradrenergic (NE) terminals in trigeminal motor and…”
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Catecholaminergic A1/C1 neurons contribute to the maintenance of upper airway muscle tone but may not participate in NREM sleep-related depression of these muscles by Rukhadze, Irma, Carballo, Nancy J., Bandaru, Sathyajit S., Malhotra, Atul, Fuller, Patrick M., Fenik, Victor B.

“…•We investigated, for the first time, the functional relation between catecholaminergic A1C1 neurons and GG muscle activity in behaving mice.•Catecholaminergic…”
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Respiratory modulation of lingual muscle activity across sleep–wake states in rats by Stettner, Georg M, Rukhadze, Irma, Mann, Graziella L, Lei, Yanlin, Kubin, Leszek

“…Highlights • Inspiratory activation (IA) of upper airway muscles protects the airway from collapse. • IA of upper airway muscle tone is rare in rats, and its…”
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Antagonism of alpha sub(1)-adrenergic and serotonergic receptors in the hypoglossal motor nucleus does not prevent motoneuronal activation elicited from the posterior hypothalamus by Fenik, Victor B, Rukhadze, Irma, Kubin, Leszek

“…The perifornical (PF) region of the posterior hypothalamus plays an important role in the regulation of sleep-wake states and motor activity. Disinhibition of…”
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Lingual Muscle Activity Across Sleep–Wake States in Rats with Surgically Altered Upper Airway by Rukhadze, Irma, Kalter, Julie, Stettner, Georg M., Kubin, Leszek

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Antagonism of α1-adrenergic and serotonergic receptors in the hypoglossal motor nucleus does not prevent motoneuronal activation elicited from the posterior hypothalamus by FENIK, Victor B, RUKHADZE, Irma, KUBIN, Leszek

“…The perifornical (PF) region of the posterior hypothalamus plays an important role in the regulation of sleep-wake states and motor activity. Disinhibition of…”
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Antagonism of α 1-adrenergic and serotonergic receptors in the hypoglossal motor nucleus does not prevent motoneuronal activation elicited from the posterior hypothalamus by Fenik, Victor B., Rukhadze, Irma, Kubin, Leszek

“…The perifornical (PF) region of the posterior hypothalamus plays an important role in the regulation of sleep–wake states and motor activity. Disinhibition of…”
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