Search Results - "Ruiz i Altaba, A"

Gli proteins encode context-dependent positive and negative functions: implications for development and disease by Ruiz i Altaba, A

“…Several lines of evidence implicate zinc finger proteins of the Gli family in the final steps of Hedgehog signaling in normal development and disease…”
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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours by Altaba, A. Ruiz i, Dahmane, N, Lee, J, Robins, P, Heller, P

“…Sporadic basal cell carcinoma (BCC) is the most common type of malignant cancer in fair-skinned adults. Familial BCCs and a fraction of sporadic BCCs have lost…”
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Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog by Ruiz i Altaba, A

“…Within the developing vertebrate nervous system, it is not known how progenitor cells interpret the positional information provided by inducing signals or how…”
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Gli/Zic factors pattern the neural plate by defining domains of cell differentiation by Altaba, A. Ruiz i, Brewster, R, Lee, J

“…Three cell types differentiate in the early frog neural plate: neural crest at the lateral edges, floorplate at the midline and primary neurons in three…”
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Gli2 functions in FGF signaling during antero-posterior patterning by Brewster, R, Mullor, J L, Ruiz i Altaba, A

“…Patterning along the anteroposterior (A-P) axis involves the interplay of secreted and transcription factors that specify cell fates in the mesoderm and…”
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Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis by I ALTABA, A. R, JESSELL, T. M

“…We have identified a novel frog gene, Pintallavis (the Catalan for lipstick), that is related to the fly fork head and rat HNF-3 genes. Pintallavis is…”
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Pattern formation in the vertebrate neural plate by Ruiz i Altaba, A

“…Recent advances have been made in the understanding of the cellular and molecular mechanisms involved in the formation and patterning of the neural plate of…”
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Planar and vertical signals in the induction and patterning of the Xenopus nervous system by I ALTABA, A. R

“…The cellular mechanisms responsible for the formation of the Xenopus nervous system have been examined in total exogastrula embryos in which the axial mesoderm…”
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Expression of the vertebrate Gli proteins in Drosophila reveals a distribution of activator and repressor activities by Aza-Blanc, P, Lin, H-Y, Altaba, ARI, Kornberg, T B

“…The Cubitus interruptus (Ci) and Gli proteins are transcription factors that mediate responses to Hedgehog proteins (Hh) in flies and vertebrates,…”
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On hedgehogs and human cancer by Ruiz i Altaba, A., Varnat, F.

“…[...]is our conclusion that HH‐GLI signalling is essential in human sporadic CCs based solely on data with cyclopamine? Fourth, in what concerns the CC and…”
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Context-dependent Regulation of the GLI Code in Cancer by HEDGEHOG and Non-HEDGEHOG Signals by Stecca, Barbara, Ruiz i Altaba, Ariel

“…A surprisingly large and unrelated number of human tumors depend on sustained HEDGEHOG-GLI (HH-GLI) signaling for growth. This includes cancers of the skin,…”
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Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord by Roelink, H, Augsburger, A, Heemskerk, J, Korzh, V, Norlin, S, Ruiz i Altaba, A, Tanabe, Y, Placzek, M, Edlund, T, Jessell, T M

“…The differentiation of distinct cell types in the ventral neural tube depends on local inductive signals from the notochord. We have isolated a vertebrate…”
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Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos by i Altaba, A. Ruiz, Melton, D. A

“…The expression of the Xenopus homoeobox gene xhox3 is an early response to mesoderm induction by peptide growth factors and the level of xhox3 expression marks…”
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Neural expression of the Xenopus homeobox gene Xhox3: evidence for a patterning neural signal that spreads through the ectoderm by RUIZ I ALTABA, A

“…The Xenopus laevis homeobox gene Xhox3 is expressed in the axial mesoderm of gastrula and neurula stage embryos. By the late neurula-early tailbud stage,…”
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Ectopic Neural Expression of a Floor Plate Marker in Frog Embryos Injected With the Midline Transcription Factor Pintallavis by A. Ruiz I Altaba, Cox, C., Jessell, T. M., Klar, A.

“…The floor plate, a cell group that develops at the midline of the neural plate in response to inductive signals from the notochord, has been implicated in the…”
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Alberto Gulino MD, PhD (1952-2014) Obituary by Toftgard, R, Ruiz, i Altaba A

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Alberto Gulino MD, PhD (1952–2014) by Toftgård, R, Ruiz i Altaba, A

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Sonic hedgehog regulates the growth and patterning of the cerebellum by Dahmane, N, Ruiz i Altaba, A

“…The molecular bases of brain development and CNS malignancies remain poorly understood. Here we show that Sonic hedgehog (Shh) signaling controls the…”
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Morphogenetic action through flux-limited spreading by Verbeni, M., Sánchez, O., Mollica, E., Siegl-Cachedenier, I., Carleton, A., Guerrero, I., Ruiz i Altaba, A., Soler, J.

“…A central question in biology is how secreted morphogens act to induce different cellular responses within a group of cells in a concentration-dependent…”
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Retinoic acid modifies the pattern of cell differentiation in the central nervous system of neurula stage Xenopus embryos by RUIZ ALTABA, A, JESSELL, T. M

“…Neural cell markers have been used to examine the effect of retinoic acid (RA) on the development of the central nervous system (CNS) of Xenopus embryos. RA…”
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