Search Results - "Ruiz de Galarreta, Marina"

Therapeutic editing of hepatocyte genome in vivo by de Galarreta, Marina Ruiz, Lujambio, Amaia

“…Abstract The recent development of gene editing platforms enables making precise changes in the genome of eukaryotic cells. Programmable nucleases, such as…”
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Mouse Models of Oncoimmunology in Hepatocellular Carcinoma by Bresnahan, Erin, Lindblad, Katherine E, Ruiz de Galarreta, Marina, Lujambio, Amaia

“…Liver cancer is the fourth leading cause of cancer-related mortality worldwide and incidence is on the rise. Hepatocellular carcinoma (HCC) is the most common…”
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Transcriptomic characterization of cancer-testis antigens identifies MAGEA3 as a driver of tumor progression in hepatocellular carcinoma by Craig, Amanda J, Garcia-Lezana, Teresa, Ruiz de Galarreta, Marina, Villacorta-Martin, Carlos, Kozlova, Edgar G, Martins-Filho, Sebastiao N, von Felden, Johann, Ahsen, Mehmet Eren, Bresnahan, Erin, Hernandez-Meza, Gabriela, Labgaa, Ismail, D'Avola, Delia, Schwartz, Myron, Llovet, Josep M, Sia, Daniela, Thung, Swan, Losic, Bojan, Lujambio, Amaia, Villanueva, Augusto

“…Cancer testis antigens (CTAs) are an extensive gene family with a unique expression pattern restricted to germ cells, but aberrantly reactivated in cancer…”
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Cold-Inducible RNA Binding Protein as a Vaccination Platform to Enhance Immunotherapeutic Responses Against Hepatocellular Carcinoma by Silva, Leyre, Egea, Josune, Villanueva, Lorea, Ruiz, Marta, Llopiz, Diana, Repáraz, David, Aparicio, Belén, Lasarte-Cia, Aritz, Lasarte, Juan José, Ruiz de Galarreta, Marina, Lujambio, Amaia, Sangro, Bruno, Sarobe, Pablo

“…Therapies based on immune checkpoint inhibitors (ICPI) have yielded promising albeit limited results in patients with hepatocellular carcinoma (HCC). Vaccines…”
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Genetic Modification of CD8 + T Cells to Express EGFR: Potential Application for Adoptive T Cell Therapies by Lozano, Teresa, Chocarro, Silvia, Martin, Celia, Lasarte-Cia, Aritz, Del Valle, Cynthia, Gorraiz, Marta, Sarrión, Patricia, Ruiz de Galarreta, Marina, Lujambio, Amaia, Hervás-Stubbs, Sandra, Sarobe, Pablo, Casares, Noelia, Lasarte, Juan J

“…Adoptive immunotherapy with -expanded tumor-infiltrating lymphocytes (TILs) has achieved objective clinical responses in a significant number of patients with…”
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Manipulating and tracking single hepatocyte behavior during mouse liver regeneration by performing hydrodynamic tail vein injection by Wang, Shuang, Ruiz de Galarreta, Marina, Sadler, Kirsten C., Lujambio, Amaia

“…Studies to identify genes relevant to mammalian hepatocyte biology in vivo are largely carried out using germline genetic-engineering approaches, which can be…”
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Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC by Piqué-Gili, Marta, Andreu-Oller, Carmen, Mesropian, Agavni, Esteban-Fabró, Roger, Bárcena-Varela, Marina, Ruiz de Galarreta, Marina, Montironi, Carla, Martinez-Quetglas, Iris, Cappuyns, Sarah, Peix, Judit, Keraite, Ieva, Gris-Oliver, Albert, Fernández-Martínez, Elisa, Mauro, Ezequiel, Torres-Martin, Miguel, Abril-Fornaguera, Jordi, Lindblad, Katherine E., Lambrechts, Diether, Dekervel, Jeroen, Thung, Swan N., Sia, Daniela, Lujambio, Amaia, Pinyol, Roser, Llovet, Josep M.

“…Transforming growth factor β (TGF-β) plays an oncogenic role in advanced cancer by promoting cell proliferation, metastasis and immunosuppression. PMEPA1…”
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623 Notch orchestrates a multifaceted immune evasion program in hepatocellular carcinoma by Lindblad, Katherine, Galarreta, Marina Ruiz de, Donne, Romain, Bárcena-Varela, Marina, Liebling, Ian, Repáraz, David, Yao, Melissa, Dhainaut, Maxime, Brown, Brian, Kamphorst, Alice, Lujambio, Amaia

“…BackgroundHepatocellular carcinoma (HCC) is a major global health concern, causing over 700,000 deaths annually [1]. For decades, treatment for advanced HCC…”
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β-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma by Ruiz de Galarreta, Marina, Bresnahan, Erin, Molina-Sánchez, Pedro, Lindblad, Katherine E, Maier, Barbara, Sia, Daniela, Puigvehi, Marc, Miguela, Verónica, Casanova-Acebes, María, Dhainaut, Maxime, Villacorta-Martin, Carlos, Singhi, Aatur D, Moghe, Akshata, von Felden, Johann, Tal Grinspan, Lauren, Wang, Shuang, Kamphorst, Alice O, Monga, Satdarshan P, Brown, Brian D, Villanueva, Augusto, Llovet, Josep M, Merad, Miriam, Lujambio, Amaia

“…PD-1 immune checkpoint inhibitors have produced encouraging results in patients with hepatocellular carcinoma (HCC). However, what determines resistance to…”
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DNA sensing in senescence by Ruiz de Galarreta, Marina, Lujambio, Amaia

“…Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic non-cell-autonomous activities through the senescence-associated…”
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Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma by Bollard, Julien, Miguela, Verónica, Ruiz de Galarreta, Marina, Venkatesh, Anu, Bian, C Billie, Roberto, Mark P, Tovar, Victoria, Sia, Daniela, Molina-Sánchez, Pedro, Nguyen, Christie B, Nakagawa, Shigeki, Llovet, Josep M, Hoshida, Yujin, Lujambio, Amaia

“…Advanced hepatocellular carcinoma (HCC) is a lethal malignancy with limited treatment options. Palbociclib, a well-tolerated and selective CDK4/6 inhibitor,…”
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Cartilage oligomeric matrix protein participates in the pathogenesis of liver fibrosis by Magdaleno, Fernando, Arriazu, Elena, Ruiz de Galarreta, Marina, Chen, Yu, Ge, Xiaodong, Conde de la Rosa, Laura, Nieto, Natalia

“…Graphical abstract…”
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Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma by Molina-Sánchez, Pedro, Ruiz de Galarreta, Marina, Yao, Melissa A., Lindblad, Katherine E., Bresnahan, Erin, Bitterman, Elizabeth, Martin, Tiphaine C., Rubenstein, Troy, Nie, Kai, Golas, Jonathan, Choudhary, Shambhunath, Bárcena-Varela, Marina, Elmas, Abdulkadir, Miguela, Veronica, Ding, Ying, Kan, Zhengyan, Grinspan, Lauren Tal, Huang, Kuan-Lin, Parsons, Ramon E., Shields, David J., Rollins, Robert A., Lujambio, Amaia

“…The pattern of genetic alterations in cancer driver genes in patients with hepatocellular carcinoma (HCC) is highly diverse, which partially explains the low…”
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Extracellular matrix and liver disease by Arriazu, Elena, Ruiz de Galarreta, Marina, Cubero, Francisco Javier, Varela-Rey, Marta, Pérez de Obanos, María Pilar, Leung, Tung Ming, Lopategi, Aritz, Benedicto, Aitor, Abraham-Enachescu, Ioana, Nieto, Natalia

“…The extracellular matrix (ECM) is a dynamic microenvironment that undergoes continuous remodeling, particularly during injury and wound healing. Chronic liver…”
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Tumor-Intrinsic Mechanisms Regulating Immune Exclusion in Liver Cancers by Lindblad, Katherine E, Ruiz de Galarreta, Marina, Lujambio, Amaia

“…Representing the fourth leading cause of cancer-related mortality worldwide, liver cancers constitute a major global health concern. Hepatocellular carcinoma…”
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Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology by Yu, Jia Xin, Craig, Amanda J, Duffy, Mary E, Villacorta-Martin, Carlos, Miguela, Verónica, Ruiz de Galarreta, Marina, Scopton, Alexander P, Silber, Lisa, Maldonado, Andres Y, Rialdi, Alexander, Guccione, Ernesto, Lujambio, Amaia, Villanueva, Augusto, Dar, Arvin C

“…The approved kinase inhibitors for hepatocellular carcinoma (HCC) are not matched to specific mutations within tumors. This has presented a daunting challenge;…”
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Unfolded protein response induced by Brefeldin A increases collagen type I levels in hepatic stellate cells through an IRE1α, p38 MAPK and Smad-dependent pathway by de Galarreta, Marina Ruiz, Navarro, Amaia, Ansorena, Eduardo, Garzón, Antonia García, Mòdol, Teresa, López-Zabalza, María J., Martínez-Irujo, Juan J., Iraburu, María J.

“…Unfolded protein response (UPR) triggered as a consequence of ER stress has been shown to be involved in the development of different pathologies, including…”
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Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells by Ruiz de Galarreta, Marina, Arriazu, Elena, Pérez de Obanos, María P., Ansorena, Eduardo, Iraburu, María J.

“…Ocoxin is a nutritional supplement that has been shown to exert antioxidant and immunomodulatory responses in patients with chronic hepatitis C. The present…”
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Oxidation pathways underlying the pro-oxidant effects of apigenin by Andueza, Aitor, García-Garzón, Antonia, Ruiz de Galarreta, Marina, Ansorena, Eduardo, Iraburu, María J., López-Zabalza, María J., Martínez-Irujo, Juan J.

“…Apigenin, a natural flavone, is emerging as a promising compound for the treatment of several diseases. One of the hallmarks of apigenin is the generation of…”
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Cell type-specific pharmacological kinase inhibition for cancer chemoprevention by Deshmukh, Manjeet, Nakagawa, Shigeki, Higashi, Takaaki, Vincek, Adam, Venkatesh, Anu, Ruiz de Galarreta, Marina, Koh, Anna P, Goossens, Nicolas, Hirschfield, Hadassa, Bian, C Billie, Fujiwara, Naoto, Ono, Atsushi, Hoshida, Hiroki, El-Abtah, Mohamed, Ahmad, Noor B, Lujambio, Amaia, Sanchez, Roberto, Fuchs, Bryan C, Poelstra, Klaas, Prakash, Jai, Hoshida, Yujin

“…Safety is prerequisite for preventive medicine, but non-toxic agents are generally ineffective as clinical chemoprevention. Here we propose a strategy…”
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