TREM-1 modulation during early stages of dengue virus infection

Highlights • Evaluation of surface and soluble TREM-1 levels in DENV-infected patients was made. • A significant reduction of TREM-1 expression was observed in neutrophils. • Sera from DENV-infected patients exhibited significantly higher of soluble TREM-1 levels during the first 5 days after the sy...

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Bibliographic Details
Published in:	Immunology letters Vol. 158; no. 1; pp. 183 - 188
Main Authors:	Ruiz-Pacheco, J.A, Vivanco-Cid, H, Izaguirre-Hernández, I.Y, Estrada-García, I, Arriaga-Pizano, L, Chacón-Salinas, R, Fonseca-Coronado, S, Vaughan, G, Ruiz Tovar, K, Rivera-Osorio, M.P, Escobar-Gutiérrez, A
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-03-2014
Subjects:	Adolescent Adult Allergy and Immunology Cells, Cultured Child Dengue - immunology Dengue virus Dengue Virus - immunology Disease Progression Female Gene Expression Regulation Humans Immunity, Innate Immunomodulation Innate immunity Male Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - blood Membrane Glycoproteins - genetics Middle Aged Monocytes - immunology Monocytes - virology Neutrophils - immunology Neutrophils - virology Receptors, Immunologic - biosynthesis Receptors, Immunologic - blood Receptors, Immunologic - genetics sTREM-1 TREM-1 Triggering Receptor Expressed on Myeloid Cells-1 Young Adult TREM-1 Innate immunity sTREM-1 Dengue virus
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Summary:	Highlights • Evaluation of surface and soluble TREM-1 levels in DENV-infected patients was made. • A significant reduction of TREM-1 expression was observed in neutrophils. • Sera from DENV-infected patients exhibited significantly higher of soluble TREM-1 levels during the first 5 days after the symptoms onset. • The increment of sTREM-1 could be a compensatory mechanism to counteract the inflammatory process elicited by DENV infection. • These data are the first to show the involvement of TREM-1 during DENV infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2014.01.003