Search Results - "Ruiz Picazo, Alejandro"

In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug by Gonzalez-Alvarez, Isabel, Ruiz-Picazo, Alejandro, Selles-Talavera, Ruben, Figueroa-Campos, Andres, Merino, Virginia, Bermejo, Marival, Gonzalez-Alvarez, Marta

“…The purpose of this study was to predict the in vivo bioequivalence (BE) outcome of valsartan (VALS, BCS class IV) from three oral-fixed combination products…”
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In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC by Ruiz Picazo, Alejandro, Martinez-Martinez, M, Colón-Useche, Sarin, Iriarte, Ramon, Sánchez-Dengra, Bárbara, González-Álvarez, Marta, García-Arieta, Alfredo, González-Álvarez, Isabel, Bermejo, Marival

“…The purpose of this investigation was to develop an exploratory two-step level A IVIVC for three telmisartan oral immediate release formulations, the reference…”
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Comparison of segmental-dependent permeability in human and in situ perfusion model in rat by Ruiz-Picazo, Alejandro, Lozoya-Agullo, Isabel, Ortiz-Azcarate, Miguel, Merino-Sanjuán, Matilde, González-Álvarez, Marta, González-Álvarez, Isabel, Bermejo, Marival

“…Nowadays, alternative methods have been developed to predict intestinal permeability values in human as in vitro, in situ or ex vivo methods. They were…”
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Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole by Cabañero-Resta, Gema J, Sánchez-Dengra, Bárbara, Ruiz-Picazo, Alejandro, Bermejo, Marival, Merino, Virginia, Gonzalez-Alvarez, Isabel, Gonzalez-Alvarez, Marta

“…Itraconazole is a drug used in veterinary medicine for the treatment of different varieties of dermatophytosis at doses between 3-5 mg/kg/day in cats…”
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Exploring a Bioequivalence Failure for Silodosin Products Due to Disintegrant Excipients by González-Álvarez, Isabel, Sánchez-Dengra, Bárbara, Rodriguez-Galvez, Raquel, Ruiz-Picazo, Alejandro, González-Álvarez, Marta, García-Arieta, Alfredo, Bermejo, Marival

“…Some years ago, excipients were considered inert substances irrelevant in the absorption process. However, years of study have demonstrated that this belief is…”
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An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products by Gonzalez-Alvarez, Isabel, Bermejo, Marival, Tsume, Yasuhiro, Ruiz-Picazo, Alejandro, Gonzalez-Alvarez, Marta, Hens, Bart, Garcia-Arieta, Alfredo, Amidon, Greg E, Amidon, Gordon L

“…The purpose of this study was to predict in vivo performance of three oral products of Etoricoxib ( as reference and two generic formulations in development)…”
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One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products by Prieto-Escolar, Mercedes, Torrado, Juan J, Álvarez, Covadonga, Ruiz-Picazo, Alejandro, Simón-Vázquez, Marta, Govantes, Carlos, Frias, Jesús, García-Arieta, Alfredo, Gonzalez-Alvarez, Isabel, Bermejo, Marival

“…Montelukast is a weak acid drug characterized by its low solubility in the range of pH 1.2 to 4.5, which may lead to dissolution-limited absorption. The aim of…”
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Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development by Miranda, Claudia, Ruiz-Picazo, Alejandro, Pomares, Paula, Gonzalez-Alvarez, Isabel, Bermejo, Marival, Gonzalez-Alvarez, Marta, Avdeef, Alex, Cabrera-Pérez, Miguel-Ángel

“…The main aim of this work is the biopharmaceutical characterization of a new hybrid benzodiazepine-dihydropyridine derivative, JM-20, derived with potent…”
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Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses by Bermejo, Marival, Kuminek, Gislaine, Al-Gousous, Jozef, Ruiz-Picazo, Alejandro, Tsume, Yasuhiro, Garcia-Arieta, Alfredo, González-Alvarez, Isabel, Hens, Bart, Amidon, Gregory E, Rodriguez-Hornedo, Nair, Amidon, Gordon L, Mudie, Deanna

“…The present work aimed to explain the differences in oral performance in fasted humans who were categorized into groups based on the three different drug…”
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pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis by González-Alvarez, Isabel, Vivancos, Verónica, Coll, Carmen, Sánchez-Dengra, Bárbara, Aznar, Elena, Ruiz-Picazo, Alejandro, Bermejo, Marival, Sancenón, Félix, Dea-Ayuela, María Auxiliadora, Gonzalez-Alvarez, Marta, Martínez-Máñez, Ramón

“…Giardiasis is a parasitism produced by the protozoa that lives as trophozoite in the small intestine (mainly in the duodenum) attached to the intestinal villus…”
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Effect of Common Excipients on Intestinal Drug Absorption in Wistar Rats by Ruiz-Picazo, Alejandro, Gonzalez-Alvarez, Marta, Gonzalez-Alvarez, Isabel, Bermejo, Marival

“…The aim of the present paper is to study the effect of common excipients on the permeability of atenolol (as drug absorbed mainly by passive diffusion) and…”
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Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients by Ruiz-Picazo, Alejandro, Colón-Useche, Sarin, Gonzalez-Alvarez, Marta, Gonzalez-Alvarez, Isabel, Bermejo, Marival, Langguth, Peter

“…[Display omitted] Dysphagia is a very common problem suffered by elderly patients. The use of thickeners during administration in these patients helps to…”
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In vitro prediction of in vivo absorption of ibuprofen from suspensions through rational choice of dissolution conditions by Hofmann, Michael, García, Mauricio A., Al-Gousous, Jozef, Ruiz-Picazo, Alejandro, Thieringer, Florian, Nguyen, Mai A., Månsson, Wiking, Galle, Peter R., Langguth, Peter

“…[Display omitted] Two ibuprofen suspension formulations were investigated for their dissolution in various bicarbonate, phosphate and acetate buffers…”
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Advancing the Harmonization of Biopredictive Methodologies through the Product Quality Research Institute (PQRI) Consortium: Biopredictive Dissolution of Dipyridamole Tablets by Tsume, Yasuhiro, Ashworth, Lee, Bermejo Sanz, Marival, Cicale, Vincent, Dressman, Jennifer, Fushimi, Masahiro, Gonzalez-Alvarez, Isabel, Haung, Pin-Syuan, Jankovsky, Corinne, Liu, Xiaohong, Lu, Xujin, Matsui, Kazuki, Patel, Sanjaykumar, Ruiz-Picazo, Alejandro, Sun, Changquan Calvin, Thakral, Naveen, Zöller, Laurin

“…Biorelevant dissolution and its concept have been widely accepted and further developed to meaningfully predict the bioperformance of oral drug products…”
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Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin by Caldeira, Tamires Guedes, Ruiz-Picazo, Alejandro, Lozoya-Agullo, Isabel, Saúde-Guimarães, Dênia Antunes, González-Álvarez, Marta, de Souza, Jacqueline, González-Álvarez, Isabel, Bermejo, Marival

“…[Display omitted] The purpose of this work was to describe the closed loop in situ perfusion method in rats and to compare the difficulties and advantages with…”
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Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products by Ruiz-Picazo, Alejandro, Colón-Useche, Sarin, Perez-Amorós, Blanca, González-Álvarez, Marta, Molina-Martínez, Irene, González-Álvarez, Isabel, García-Arieta, Alfredo, Bermejo, Marival

“…The purpose of this work is to explore the predictive ability of the biopharmaceutics classification system (BCS) biowaiver based on the dissolution methods…”
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