Search Results - "Ruiz, Maria Armila"

Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis) by Ibanez, Vinzon, Vaitkus, Kestis, Ruiz, Maria Armila, Lei, Zhengdeng, Maienschein-Cline, Mark, Arbieva, Zarema, Lavelle, Donald

“…Elevated levels of Fetal Hemoglobin interfere with polymerization of sickle hemoglobin thereby reducing anemia, lessening the severity of symptoms, and…”
Get full text

Soluble urokinase plasminogen activator receptor is associated with kidney disease and its progression in sickle cell anemia by Zahr, Rima S, Rashkin, Sara R, Ruiz, Maria Armila, Elsherif, Laila, Ren, Guohui, Salas, Guadalupe, Ataga, Kenneth I, Gordeuk, Victor R, Lebensburger, Jeffrey, Zhang, Xu, Saraf, Santosh L

Get full text

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis) by Rivers, Angela, Vaitkus, Kestis, Ibanez, Vinzon, Ruiz, Maria Armila, Jagadeeswaran, Ramasamy, Saunthararajah, Yogen, Cui, Shuaiying, Engel, James D, DeSimone, Joseph, Lavelle, Donald

“…Increased fetal hemoglobin levels lessen the severity of symptoms and increase the lifespan of patients with sickle cell disease. Hydroxyurea, the only drug…”
Get full text

Effect of AGM and fetal liver-derived stromal cell lines on globin expression in adult baboon (P. anubis) bone marrow-derived erythroid progenitors by Lavelle, Donald, Vaitkus, Kestutis, Ruiz, Maria Armila, Ibanez, Vinzon, Kouznetsova, Tatiana, Saunthararajah, Yogen, Mahmud, Nadim, DeSimone, Joseph

“…This study was performed to investigate the hypothesis that the erythroid micro-environment plays a role in regulation of globin gene expression during adult…”
Get full text

Effect of the LSD1 inhibitor RN-1 on [gamma]-globin and global gene expression during erythroid differentiation in baboons by Ibanez, Vinzon, Vaitkus, Kestis, Ruiz, Maria Armila, Lei, Zhengdeng, Maienschein-Cline, Mark, Arbieva, Zarema, Lavelle, Donald

“…Elevated levels of Fetal Hemoglobin interfere with polymerization of sickle hemoglobin thereby reducing anemia, lessening the severity of symptoms, and…”
Get full text

Fruit and Vegetable Intake in Adults with Sickle Cell Disease by Ally, Syeda Akila, Han, Jin, Molokie, Robert, Ruiz, Maria Armila, Gordeuk, Victor R., Lash, James, Saraf, Santosh L.

“…Introduction Patients with sickle cell disease (SCD) experience frequent disruptions to their daily lives from vaso-occlusive pain episodes and chronic organ…”
Get full text

Thrombomodulin Protects Against Cell-Free Hemoglobin Mediated Acute Kidney Injury in Sickle Cell Anemia by Ren, Guohui, Chen, Jiwang, Minshall, Richard, Castellon, Maricela, Ruiz, Maria Armila, Gordeuk, Victor R., Saraf, Santosh L.

“…Thrombomodulin (TM) is a transmembrane protein that plays a pivotal role in maintaining microvascular health. Functions of TM include 1) binding thrombin and…”
Get full text

A Pilot Study for the Kidney Effects of Voxelotor in Sickle Cell Anemia by Saraf, Santosh L., Krauz, Lani, Molokie, Robert, Njoku, Franklin, Ruiz, Maria Armila, Salas, Guadalupe, Aziz-Bradley, Alana, Han, Jin, Gordeuk, Victor R.

“…The kidneys are among the most commonly affected organ systems in sickle cell anemia (SCA) and an estimated 15% of deaths in patients with SCA are attributed…”
Get full text

Improved Hemolytic Anemia with GBT1118 Is Reno-Protective in Transgenic Sickle Mice by Ren, Guohui, Ruiz, Maria Armila, Setty, Suman L, Minshall, Richard, Lash, James P., Gordeuk, Victor R., Saraf, Santosh L.

“…Intravascular hemolysis releases cell-free hemoglobin and heme into the circulation. When haptoglobin and hemopexin are depleted, as observed in sickle cell…”
Get full text

Thrombomodulin and Endothelial Dysfunction in Sickle Cell Anemia by Ruiz, Maria Armila, Shah, Binal N., Han, Jin, Raslan, Rasha, Gordeuk, Victor R, Saraf, Santosh L.

“…Thrombomodulin (THBD) is a transmembrane protein that regulates endothelial function by 1) binding thrombin and inhibiting its interaction with fibrinogen, 2)…”
Get full text

Prevalence of kidney health genetic variants in adults with sickle cell nephropathy by Ruiz, Maria Armila, Zhang, Xu, Mansilla, M. Adela, Zahr, Rima S., Thomas, Christie P., Smith, Richard J., Gordeuk, Victor R., Saraf, Santosh L.

“…Summary The pathophysiology and genetic risk for sickle cell disease (SCD)‐related chronic kidney disease (CKD) are not well understood. In 70 adults with…”
Get full text

Clinical and Biomarker Predictors for Avascular Necrosis in Sickle Cell Disease by Rabaza, Michael, Ruiz, Maria Armila, Posch, Liana, Hussain, Faiz Ahmed, Njoku, Franklin, Molokie, Robert E., Han, Jin, Gordeuk, Victor R., Xie, Karen, Saraf, Santosh L.

“…Introduction Sickle cell disease (SCD) affects 1 in 365 African Americans and approximately 25 million people world-wide. A common skeletal system complication…”
Get full text

Haptoglobin 1-1 Isoform Predicts Higher Serum Haptoglobin Concentration and Lower Multiorgan Failure Risk in Sickle Cell Disease by Ruiz, Maria Armila, Shuey, David, Han, Jin, Shah, Binal N., Minshall, Richard, Lash, James P., Gordeuk, Victor R., Saraf, Santosh L.

“…▪ Haptoglobin (HP) is the major scavenger of cell-free hemoglobin in circulation. When haptoglobin is depleted, cell-free hemoglobin can lead to organ damage…”
Get full text

Defining and Predicting Rapid Egfr Decline in Sickle Cell Disease by Saraf, Santosh L., Han, Jin, Ruiz, Maria Armila, Srisuwananukorn, Andrew, Shuey, David, Hussain, Faiz Ahmed, Njoku, Franklin, Molokie, Robert E., Gordeuk, Victor R.

“…Chronic kidney disease is observed in up to 50% of adults with sickle cell disease (SCD) and is a consistent predictor for increased morbidity and early…”
Get full text

RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model by Rivers, Angela, Vaitkus, Kestis, Ruiz, Maria Armila, Ibanez, Vinzon, Jagadeeswaran, Ramasamy, Kouznetsova, Tatiana, DeSimone, Joseph, Lavelle, Donald

“…Increased levels of fetal hemoglobin are associated with decreased symptoms and increased lifespan in patients with sickle cell disease (SCD). Hydroxyurea, the…”
Get full text

Thrombomodulin and Multi-Organ Failure in Sickle Cell Anemia by Ruiz, Maria Armila, Shah, Binal N., Ren, Guohui, Shuey, David, Minshall, Richard D., Gordeuk, Victor R., Saraf, Santosh L.

Get full text

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression by Vaitkus, Kestis, Ibanez, Vinzon, Ruiz, Maria Armila, Jagadeeswaran, Ramasamy, Saunthararajah, Yogenthiran, Engel, James Douglas, DeSimone, Joseph, Rivers, Angela, Lavelle, Donald

“…The HbF to HbA developmental globin switch is recapitulated during adult erythroid differentiation and involves the acquisition of repressive epigenetic marks…”
Get full text

Thrombomodulin and multiorgan failure in sickle cell anemia by Ruiz, Maria Armila, Shah, Binal N., Ren, Guohui, Shuey, David, Minshall, Richard D., Gordeuk, Victor R., Saraf, Santosh L.

Get full text

Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons by Rivers, Angela, Vaitkus, Kestis, Jagadeeswaran, Ramasamy, Ruiz, Maria Armila, Ibanez, Vinzon, Ciceri, Filippo, Cavalcanti, Fernando, Molokie, Robert E., Saunthararajah, Yogen, Engel, James Douglas, DeSimone, Joseph, Lavelle, Donald

“…Increased levels of fetal hemoglobin (HbF) lessen the severity of symptoms and increase the life span of patients with sickle cell disease (SCD). More…”
Get full text

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons by Rivers, Angela, Vaitkus, Kestis, Jagadeeswaran, Ramasamy, Ibanez, Vinzon, Ruiz, Maria Armila, Ciceri, Filippo, Cavalcanti, Fernando, Molokie, Robert E., Lavelle, Donald

“…Increased levels of fetal hemoglobin (HbF) lessen the severity of symptoms and increase the life span of patients with sickle cell disease (SCD). New and more…”
Get full text