Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002

Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001–2002

Summary Objectives Recognizing the uniqueness of secondary dengue virus (DENV)-1/3 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) cases at an interval of 24 years, we sought to estimate DENV infections as well as the ratios between mild disease and DHF/DSS by DENV infection sequence in Pla...

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Published in:International journal of infectious diseases Vol. 16; no. 3; pp. e198 - e203
Main Authors: Guzman, Maria G, Alvarez, Angel, Vazquez, Susana, Alvarez, Mayling, Rosario, Delfina, Pelaez, Otto, Cruz, Guillermo, Rodriguez, Rosmari, Pavon, Alequis, Gonzalez, Annia, Morier, Luis, Ruiz, Dydie, Kouri, Gustavo, Halstead, Scott B
Format: Journal Article
Language:English
Published: Canada Elsevier Ltd 01-03-2012
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Neutralizing - blood
Child
Child, Preschool
Coinfection - epidemiology
Coinfection - virology
Cuba
Cuba - epidemiology
Dengue
Dengue hemorrhagic fever
Dengue Virus - pathogenicity
Dengue virus type 3
Disease Outbreaks
Epidemiologic Studies
Epidemiology
Female
Humans
Infectious Disease
Male
Middle Aged
Pathogenesis
Pulmonary/Respiratory
Retrospective Studies
Serotyping
Severe Dengue - epidemiology
Severe Dengue - virology
Young Adult
Cuba
Cuba
Dengue virus type 3
Dengue hemorrhagic fever
Pathogenesis
Epidemiology
Dengue
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Summary:Summary Objectives Recognizing the uniqueness of secondary dengue virus (DENV)-1/3 dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) cases at an interval of 24 years, we sought to estimate DENV infections as well as the ratios between mild disease and DHF/DSS by DENV infection sequence in Playa District (Havana, Cuba) during the 2001–2002 outbreak of dengue virus type 3 (DENV-3). Methods A retrospective seroepidemiological study was conducted in 2003 in Playa District. Blood samples were collected from a 1% random sample of residents and were studied for the prevalence of dengue neutralizing antibodies. Results DENV-3 was found to have infected 7.2% (95% confidence interval (95% CI) 6.0–8.4%) of susceptible individuals (the entire cohort), the majority of whom experienced silent infections. Virtually every individual who had a secondary infection in the sequence DENV-1 then DENV-3 became ill, with a ratio of severe to mild cases of 1:35 (95% CI 1:67–1:23). Secondary infections in the sequence DENV-2/3 were less pathogenic than DENV-1/3. Mild disease accompanying secondary DENV2/3 occurred at a ratio of 1:4.49 infections (95% CI 1:5.77–1:3.42) secondary infections. Conclusions The results obtained highlight the role of the infecting serotype and also the sequence of the viral infection in the clinical outcome of a dengue infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2011.09.026