Search Results - "Ruiz, Ariel"

Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer by Nowak-Sliwinska, Patrycja, Scapozza, Leonardo, Altaba, Ariel Ruiz i

“…The strategy of using existing drugs originally developed for one disease to treat other indications has found success across medical fields. Such drug…”
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The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases by Mishra, Sonakshi, Bernal, Carolina, Silvano, Marianna, Anand, Santosh, Ruiz i Altaba, Ariel

“…How cells in primary tumors initially become pro-metastatic is not understood. A previous genome-wide RNAi screen uncovered colon cancer metastatic suppressor…”
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On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm by Conod, Arwen, Silvano, Marianna, Ruiz i Altaba, Ariel

“…How metastatic cells arise is unclear. Here, we search for the induction of recently characterized pro-metastatic states as a surrogate for the origin of…”
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The Gli code: an information nexus regulating cell fate, stemness and cancer by Ruiz i Altaba, Ariel, Mas, Christophe, Stecca, Barbara

“…The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog…”
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Genomic diversity and population structure of teosinte (Zea spp.) and its conservation implications by Rivera-Rodríguez, Diana María, Mastretta-Yanes, Alicia, Wegier, Ana, De la Cruz Larios, Lino, Santacruz-Ruvalcaba, Fernando, Ruiz Corral, José Ariel, Hernández, Benjamín, Sánchez González, José de Jesús

“…The wild species of the genus Zea commonly named teosintes, comprise nine different taxa, distributed from northern Mexico to Costa Rica. Although this genus…”
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Ecogeography of teosinte by Sánchez González, José de Jesús, Ruiz Corral, José Ariel, García, Guillermo Medina, Ojeda, Gabriela Ramírez, Larios, Lino De la Cruz, Holland, James Brendan, Medrano, Roberto Miranda, García Romero, Giovanni Emmanuel

“…Adaptation of crops to climate change has motivated an increasing interest in the potential value of novel traits from wild species; maize wild relatives, the…”
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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways by Stecca, Barbara, Mas, Christophe, Clement, Virginie, Zbinden, Marie, Correa, Rafael, Piguet, Vincent, Beermann, Friedrich, Ruiz i Altaba, Ariel

“…Melanoma is one of the most aggressive cancers, and its incidence is increasing. These tumors derive from the melanocyte lineage and remain incurable after…”
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The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT‐TCF pathway responses in human cancer by Melotti, Alice, Mas, Christophe, Kuciak, Monika, Lorente‐Trigos, Aiala, Borges, Isabel, Ruiz i Altaba, Ariel

“…Constitutive activation of canonical WNT‐TCF signaling is implicated in multiple diseases, including intestine and lung cancers, but there are no WNT‐TCF…”
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Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling by Seth, Chandan, Ruiz i Altaba, Ariel

“…Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling…”
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Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers by Kaushik, Ajeet, Jayant, Rahul D., Nikkhah-Moshaie, Roozbeh, Bhardwaj, Vinay, Roy, Upal, Huang, Zaohua, Ruiz, Ariel, Yndart, Adriana, Atluri, Venkata, El-Hage, Nazira, Khalili, Kamel, Nair, Madhavan

“…Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to…”
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A novel genome‐wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT‐TCF pathway modulators TMED3 and SOX12 by Duquet, Arnaud, Melotti, Alice, Mishra, Sonakshi, Malerba, Monica, Seth, Chandan, Conod, Arwen, Ruiz i Altaba, Ariel

“…The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays…”
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Therapeutic Inhibition of Hedgehog-GLI Signaling in Cancer: Epithelial, Stromal, or Stem Cell Targets? by Ruiz i Altaba, Ariel

“…Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proliferation that has been shown also to regulate cancer stem…”
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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex by Palma, Veronica, Ruiz i Altaba, Ariel

“…Stem cells are crucial for normal development and homeostasis, and their misbehavior may be related to the origin of cancer. Progress in these areas has been…”
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Incorporating evolutionary and threat processes into crop wild relatives conservation by Tobón-Niedfeldt, Wolke, Mastretta-Yanes, Alicia, Urquiza-Haas, Tania, Goettsch, Bárbara, Cuervo-Robayo, Angela P., Urquiza-Haas, Esmeralda, Orjuela-R, M. Andrea, Acevedo Gasman, Francisca, Oliveros-Galindo, Oswaldo, Burgeff, Caroline, Rivera-Rodríguez, Diana M., Sánchez González, José de Jesús, Alarcón-Guerrero, Jesús, Aguilar-Meléndez, Araceli, Aragón Cuevas, Flavio, Alavez, Valeria, Alejandre-Iturbide, Gabriel, Avendaño-Arrazate, Carlos-H., Azurdia Pérez, César, Delgado-Salinas, Alfonso, Galán, Pablo, González-Ledesma, Manuel, Hernández-Ruíz, Jesús, Lorea-Hernández, Francisco G., Lira Saade, Rafael, Rodríguez, Aarón, Rodríguez Delcid, Dagoberto, Ruiz-Corral, José Ariel, Santos Pérez, Juan José, Vargas-Ponce, Ofelia, Vega, Melania, Wegier, Ana, Quintana-Camargo, Martín, Sarukhán, José, Koleff, Patricia

“…Crop wild relatives (CWR) intra- and interspecific diversity is essential for crop breeding and food security. However, intraspecific genetic diversity, which…”
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HEDGEHOG-GLI1 Signaling Regulates Human Glioma Growth, Cancer Stem Cell Self-Renewal, and Tumorigenicity by Clement, Virginie, Sanchez, Pilar, de Tribolet, Nicolas, Radovanovic, Ivan, Ruiz i Altaba, Ariel

“…Cancer stem cells are rare tumor cells characterized by their ability to self-renew and to induce tumorigenesis. They are present in gliomas and may be…”
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Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells by Seth, Chandan, Mas, Christophe, Conod, Arwen, Mueller, Jens, Siems, Karsten, Kuciak, Monika, Borges, Isabel, Ruiz I Altaba, Ariel

“…The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the…”
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Brain-derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both species by Garcés, María F., Sanchez, Elizabeth, Torres-Sierra, Alejandra L., Ruíz-Parra, Ariel I., Angel-Müller, Edith, Alzate, Juan P., Sánchez, Ángel Y., Gomez, Martín A., Romero, Ximena C., Castañeda, Zoila E., Sanchez-Rebordelo, Estrella, Diéguez, Carlos, Nogueiras, Rubén, Caminos, Jorge E.

“…Summary Objective Pregnancy is characterized by several metabolic changes that promote fat gain and later onset of insulin resistance. As Brain‐derived…”
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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain by Palma, Verónica, Lim, Daniel A, Dahmane, Nadia, Sánchez, Pilar, Brionne, Thomas C, Herzberg, Claudia D, Gitton, Yorick, Carleton, Alan, Alvarez-Buylla, Arturo, Ruiz i Altaba, Ariel

“…Sonic hedgehog (Shh) signaling controls many aspects of ontogeny, orchestrating congruent growth and patterning. During brain development, Shh regulates early…”
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Phenotypic identification of near isogenic maize teosinte lines (Zea spp.) involved for resistance to gray leaf spot by Guerrero‐Corona, Abraham, Santacruz Ruvalcaba, Fernando, Alberto Sánchez Nuño, José, Moya Raygoza, Gustavo, Ariel Ruiz Corral, José, De la Cruz Larios, Lino

“…Wild germplasm of Zea is a source of variation that could be used in plant breeding to improve maize resistance to diseases such as gray leaf spot (GLS). The…”
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Mapping Homogeneous Response Areas for Forest Fuel Management Using Geospatial Data, K-Means, and Random Forest Classification by Álvaro Agustín Chávez-Durán, Miguel Olvera-Vargas, Blanca Figueroa-Rangel, Mariano García, Inmaculada Aguado, José Ariel Ruiz-Corral

“…Accurate description of forest fuels is necessary for developing appropriate fire management strategies aimed at reducing fire risk. Although field surveys…”
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