Search Results - "Ruiters, Marcel H. J"

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner by Cano-Rodriguez, David, Gjaltema, Rutger A F., Jilderda, Laura J, Jellema, Pytrick, Dokter-Fokkens, Jelleke, Ruiters, Marcel H J., Rots, Marianne G

“…Histone modifications reflect gene activity, but the relationship between cause and consequence of transcriptional control is heavily debated. Recent…”
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EpCAM in carcinogenesis: the good, the bad or the ugly by van der Gun, Bernardina T.F., Melchers, Lieuwe J., Ruiters, Marcel H.J., de Leij, Lou F.M.H., McLaughlin, Pamela M.J., Rots, Marianne G.

“…The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that is highly expressed on most carcinomas and therefore of potential use as a…”
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Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System by Visweswaran, Ganesh Ram R, Gholizadeh, Shima, Ruiters, Marcel H J, Molema, Grietje, Kok, Robbert J, Kamps, Jan A A M

“…Together with mesangial cells, glomerular endothelial cells and the basement membrane, podocytes constitute the glomerular filtration barrier (GFB) of the…”
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Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia by Li, Ranran, Kowalski, Piotr S, Morselt, Henriëtte W M, Schepel, Ilona, Jongman, Rianne M, Aslan, Adnan, Ruiters, Marcel H J, Zijlstra, Jan G, Molema, Grietje, van Meurs, Matijs, Kamps, Jan A A M

“…Microvascular endothelial cells play a pivotal role in the pathogenesis of sepsis-induced inflammatory responses and multiple organ failure. Therefore, they…”
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Cationic lipid-formulated DNA vaccine against hepatitis B virus: immunogenicity of MIDGE-Th1 vectors encoding small and large surface antigen in comparison to a licensed protein vaccine by Endmann, Anne, Klünder, Katharina, Kapp, Kerstin, Riede, Oliver, Oswald, Detlef, Talman, Eduard G, Schroff, Matthias, Kleuss, Christiane, Ruiters, Marcel H J, Juhls, Christiane

“…Currently marketed vaccines against hepatitis B virus (HBV) based on the small (S) hepatitis B surface antigen (HBsAg) fail to induce a protective immune…”
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Experimental mitochondria-targeted DNA methylation identifies GpC methylation, not CpG methylation, as potential regulator of mitochondrial gene expression by van der Wijst, Monique G. P., van Tilburg, Amanda Y., Ruiters, Marcel H. J., Rots, Marianne G.

“…Like the nucleus, mitochondria contain their own DNA and recent reports provide accumulating evidence that also the mitochondrial DNA (mtDNA) is subjective to…”
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Combination of MIDGE-Th1 DNA vaccines with the cationic lipid SAINT-18: Studies on formulation, biodistribution and vector clearance by Endmann, Anne, Oswald, Detlef, Riede, Oliver, Talman, Eduard G, Vos, Roelien E, Schroff, Matthias, Kleuss, Christiane, Ruiters, Marcel H.J, Juhls, Christiane

“…Highlights • MIDGE-Th1/SAINT-18 lipoplexes were characterized in vitro and in vivo. • Transfection efficiency of lipoplexes increased with SAINT-18 amount in…”
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Establishment of protein delivery systems targeting podocytes by Chiang, Wen Chih, Geel, Tessa M, Altintas, Mehmet M, Sever, Sanja, Ruiters, Marcel H J, Reiser, Jochen

“…Podocytes are uniquely structured cells that are critical to the kidney filtration barrier. Their anatomic location on the outer side of the glomerular…”
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Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro — A quantitative study by Ásgeirsdóttir, Sigridur A., Talman, Eduard G., de Graaf, Inge A., Kamps, Jan A.A.M., Satchell, Simon C., Mathieson, Peter W., Ruiters, Marcel H.J., Molema, Grietje

“…Applications of small-interfering RNA (siRNA) call for specific and efficient delivery of siRNA into particular cell types. We developed a novel, non-viral…”
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Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells by Adrian, Joanna E., Morselt, Henriëtte W.M., Süss, Regine, Barnert, Sabine, Kok, Jan Willem, Ásgeirsdóttir, Sigridur A., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.

“…In non-phagocytic cells such as endothelial cells, processing of liposomes and subsequent release of drug content is often inefficient due to the absence of…”
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The Mitochondrial Epigenome: An Unexplored Avenue to Explain Unexplained Myopathies? by Mposhi, Archibold, Liang, Lin, Mennega, Kevin P, Yildiz, Dilemin, Kampert, Crista, Hof, Ingrid H, Jellema, Pytrick G, de Koning, Tom J, Faber, Klaas Nico, Ruiters, Marcel H J, Niezen-Koning, Klary E, Rots, Marianne G

“…Mutations in either mitochondrial DNA (mtDNA) or nuclear genes that encode mitochondrial proteins may lead to dysfunctional mitochondria, giving rise to…”
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Anti-VCAM‑1 and Anti-E-selectin SAINT-O-Somes for Selective Delivery of siRNA into Inflammation-Activated Primary Endothelial Cells by Kowalski, Piotr S, Lintermans, Lucas L, Morselt, Henriëtte W. M, Leus, Niek G. J, Ruiters, Marcel H. J, Molema, Grietje, Kamps, Jan A. A. M

“…Activated endothelial cells play a pivotal role in the pathology of inflammatory diseases and present a rational target for therapeutic intervention by…”
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Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2 by VAN DER GUN, Bernardina T. F, MONAMI, Amélie, MCLAUGHLIN, Pamela M. J, LAARMANN, Sven, RASKO, Tamas, SLASKA-KISS, Krystyna, WEINHOLD, Elmar, WASSERKORT, Reinhold, DE LEIJ, Lou F. M. H, RUITERS, Marcel H. J, KISS, Antal

“…Cationic liposomal compounds are widely used to introduce DNA and siRNA into viable cells, but none of these compounds are also capable of introducing…”
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Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo by Kowalski, Piotr S., Zwiers, Peter J., Morselt, Henriëtte W.M., Kuldo, Joanna M., Leus, Niek G.J., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.

“…The pivotal role of endothelial cells in the pathology of inflammatory diseases raised interest in the development of short interfering RNA (siRNA) delivery…”
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Efficient nontoxic delivery of PD-L1 and PD-L2 siRNA into dendritic cell vaccines using the cationic lipid SAINT-18 by Roeven, Mieke W H, Hobo, Willemijn, van der Voort, Robbert, Fredrix, Hanny, Norde, Wieger J, Teijgeler, Kasper, Ruiters, Marcel H J, Schaap, Nicolaas, Dolstra, Harry

“…Dendritic cell (DC)-based vaccination is an appealing strategy to boost graft-versus-tumor immunity after allogeneic stem cell transplantation (allo-SCT), and…”
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VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression by Leus, Niek G.J., Morselt, Henriëtte W.M., Zwiers, Peter J., Kowalski, Piotr S., Ruiters, Marcel H.J., Molema, Grietje, Kamps, Jan A.A.M.

“…[Display omitted] In recent years much research in RNA nanotechnology has been directed to develop an efficient and clinically suitable delivery system for…”
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Targeted siRNA delivery to diseased microvascular endothelial cells—Cellular and molecular concepts by Kowalski, Piotr S., Leus, Niek G. J., Scherphof, Gerrit L., Ruiters, Marcel H. J., Kamps, Jan A. A. M., Molema, Grietje

“…Increased insight in the role of endothelial cells in the pathophysiology of cancer, inflammatory and cardiovascular diseases, has drawn great interest in…”
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Targeted DNA Methylation by a DNA Methyltransferase Coupled to a Triple Helix Forming Oligonucleotide To Down-Regulate the Epithelial Cell Adhesion Molecule by van der Gun, Bernardina T. F, Maluszynska-Hoffman, Maria, Kiss, Antal, Arendzen, Alice J, Ruiters, Marcel H. J, McLaughlin, Pamela M. J, Weinhold, Elmar, Rots, Marianne G

“…The epithelial cell adhesion molecule (EpCAM) is a membrane glycoprotein that has been identified as a marker of cancer-initiating cells. EpCAM is highly…”
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Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter by Chen, Hui, Kazemier, Hinke G, de Groote, Marloes L, Ruiters, Marcel H J, Xu, Guo-Liang, Rots, Marianne G

“…Increasing evidence indicates that active DNA demethylation is involved in several processes in mammals, resulting in developmental stage-specificity and cell…”
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Persistent downregulation of the pancarcinoma‐associated epithelial cell adhesion molecule via active intranuclear methylation by van der Gun, Bernardina T.F., Wasserkort, Reinhold, Monami, Amélie, Jeltsch, Albert, Raskó, Tamás, Ślaska‐Kiss, Krystyna, Cortese, Rene, Rots, Marianne G., de Leij, Lou F.M.H., Ruiters, Marcel H.J., Kiss, Antal, Weinhold, Elmar, McLaughlin, Pamela M.J.

“…The epithelial cell adhesion molecule (EpCAM) is expressed at high levels on the surface of most carcinoma cells. SiRNA silencing of EpCAM expression leads to…”
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