Search Results - "Ruitenberg, M J"

Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection by Hellström, M, Ruitenberg, M J, Pollett, M A, Ehlert, E M E, Twisk, J, Verhaagen, J, Harvey, A R

“…Recombinant adeno-associated virus (rAAV) vectors are increasingly being used as tools for gene therapy, and clinical trials have begun in patients with…”
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Feasibility study of real-time three-/four-dimensional ultrasound for epidural catheter insertion by Belavy, D., Ruitenberg, M.J., Brijball, R.B.

“…Real-time two-dimensional (2D) ultrasound can be used to facilitate neuraxial anaesthesia. Four-dimensional (4D) ultrasound allows the use of multiple imaging…”
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Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord by EATON, M. J, BLITS, B, RUITENBERG, M. J, VERHAAGEN, J, OUDEGA, M

“…Changing the levels of neurotrophins in the spinal cord micro-environment after nervous system injury has been proposed to recover normal function, such that…”
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Injury-Induced Class 3 Semaphorin Expression in the Rat Spinal Cord by De Winter, F., Oudega, M., Lankhorst, A.J., Hamers, F.P., Blits, B., Ruitenberg, M.J., Pasterkamp, R.J., Gispen, W.H., Verhaagen, J.

“…In this study we evaluate the expression of all members of the class 3 semaphorins and their receptor components following complete transection and contusion…”
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Expression of the Gene Encoding the Chemorepellent Semaphorin III Is Induced in the Fibroblast Component of Neural Scar Tissue Formed Following Injuries of Adult But Not Neonatal CNS by Pasterkamp, R.J., Giger, R.J., Ruitenberg, M-J., Holtmaat, A.J.G.D., De Wit, J., De Winter, F., Verhaagen, J.

“…This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema III) following lesions to the rat CNS. Scar tissue, formed after…”
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NT-3 expression from engineered olfactory ensheathing glia promotes spinal sparing and regeneration by Ruitenberg, Marc J., Levison, Dane B., Lee, Seok Voon, Verhaagen, Joost, Harvey, Alan R., Plant, Giles W.

“…Adenoviral (AdV) vectors encoding neurotrophin-3 (AdV-NT-3) or the bacterial marker enzyme β-galactosidase (LacZ gene) were used to transduce olfactory…”
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Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord by RUITENBERG, M. J, PLANT, G. W, CHRISTENSEN, C. L, BLITS, B, NICLOU, S. P, HARVEY, A. R, BOER, G. J, VERHAAGEN, J

“…Implantation of olfactory ensheathing glia (OEG) is a promising strategy to augment long-distance regeneration in the injured spinal cord. In this study,…”
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Prognostic value of micrometastases in sentinel lymph nodes of patients with breast carcinoma: a cohort study by Gobardhan, P.D., Elias, S.G., Madsen, E.V.E., Bongers, V., Ruitenberg, H.J.M., Perre, C.I., van Dalen, T.

“…Background: The prognostic meaning and thus indication for adjuvant therapy of lymphogenic micrometastases in breast cancer patients is still under debate…”
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Semaphorins and their receptors in olfactory axon guidance by Pasterkamp, R J, Ruitenberg, M J, Verhaagen, J

“…The mammalian olfactory system is capable of discriminating among a large variety of odor molecules and is therefore essential for the identification of food,…”
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Viral vector-mediated gene expression in olfactory ensheathing glia implants in the lesioned rat spinal cord by Ruitenberg, MJ, Plant, G W, Christensen, CL, Blits, B, Niclou, S P, Harvey, A R, Boer, G J, Verhaagen, J

“…Implantation of olfactory ensheathing glia (OEG) is a promising strategy to augment long-distance regeneration in the injured spinal cord. In this study,…”
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Novel Characterization of Monocyte-Derived Cell Populations in the Meninges and Choroid Plexus and Their Rates of Replenishment in Bone Marrow Chimeric Mice by Chinnery, Holly R, Ruitenberg, Marc J, McMenamin, Paul G

“…The mouse dura mater, pia mater, and choroid plexus contain resident macrophages and dendritic cells (DCs). These cells participate in immune surveillance,…”
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Cellular tropism and transduction properties of seven adeno-associated viral vector serotypes in adult retina after intravitreal injection: Special Issue on Gene Therapy for Chronic Pain by HELLSTRÖM, M, RUITENBERG, M. J, POLLETT, M. A, EHLERT, E. M. E, TWISK, J, VERHAAGEN, J, HARVEY, A. R

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Ex Vivo Adenoviral Vector-Mediated Neurotrophin Gene Transfer to Olfactory Ensheathing Glia: Effects on Rubrospinal Tract Regeneration, Lesion Size, and Functional Recovery after Implantation in the Injured Rat Spinal Cord by Ruitenberg, Marc J, Plant, Giles W, Hamers, Frank P. T, Wortel, Joke, Blits, Bas, Dijkhuizen, Paul A, Gispen, Willem Hendrik, Boer, Gerard J, Verhaagen, Joost

“…The present study uniquely combines olfactory ensheathing glia (OEG) implantation with ex vivo adenoviral (AdV) vector-based neurotrophin gene therapy in an…”
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Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor by Blits, Bas, Carlstedt, Thomas P., Ruitenberg, Marc Jan, de Winter, Fred, Hermens, Wim T.J.M.C., Dijkhuizen, Paul A., Claasens, Jill W.C., Eggers, Ruben, van der Sluis, Ronald, Tenenbaum, Liliane, Boer, Gerard J., Verhaagen, Joost

“…Following avulsion of a spinal ventral root, motoneurons that project through the avulsed root are axotomized. Avulsion between, for example, L2 and L6 leads…”
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Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord by Hendriks, William T, Ruitenberg, Marc J, Blits, Bas, Boer, Gerard J, Verhaagen, Joost

“…Injuries to the adult mammalian spinal cord often lead to severe damage to both ascending (sensory) pathways and descending (motor) nerve pathways without the…”
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Olfactory ensheathing cells: characteristics, genetic engineering, and therapeutic potential by Ruitenberg, Marc J, Vukovic, Jana, Sarich, Julijana, Busfield, Samantha J, Plant, Giles W

“…Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in…”
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CX3CL1/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium by Ruitenberg, Marc J, Vukovic, Jana, Blomster, Linda, Hall, Jarrad M, Jung, Steffen, Filgueira, Luis, McMenamin, Paul G, Plant, Giles W

“…Abstract The olfactory epithelium (OE) is a site of massive adult neurogenesis where olfactory sensory neurons (OSNs) are continuously turned over. Tissue…”
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Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat by Hendriks, William T J, Eggers, Ruben, Ruitenberg, Marc J, Blits, Bas, Hamers, Frank P T, Verhaagen, Joost, Boer, Gerard J

“…The purpose of this study was to compare spontaneous functional recovery after different spinal motor tract lesions in the rat spinal cord using three methods…”
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Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury by Ruitenberg, Marc J, Blits, Bas, Dijkhuizen, Paul A, te Beek, Erik T, Bakker, Arne, van Heerikhuize, Joop J, Pool, Chris W, Hermens, Wim T.J, Boer, Gerard J, Verhaagen, Joost

“…Rubrospinal neurons (RSNs) undergo marked atrophy after cervical axotomy. This progressive atrophy may impair the regenerative capacity of RSNs in response to…”
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Adeno-associated viral vectors as agents for gene delivery: application in disorders and trauma of the central nervous system by Ruitenberg, Marc J, Eggers, Ruben, Boer, Gerard J, Verhaagen, Joost

“…The use of viral vectors as agents for gene delivery provides a direct approach to manipulate gene expression in the mammalian central nervous system (CNS)…”
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